Cardiac involvement in children with acquired immune defifiency

Issenberg, Henry J.; Charytan, Morris; Rubinstein, Arye

doi:10.1016/0002-8703(85)90137-1

Cited by 22 publications

(7 citation statements)

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“…Reported incidences range from 9% to 65%, depending on the manner of ascertainment. [11][12][13][14][15][16][17][18] Our 37% prevalence of LV dysfunction in HIV-infected children accords with previous reports. Al-Atta et al reported that encephalopathy, wasting, a decreased CD4 count and a history of a serious cardiac event were all predictors of cardiac complications associated with HIV infection in children.…”

Section: Managementsupporting

confidence: 88%

“…It was more common in HIVinfected children in Zimbabwe (60%) 5 and a previous Thai study (42%) 6 than in the USA (16-26%). 2,13,14,16,22 The advanced stage of HIV disease is commonly associated with the development of pericardial effusion. 23 HAART, which is now regular therapy in industrialised countries, might decrease the prevalence of pericardial effusion in HIV-infected children.…”

Section: Managementmentioning

confidence: 99%

“…[24][25][26][27] Pulmonary hypertension accounted for 8-17% of HIV-infected children in the USA before 1991 (and HAART). [13][14][15] However, it is now less prevalent and there was no single case of pulmonary hypertension in the prospective P 2 C 2 multi-centre study. 11 The prevalence of pulmonary hypertension was relatively high in this study compared with cases in Zimbabwe 5 and the previous study from Thailand.…”

Section: Managementmentioning

confidence: 99%

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Cardiac manifestations in HIV-infected Thai children

Pongprot

Sittiwangkul

Silvilairat

et al. 2004

Annals of Tropical Paediatrics

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Cardiac complications contribute significantly to morbidity and mortality in HIV-infected children. There have been few reports of cardiac manifestations in HIV-infected children in developing countries. The aims of this study were to evaluate the clinical manifestations and echocardiographic findings in Thai children with HIV infection and determine the clinical predictors of left ventricular dysfunction and pulmonary hypertension. We retrospectively reviewed the medical records of 27 infants infected with HIV perinatally who presented with cardiovascular problems at a tertiary care hospital between 1995 and 2000. The mean age at initial cardiac evaluation was 36 months (range 8-65). Signs and symptoms included dyspnoea in all cases, oedema in 12 (44%), finger clubbing in 11 (41%), cyanosis in 6 (22%) and S(3) gallop in 8 (30%). Echocardiographic abnormalities included pericardial effusion in 12 (44 %), right ventricular dilatation in 12 (44%), pulmonary hypertension in 11 (41%), diminished left ventricular fractional shortening in 10 (37%), left ventricular dilatation in 9 (33%) and combined ventricular dilatation in 2 (7%). Left ventricular dysfunction did not correlate with HIV CDC classification, age, nutritional status or clinical signs and symptoms.

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Section: Managementsupporting

confidence: 88%

Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

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Cardiac manifestations in HIV-infected Thai children

Pongprot

Sittiwangkul

Silvilairat

et al. 2004

Annals of Tropical Paediatrics

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“…This is consistent with other similar studies that have reported a prevalence ranging between 18%-78%. [9][10][11][12][13][14][15][16][17][18][19] Specifically, LV dysfunction of 37% was reported from a Thai study in 2004. 8 The African study reported echocardiographic abnormalities in 51% abnormalities of the study population.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Manifestations in HIV Infected Children. Are they under Diagnosed?

Badal¹,

Gupta²,

Kumar³

et al. 2015

HIV/AIDS Res Treat Open J

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Background: The aim of this study was to evaluate cardiac manifestations in HIV-infected children in India. Methods & Results: This was a cross sectional study in HIV positive children up to 18 years of age, at a pediatric HIV clinic of a tertiary care teaching hospital in Maharashtra, India. All children were thoroughly evaluated by detailed history, clinical examination and underwent chest radiograph, Electrocardiograph (ECG) and Echocardiography (Echo). Of the 119 children who completed the study, the male to female ratio was 1.16:1 and the mean age was 8.9 years (range 2-17 years). Cardiovascular abnormalities were detected in 74 (62%) children on echo and / or ECG. Echocardiography alone was abnormal in 44 (36.9%) children and ECG alone was abnormal in 56 (47%) children. However, only 11(9%) children were found to be symptomatic with cardiovascular symptoms. The prevalence of Congenital Heart Disease (CHD) was 4%. The most common ECG abnormality observed in the study was sinus tachycardia in 35 (29%) followed by ST-T changes in 20 (16.8%).The most common echocardiographic abnormality encountered was LV systolic dysfunction seen in 31 (26%) cases, followed by Low LV ejection fraction in 24 (20%) cases. Children with abnormal echo and ECG were in higher WHO clinical and immunological stages (III & IV), however the association between the two was not found to be statistically significant. Conclusions: This study establishes that subclinical cardiac manifestations are prevalent in HIV infected children. More research should be done on the clinical significance of these findings and the need for long-term follow up.

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“…Several studies have reported cardiac involvement in AIDS primarily by autopsy and recently in prospective echocardiographic evaluation [2][3][4][5][6][7][8][9][10][11]. Cardiac involvement has been shown to occur in more than half the population of HIV-infected patients [3,[12][13][14][15][16]. This involvement is generally clinically quiescent until the late stages of the disease, when it can lead to death from congestive heart failure.…”

Section: Introductionmentioning

confidence: 99%