Cardiac Hemolysis and Anemia Refractory to Erythropoietin: On Anemia in Dialysis Patients

Increasing Erythropoietin Dose Overcomes Inadequate Erythropoietin Response Secondary to Cardiac Hemolysis

“…This patient presented with severe anemia and required, on average, 2 blood units every 6 weeks in spite of EPO therapy at a dose of 300 UI/kg/week i.v. [3]. Here we report on another patient in which the inadequate response to EPO was related to cardiac prostheses.…”

HEMATOLOGY: ISSUES IN THE DIALYSIS PATIENT: Erythropoietin Resistance in the Treatment of the Anemia of Chronic Renal Failure

“…Dramatic resistance to EPO therapy has been documented in patients who develop anti‐N‐form hemolysis (51). The anti‐N‐form antibody is produced in some dialysis patients as an immune response to formaldehyde‐altered Hgb as an untoward reaction to dialyzer reuse.…”