1990
DOI: 10.1016/0014-2999(90)90002-n
|View full text |Cite
|
Sign up to set email alerts
|

Cardiac inotropic responses to calcium and forskolin are not altered by prolonged isoproterenol infusion

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
3
0

Year Published

1996
1996
2007
2007

Publication Types

Select...
5

Relationship

1
4

Authors

Journals

citations
Cited by 8 publications
(4 citation statements)
references
References 27 publications
1
3
0
Order By: Relevance
“…These findings suggest homologous desensitization of adenylate cyclase activity following chronic h-AR activation. This notion is consistent with results showing neither a reduction in the inotropic and adenylate cyclasestimulating effects of forskolin (Bowling et al, 1990;Giannuzzi et al, 1995), nor with inhibition of adenylate cyclase responses to sodium fluoride (Iaccarino et al, 1999) following chronic adrenergic activation. Nevertheless, previous studies have reported a decrease in the stimulatory effects of forskolin accompanying a reduction in isoproterenol-induced myocardial adenylate cyclase activation in ISO-treated rats (Hakamata et al 1997).…”
Section: Discussionsupporting
confidence: 89%
“…These findings suggest homologous desensitization of adenylate cyclase activity following chronic h-AR activation. This notion is consistent with results showing neither a reduction in the inotropic and adenylate cyclasestimulating effects of forskolin (Bowling et al, 1990;Giannuzzi et al, 1995), nor with inhibition of adenylate cyclase responses to sodium fluoride (Iaccarino et al, 1999) following chronic adrenergic activation. Nevertheless, previous studies have reported a decrease in the stimulatory effects of forskolin accompanying a reduction in isoproterenol-induced myocardial adenylate cyclase activation in ISO-treated rats (Hakamata et al 1997).…”
Section: Discussionsupporting
confidence: 89%
“…Authors who used DP max or dP/dt max as indices of contractile capacity in the same model 13,14,16,17 concluded that the contractile state of the ISO‐induced cardiac hypertrophy was enhanced because DP max or dP/dt max was higher in these hearts than in control. Nevertheless, most studies in which force was evaluated from muscle strips 8–12 have shown that force generation is impaired in this model, indicating that the contractile state is depressed. There is only one report 18 of contraction improvement among the studies in which muscle strips were used.…”
Section: Discussionmentioning
confidence: 88%
“…According to authors 4–7 who have studied heart pumping ability, depression of the ejection function occurs in ISO‐induced hypertrophy. An equivalent opinion regarding depressed contractile ability was reported by those 8–12 who evaluated the capacity of isolated muscle to develop force. In contrast, others who evaluated systolic function in isolated heart preparations consider ISO hypertrophy to be accompanied by contractile function enhancement.…”
Section: Introductionmentioning
confidence: 93%
“…Changes in the density and function of L-type voltage-sensitive calcium channels have been reported in the myocardium of patients with end-stage heart failure and in animal models of this syndrome. There are no clear explanations for these cellular changes, but exposure of excitable systems to overactivation or decreased stimulation is now fully established to result in the compensatory processes described as desensitization (downregulation) or supersensitization (upregulation), respectively (10,28,31,32,88). The cellular signal responsible for the changes in L-type calcium channel density awaits definition; however, from the available data to date it appears that changes in these channels do not take place early in the development of cardiovascular disease.…”
Section: Discussionmentioning
confidence: 99%