Cardiac Inflammatory Myofibroblastic Tumor

Abstract

Although inflammatory myofibroblastic tumors (IMTs) can be found in virtually every major organ, cardiac origin is rare. After recently providing care to a child who presented with a significant myocardial infarction, interest in this rare tumor was piqued. We describe a comprehensive review of cardiac IMT, including information on nomenclature, epidemiology, clinical features, pathogenesis, gross/histological features, immunohistochemical profile, diagnosis, treatment, and prognosis. Fifty-seven cases were identified in the literature. Interestingly, our case represents the seventh case of coronary artery involvement reported. Moreover, it was found that an initial presentation of sudden death most commonly involves the coronary arteries.

Inflammatory myofibroblastic tumor of the pericardium in an 11‐month‐old infant: A case report

“…In special cases, cardiac surgical intervention such as valve replacement and valvular or vascular reconstruction may be required, and polytetrafluoroethylene grafts are used for bypass grafting. When the tumor is aggressive or there is recurrence in the heart, transplantation may be considered 13 . Based on a good surgical resection and normal post‐resection CT and MRI results, our patient received only ASA and corticosteroids.…”

Echocardiographic Findings in Children with Native Mitral Valve Masses Complicated by Systemic Embolization

“…12 Intracardiac presentations are extremely rare and have a predilection for right-sided cardiac structures. 13 Left-sided intracardiac IMT has been described only in case reports and literature reviews. We found seven case reports of intracardiac IMT involving the mitral valve.…”

“…[14][15][16][17][18][19][20] When we broadened our literature search to include all locations of cardiac IMT, we found two case reports describing systemic embolic phenomenon. 14,21 Eilers et al 13 reviewed 57 published cases of cardiac IMT and found that cardiac IMT occurs throughout the life span but is most commonly found during the pediatric years, with a slight female predominance and most commonly on the right side. Cardiac or constitutional symptoms were described at the most frequent primary presentation.…”

Myocardial Infarction Secondary to Inflammatory Myofibroblastic Tumor Obstruction of the Left Main: Treated With Primary PCI

“…A previous publication of this case was reported in World Journal of Pediatric Congential Heart Surgery describing the surgical perspective while this publication was focused on the coronary intervention aspect ( 2 ). When the patient presented with STEMI and a large mass was seen in the LVOT on echocardiogram, the initial diagnosis was embolized vegetation.…”