Cardiac hemodynamics and proinflammatory cytokines during biatrial and right atrial appendage pacing in patients with interatrial block

Rubaj, Andrzej; Ruciński, Piotr; Kutarski, Andrzej; Dąbrowska−Kugacka, Alicja; Oleszczak, Krzysztof; Zimoń, Barbara; Trojnar, Marcin; Zapolski, Tomasz; Drozd, Jakub; Tarkowski, Adam; Wysokiński, Andrzej

doi:10.1007/s10840-013-9792-8

Cited by 10 publications

(9 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Barani et al (11) examined inflammatory factors in patients with critical limb ischemia and found a significantly higher serum NPT levels in those with AF than in patients in sinus rhythm. Rubaj et al (37) reported a significant decrease in NPT levels at 1 week of biatrial pacing in comparison to right atrial appendage pacing.…”

Section: Discussionmentioning

confidence: 99%

Neopterin and interleukin-6 as predictors of recurrent atrial fibrillation

et al. 2015

View full text Add to dashboard Cite

Objective:Available evidence suggests that inflammation may be associated with atrial fibrillation (AF). This prospective and observational study aimed to assess whether plasma neopterin (NPT) and interleukin-6 (IL-6) levels before and after electrical cardioversion (CV) predict AF recurrence.Methods:The study was designed as a prospective observational trial. Blood samples were collected (24 hours before, 24 h after CV, and 7 days after CV) in 60 patients with a dual-chamber pacemakar and preserved left ventricular systolic function who underwent successful CV of persistent AF. All significant parameters associated with AF recurrence lasting ≥30 min and detected by pacemaker data logs were evaluated in multivariate logistic regression analysis. Echocardiography was performed 7 days after CV in patients with sinus rhythm. The control group included 17 subjects without AF.Results:The analysis included 51 patients who remained in sinus rhythm 7 days after CV. During 12 months of follow-up, AF recurred in 46 patients. Baseline IL-6 levels did not differ between the two groups, but baseline NPT levels were higher in the study group than in the control group (19±7 vs. 11±5 nmol/mL, p<0.001). NPT levels of ≥14.6 nmol/L at baseline and ≥13.3 nmol/L 7 days after CV separated the patients with AF recurrence from those without arrhythmia after CV. Only left atrial emptying fraction <38% was an independent predictor of AF recurrence (p=0.03), whereas NPT levels of ≥13.3 nmol/L 7 days after CV showed borderline statistical significance (p=0.07).Conclusion:Increased NPT level was observed in patients with persistent AF. Neither baseline IL-6 and NPT levels nor their changes within 7 days after CV were predictive of AF recurrence. Further studies are needed to establish the prognostic significance of NPT in patients with AF. (Anatol J Cardiol 2016; 16: 563-71) 0000; 00: 000–000

show abstract

Section: Discussionmentioning

confidence: 99%

Neopterin and interleukin-6 as predictors of recurrent atrial fibrillation

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In another study by Rubaj et al, the authors sought to determine whether biatrial pacing improves cardiac hemodynamic function and reduces serum concentrations of inflammatory mediators in patients with IAB [43]. Twenty-eight patients with IAB and preserved AV conduction were evaluated under both BiA and RAA pacing.…”

Section: Biatrial Pacing In Iabmentioning

confidence: 99%

Bayés’ syndrome: the association between interatrial block and supraventricular arrhythmias

Conde

Seoane

Gysel

et al. 2015

Expert Review of Cardiovascular Therapy

View full text Add to dashboard Cite

The past few years have given rise to extensive research on atrial conduction disorders and their clinical relevance. Most notably, an association between interatrial block and supraventricular arrhythmias has been discovered. This disorder, recently termed 'Bayés' syndrome', has important clinical implications. In this article, the authors review normal atrial conduction and associated disorders. A particular focus is placed on Bayés' syndrome and the relationship between interatrial block and supraventricular arrhythmias in different clinical scenarios. The report also outlines the current progress in the study of this syndrome and highlights areas requiring further investigation.

show abstract

“…Importantly, it has been suggested that NPs including TiO 2 NPs can be translocated to heart, cause myocardial dysfunction, oxidative stress, cardiac inflammation and atherosclerosis in mice, induce plaque progression in aorta of mice, endothelial inflammatory response in primary vascular endothelial cells, and cardiac infarction in rats . As known, cardiac inflammation adversely affects cardiopulmonary hemodynamics in animals and human . Hemodynamics is a hydrodynamic problem for studying the flow of blood in the cardiovascular system, its basic research object is the relationship between flow resistance and pressure, and studies the effect of drugs on the cardiac function of the organism, pharmacological effects, and mechanisms of cardiovascular drugs.…”

Section: Introductionmentioning

confidence: 99%

Titanium dioxide nanoparticle-induced dysfunction of cardiac hemodynamics is involved in cardiac inflammation in mice

Hong

Zhao

et al. 2016

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

In the past two decades, titanium dioxide nanoparticles (TiO NPs) have been extensively used in medicine, food industry and other daily life, while their possible interactions with the their influence and human body on human health remain not well understood. Thus, the study was designed to examine whether long-term exposure to TiO NPs cause myocardial dysfunction which is involved in cardiac lesions and alter expression of genes and proteins involving inflammatory response in the mouse heart. The findings showed that intragastric feeding for nine consecutive months with TiO NPs resulted in titanium accumulation, infiltration of inflammatory cells and apoptosis of heart, reductions in net increases of body weight, cardiac indices of function (LV systolic pressure, maximal rate of pressure increase over time, maximal rate of pressure decrease over time and coronary flow), and increases in heart indices, cardiac indices of function (LV end-diastolic pressure and heart rate) in mice. TiO NPs also decreased ATP production in the hearts. Furthermore, TiO NPs increased expression of nuclear factor-κB, interleukin-lβ and tumour necrosis factor-α, and reduced expression of anti-inflammatory cytokines including suppressor of cytokine signaling (SOCS) 1 and SOCS3 in the cardiac tissue. These results suggest that TiO NPs may modulate the cardiac function and expression of inflammatory cytokines. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2917-2927, 2016.

show abstract

Cardiac hemodynamics and proinflammatory cytokines during biatrial and right atrial appendage pacing in patients with interatrial block

Cited by 10 publications

References 43 publications

Neopterin and interleukin-6 as predictors of recurrent atrial fibrillation

Neopterin and interleukin-6 as predictors of recurrent atrial fibrillation

Bayés’ syndrome: the association between interatrial block and supraventricular arrhythmias

Titanium dioxide nanoparticle-induced dysfunction of cardiac hemodynamics is involved in cardiac inflammation in mice

Contact Info

Product

Resources

About