Cardiac hypertrophy and remodeling in relation to ACE and angiotensinogen genes genotypes in Chinese dialysis patients

Wang, Angela Yee-Moon; Chan, Juliana C.N.; Wang, Mei; Poon, Emily; Lui, Siu‐Fai; Li, Philip Kam-Tao; Sanderson, John E.

doi:10.1046/j.1523-1755.2003.00933.x

Cited by 40 publications

(34 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…37 A study by Ortlepp and col leagues in 26 family members carrying a single mutation in the MyBPC gene revealed a significant association between the angiotensinogen polymorphism and cardiac hypertrophy. 17 Moreover, studies in Chinese, 65 South Korean 66 and Japanese patients 67 found an association between the CC genotype and cardiac hypertrophy. In con trast, the extent of hypertrophy in 108 unrelated Canadian patients was not influenced by angiotensinogen genotype.…”

Section: Angiotensinogenmentioning

confidence: 97%

Impact of polymorphisms in the renin–angiotensin–aldosterone system on hypertrophic cardiomyopathy

Orenes‐Piñero

Hernández-Romero

Jover

et al. 2011

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

Hypertrophic cardiomyopathy (HCM) is a clinically heterogeneous autosomal dominant heart disease characterised by left ventricular hypertrophy in the absence of another cardiac or systemic disease that is capable of producing significant wall thickening. Microscopically it is characterised by cardiomyocyte hypertrophy, myofibrillar disarray and fibrosis. The phenotypic expression of HCM is multifactorial, with the majority of cases occurring secondary to mutations in genes encoding the sarcomere proteins. In conjunction with the genetic heterogeneity of HCM, phenotypic expression also exhibits a high level of variability even within families with the same aetiological mutation, and may be influenced by additional genetic factors. Polymorphisms of the renin-angiotensin-aldosterone system (RAAS) represent an attractive hypothesis as potential disease modifiers, as these genetic variants alter the 'activation status' of the RAAS, which leads to more left ventricular hypertrophy through different pathways. The main objective of this review is to provide an overview of the role of different polymorphisms identified in the RAAS, in patients with HCM.

show abstract

Section: Angiotensinogenmentioning

confidence: 97%

Impact of polymorphisms in the renin–angiotensin–aldosterone system on hypertrophic cardiomyopathy

Orenes‐Piñero

Hernández-Romero

Jover

et al. 2011

J Renin Angiotensin Aldosterone Syst

View full text Add to dashboard Cite

show abstract

“…Influence of the М235Т polymorphism of the AGT gene on HT was also studied [16][17][18]. A few works study impact of this polymorphism on LVH development [19][20][21]. Our study showed correlation of the М235Т polymorphism of the AGT gene with LVH development in HT patients: the MM genotype was observed in patients with LVH more seldom than in HT patients without it (12% vs 21%, р=0,0187).…”

Section: Clinical and Genetic Factors Of Left Ventricular Hypertrophymentioning

confidence: 55%

“…Полиморфизм М235Т гена AGT также изучался в большей степени в его влиянии на развитие АГ [16][17][18]. Небольшое количество работ посвящено изучению влияния данного полимор-физма на развитие ГЛЖ [19][20][21]. В нашем исследовании обнаружена взаимосвязь развития ГЛЖ у больных АГ и полиморфизма М235Т гена AGT: генотип ММ встречал-ся меньше при ГЛЖ, чем у больных АГ без ГЛЖ (12% про-тив 21%, р=0,0187), а в возрасте до 50 лет -8% про-тив 21% (р=0,018).…”

Section: Clinical and Genetic Factors Of Left Ventricular Hypertrophyunclassified

Association of Clinical and Genetic Factors With Left Ventricle Hypertrophy in Arterial Hypertension

Kuznetsova

Gavrilov²,

Rebrikov

et al. 2010

Racionalʹnaâ farmakoterapiâ v kardiologii

View full text Add to dashboard Cite

Aim. To evaluate association of clinical and genetic factors with left ventricle hypertrophy (LVH) in patients with arterial hypertension (HT).Materials and methods. 672 patients with HT were involved, aged 50,6 y.o. in average, men 67%. Laboratory assays, ECG, echocardiography were performed. Control group included 184 healthy persons. Genotyping with single-nucleotide substitutions of the endothelial NO synthase (eNOS) Glu298Asp gene, the C242T of the NADPH oxidase p22phox subunit and the angiotensin 2 receptor type 1 А1166С gene was carried out using a polymerase chain reaction (PCR) with evaluating of restriction fragments length polymorphism, while with substitutions of the angiotensinogen М235Т, G(-6)A gene allele-specific PCR "in real time" was applied.Results. LVH was found in 39% of patients. It was more frequent in persons above 50 years old (OR 2,8, р<0,0001), in men (OR 1,43, p=0,035), in HT of degree 2-3 (OR 3,35, р<0,0001), HT duration more than 5 years (OR 2,52, р<0,05), in obesity (OR 1,57, р=0,005) or diabetes (OR 3,33, р<0,0001) presence. At genetic factors evaluation decrease of LVH risk was revealed in persons with the MM polymorphism of the angiotensinogen М235Т gene (OR 0,506, р=0,0187). Association of the MM genotype with LVH risk lowering was more obvious at the young age (OR 0,31, р=0,018). The A allele of the eNOS gene Glu298Asp polymorphism increased risk of LVH development when HT was diagnosed in the young age (OR 1,98, р=0,037) and in women up to 50 years old (OR 2,34, р=0,027). The T allele of the p22phox NADPH oxidase gene С242Т polymorphism correlated with LVH risk reduction in HT patients up to 50 years old (OR 0,6, p=0,01), the C allele -with increase of it (OR 1,66, р=0,01), this influence was more noticeable in women up to 50 years old (T allele -OR 0,21; C allele -OR 4,57, p=0,001). Conclusion. Hypertensive LVH correlates with age, male gender, HT degree and duration, obesity and diabetes mellitus. Genetic factors were less associated with LVH. Цель. Анализ ассоциации клинических и генетических факторов с гипертрофией левого желудочка (ГЛЖ) у пациентов с артериальной гипертонией (АГ). Материал и методы. Обследованы 672 пациента АГ, средний возраст 50,6 лет, мужчин 67%. Выполнялись лабораторные исследования, ЭКГ, эхокардиография. Группу контроля состави-ли 184 человека. Генотипирование по однонуклеотидным заменам Glu298Asp гена эндотелиальной NO синтазы, С242Т субъединицы p22phox NADPH оксидазы и А1166С гена рецептора 1 типа к ангиотензину 2 проводилось методом полимеразной цепной реакции (ПЦР) с анализом полиморфизма длины рестрикционных фрагментов, а по заменам М235Т, G(-6)A гена ангио-тензиногена с помощью аллель-специфичной ПЦР «в реальном времени». Результаты. ГЛЖ диагностирована у 39% больных, чаще в возрасте старше 50 лет (ОШ 2,8, р<0,0001), у мужчин (ОШ 1,43, р=0,035), при наличии 2-3 степени АГ (ОШ 3,35, р<0,0001), давности АГ более 5 лет (ОШ 2,52, p<0,05), при наличии ожирения (ОШ 1,57, р=0,005), сахарного диабета (ОШ 3,33, р<0,0001). При анализе генетических факто...

show abstract

“…Regarding the AGT M235T polymorphism, although it has been reported to be associated with plasma AGT, hypertension, cardiac hypertrophy and coronary artery disease, 15,22 limited reports have discussed its relationship with arrhythmia. 34 Recently, Raizada et al reported no association of AGT M235T polymorphism with QT parameters among patients with end stage renal disease, based on a cross-sectional study.…”

Section: Discussionmentioning

confidence: 99%

D-Allele of ACE Polymorphism is Associated With Increased Magnitude of QT Dispersion Prolongation in Elderly Chinese 4-Year Follow-up Study

Lin

Chiu

et al. 2007

Circ J

View full text Add to dashboard Cite

he frequency of arrhythmia increases with age, probably because of age-associated degenerative changes in the conduction system, as well as myocardial fibrosis. 1 Ventricular repolarization abnormality plays an important role in the occurrence of arrhythmia. The QT interval and QT dispersion (QTd), 2 of the repolarization parameters, are prolonged with increasing age, which may contribute to an increased risk of ventricular arrhythmias and cardiac mortality in elderly patients. 2 Several large prospective studies have assessed the predictive value of QTd and corrected QT interval (QTc) dispersion (QTcd) for cardiac and all-cause mortality, 3,4 and their results suggest that long QTd and QTcd are associated with cardiovascular morbidity and mortality. More recently, transmural dispersion of repolarization (TDR) has been evaluated by measuring the interval between the peak and the end of the T wave (Tpe), as well as the Tpe interval divided by the QT interval (Tpe/QT) ratio, creating 2 new repolarization parameters. 5,6 These increased TDR-related parameters were Circulation Journal Vol. 71, January 2007 found to be associated with the occurrence of arrhythmias, such as torsades de pointes in long QT syndrome. 6 Furthermore, a cross-sectional study showed that TDR parameters increased with age. 7 Therefore, it is mandatory to determine the risk factors in the elderly that may predispose to prolongation of these repolarization parameters.The renin -angiotensin system (RAS) is involved in many cardiovascular diseases. Carriers of the D-allele of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism display elevated serum and cardiac ACE activity and thus may have higher RAS system activation. 8,9 Therefore, the D-allele carriers are exposed to a higher level of angiotensin II than non-D allele carriers. Compelling studies report that the ACE D-allele is associated with myocardial infarction, sudden death and malignant ventricular arrhythmia. [10][11][12] Furthermore, the D-allele has been associated with QTd in hypertensive subjects or survivors of myocardial infarction. 13,14 Angiotensinogen (AGT) M235T polymorphism is associated with plasma AGT levels that increase stepwise according to the number of T alleles present. 15 The T allele has very different distributions in Asians (70-73%) and Caucasians (10-24%). 16,17 One study showed that homozygosity for the T allele was associated with increased risk of cardiovascular diseases, such as hypertension, coronary artery disease and myocardial infarction. 15 To our knowledge, the influence of gene polymorphisms on QTd and TDR-related parameters has not been reported in a prospective cohort. We therefore conducted a prospective study to investigate several physiological parameters

show abstract

Cardiac hypertrophy and remodeling in relation to ACE and angiotensinogen genes genotypes in Chinese dialysis patients

Cited by 40 publications

References 56 publications

Impact of polymorphisms in the renin–angiotensin–aldosterone system on hypertrophic cardiomyopathy

Impact of polymorphisms in the renin–angiotensin–aldosterone system on hypertrophic cardiomyopathy

Association of Clinical and Genetic Factors With Left Ventricle Hypertrophy in Arterial Hypertension

D-Allele of ACE Polymorphism is Associated With Increased Magnitude of QT Dispersion Prolongation in Elderly Chinese 4-Year Follow-up Study

Contact Info

Product

Resources

About