Cardiac hypertrophy. Mechanical, neural, and endocrine dependence.

Morgan, Howard E.; Baker, Kenneth M.

doi:10.1161/01.cir.83.1.13

Cited by 532 publications

(222 citation statements)

References 102 publications

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“…The activation of adenylyl cyclase induces an increase in cAMP levels, which in turn activates PKA (14,19,50,51). In addition, a previous report indicated that down-regulation of G s␣ abolishes ISO-induced ERK activation in human endothelial cells (25), suggesting that G s␣ is required for activation of ERKs by ␤-AR.…”

Section: Discussionmentioning

confidence: 96%

“…Regarding ␤-AR-induced signaling pathways, stimulation of ␤-AR activates adenylyl cyclase through a different G protein, G s . Activation of adenylyl cyclase produces a second messenger cyclic adenosine monophosphate (cAMP), leading to activation of cAMP-dependent protein kinase (PKA) (14). PKA activation is important for the control of cell growth and differentiation.…”

mentioning

confidence: 99%

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Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy

Zou¹,

Komuro²,

Yamazaki³

et al. 1999

Journal of Biological Chemistry

150

116

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Activation of ␤-adrenoreceptors induces cardiomyocyte hypertrophy. In the present study, we examined isoproterenol-evoked intracellular signal transduction pathways leading to activation of extracellular signalregulated kinases (ERKs) and cardiomyocyte hypertrophy. Inhibitors for cAMP and protein kinase A (PKA) abolished isoproterenol-evoked ERK activation, suggesting that G s protein is involved in the activation. Inhibition of G i protein by pertussis toxin, however, also suppressed isoproterenol-induced ERK activation. Overexpression of the G ␤␥ subunit binding domain of the ␤-adrenoreceptor kinase 1 and of COOH-terminal Src kinase, which inhibit functions of G ␤␥ and the Src family tyrosine kinases, respectively, also inhibited isoproterenol-induced ERK activation. Overexpression of dominant-negative mutants of Ras and Raf-1 kinase and of the ␤-adrenoreceptor mutant that lacks phosphorylation sites by PKA abolished isoproterenol-stimulated ERK activation. The isoproterenol-induced increase in protein synthesis was also suppressed by inhibitors for PKA, G i , tyrosine kinases, or Ras. These results suggest that isoproterenol induces ERK activation and cardiomyocyte hypertrophy through two different G proteins, G s and G i . cAMP-dependent PKA activation through G s may phosphorylate the ␤-adrenoreceptor, leading to coupling of the receptor from G s to G i . Activation of G i activates ERKs through G ␤␥ , Src family tyrosine kinases, Ras, and Raf-1 kinase.

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Section: Discussionmentioning

confidence: 96%

mentioning

confidence: 99%

Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy

Zou¹,

Komuro²,

Yamazaki³

et al. 1999

Journal of Biological Chemistry

150

116

View full text Add to dashboard Cite

show abstract

“…In the other target organs (the heart), it has been reported that the regression of left ventricular hypertrophy depends on not only blood pressure levels, but also the reduction of cardiac sympathetic drive. 25 Therefore, we think that chronic sympathetic nerve activation influences target organ damage even when patients are not hypertensive.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure variability and prognosis in acute ischemic stroke with vascular compression on the rostral ventrolateral medulla (RVLM)

et al. 2011

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“…The results of in vitro studies indicate that mechanical stretching is the primary stimulus responsible for induction of increased cardiac myocyte protein synthesis and hypertrophy. 32 We therefore hypothesized that removal of the excess mechanical stimulus applied to the LV is one of the mechanisms responsible for attenuation of remodelling. Indeed, in this study, when ANCOVA was carried out using baPWV and SBP as covariates, the difference in RWT was abolished.…”

Section: Arterial Stiffnessmentioning

confidence: 99%

Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling

et al. 2009

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Arterial stiffening, hypertension and left ventricular (LV) remodelling are associated with increased risk of cardiovascular disease. Cardiorespiratory fitness is associated with cardiovascular function and reduced risk of cardiovascular disease. This cross-sectional study was carried out to determine the relationships between cardiorespiratory fitness, arterial stiffness, blood pressure (BP) and LV remodelling in women. On the basis of peak oxygen uptake, a total of 159 premenopausal (young) and postmenopausal (older) women were categorized into either low (unfit) or high (fit) cardiorespiratory fitness groups. The arterial stiffness and LV remodelling were measured by brachialankle pulse wave velocity (baPWV) and carotid augmentation index (AI) and LV relative wall thickness (RWT). Two-way analysis of variance indicated a significant interaction between age and cardiorespiratory fitness in baPWV, carotid AI, BP and RWT. In the older group, arterial stiffness (baPWV; 1401 ± 231 vs 1250 ± 125 cm s -1 , Po0.01, AI; 32.9±9.9 vs 24.8±10.1%, Po0.01), systolic blood pressure (SBP) (130 ± 22 vs 117 ± 15 mm Hg, Po0.01) and RWT (0.47 ± 0.08 vs 0.42±0.04, Po0.05) in fit women were lower than in unfit women. In older women, RWT was significantly related to baPWV (r ¼ 0.46, Po0.01), carotid AI (r ¼ 0.29, Po0.05), SBP (r ¼ 0.57, Po0.01) .V 2peak (r ¼ À0.32, Po0.05). In young women, they were not significant correlations, except for a weak correlation between RWT and SBP (r ¼ 0.21, Po0.05). These results suggest that higher cardiorespiratory fitness is associated with lower arterial stiffness, BP and RWT in older women.

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Cardiac hypertrophy. Mechanical, neural, and endocrine dependence.

Cited by 532 publications

References 102 publications

Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy

Both Gs and Gi Proteins Are Critically Involved in Isoproterenol-induced Cardiomyocyte Hypertrophy

Blood pressure variability and prognosis in acute ischemic stroke with vascular compression on the rostral ventrolateral medulla (RVLM)

Age and cardiorespiratory fitness are associated with arterial stiffening and left ventricular remodelling

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