Cardiac Imaging of Acute Myocarditis Following COVID-19 mRNA Vaccination

Kim, In Cheol; Kim, Hyungseop; Lee, Hee Jeong; Kim, Ji Yoon; Kim, Jin Young

doi:10.3346/jkms.2021.36.e229

Cited by 24 publications

(30 citation statements)

References 11 publications

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“…Among case reports, three studies 59,83,84 received a perfect score (8/8 score) and three studies 37,52,56 had the lowest score (4/8), with an overall mean score of 6.37. The highest scoring criteria were reporting the current clinical condition of patients on presentation and clear reporting of the diagnostic tests or assessment methods (43/43, 100%) and description of the adverse events (harms) or unanticipated events (42/43, 97.67%).…”

Section: Resultsmentioning

confidence: 99%

Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Fazlollahi

Zahmatyar

Noori

et al. 2021

Reviews in Medical Virology

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There have been several local and systemic adverse events associated with mRNA COVID-19 vaccines. Pericarditis, myocarditis and myocardial infarction are examples of cardiac complications related to these vaccines. In this article, we conducted a systematic review of case reports and case series to identify the clinical profile, investigations, and management of reported cardiac complications post-mRNA COVID-19 vaccines. We systematically searched PubMed, Scopus, Web of Science, and Google Scholar, as well as the medRxiv preprint server, with terms including: 'SARS-CoV-2', 'COVID-19', 'messenger RNA vaccine*', 'mRNA-1273 vaccine', 'BNT162 vaccine', 'myocarditis', 'pericarditis', 'stroke' and 'Myocardial Ischemia' up to 25 September 2021. Studies were excluded if they were not case reports or case series, or reported cases from non-mRNA vaccines. Case reports and case series were included that investigated the potential cardiac complications associated with mRNA COVID-19 vaccines. The JBI checklist was used to assess quality and data synthesis was conducted using a qualitative methodology called narrative synthesis. Sixty-nine studies, including 43 case reports and 26 case series, were included. Myocarditis/myopericarditis and pericarditis were the most common adverse events among the 243 reported cardiac complications, post mRNA COVID-19 vaccination. Males with a median age of 21 years had the highest frequency of myocarditis. Almost three quarters (74.4%) of cases with myocarditis had received the BNT162b2 vaccine and 87.7% had received the second dose of the vaccine.Chest pain (96.1%) and fever (38.2%) were the most common presentations. CK-MB, troponin, and NT-proBNP were elevated in 100%, 99.5% and 78.3% of subjects, respectively. ST-segment abnormality was the most common electrocardiogram feature. Cardiac magnetic resonance imaging, which is the gold-standard approach for diagnosing myocarditis, was abnormal in all patients diagnosed with

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Section: Resultsmentioning

confidence: 99%

Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Fazlollahi

Zahmatyar

Noori

et al. 2021

Reviews in Medical Virology

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“…Subsequently, 10 studies were excluded for the following reasons: inclusion of pediatric cases (n=7) [20] , [21] , [22] , [23] , [24] , [25] , [26] , diagnosis of multisystem inflammatory syndrome (n=1) [27] , analysis of incidence data of a pharmacovigilance database (n=1) [28] and opinion paper (n=1) [29] . Therefore, 39 studies were included; 37 of them [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] provided individual data of 86 participants, forming the pooled cohort. On the other hand, 2 observational studies [67] , [68] reported aggregated data of 43 patients.…”

Section: Resultsmentioning

confidence: 99%

Myocarditis following mRNA Covid-19 vaccination: A pooled analysis

Bellos

Karageorgiou

Viskin

2022

Vaccine

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“…After reviewing individual abstracts and full texts of the articles, we identified 20 studies (12 case reports and 8 case series) that met the inclusion criteria for this systematic review. 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 In addition, we carried out an additional search in the same databases on September 10, 2021, and added one case series and three case reports. 30 , 31 , 32 , 33 The search terms used are described in detail in Table S2 .…”

Section: Methodsmentioning

confidence: 99%

Clinical characteristics and prognostic factors of myocarditis associated with the mRNA COVID‐19 vaccine

Woo

Kim

Yon

et al. 2021

Journal of Medical Virology

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To analyze the clinical presentation and outcomes of myocarditis after administration of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccine. Nine case series and 15 case reports (74 patients) of myocarditis after administration of the BNT162b2 or mRNA-1273 vaccine were reviewed from PubMed, Scopus, Embase, and Web of Science. We analyzed clinical manifestations, diagnostic findings, and outcomes. In addition, we performed a pooled analysis and investigated risk factors leading to admission to the intensive care unit and recovery with conservative care. Most patients were male (94.6%), and the median age (range) was 17.6 (14-70) years. Patients who received the BNT162b2 (n = 58, 78.4%) vaccine presented fewer systemic symptoms and left ventricular dysfunction than mRNA-1273 recipients. Although patients under 20 years experienced more fever and myalgia, they had better ejection fraction and less prominent myocardial inflammation in magnetic resonance imaging than older patients. The clinical course of all patients was favorable without mortality, and onethird of patients resolved with conservative care alone. Risk factor analyses revealed that patients with gastrointestinal symptoms required intensive care

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Cardiac Imaging of Acute Myocarditis Following COVID-19 mRNA Vaccination

Cited by 24 publications

References 11 publications

Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Myocarditis following mRNA Covid-19 vaccination: A pooled analysis

Clinical characteristics and prognostic factors of myocarditis associated with the mRNA COVID‐19 vaccine

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