Cardiac Haemodynamics under β-Receptor Blockade in Dogs

Gander, M; Veragut, U.P.; Köhler, Robin; Lüthy, E.

doi:10.1159/000168955

Cited by 12 publications

(3 citation statements)

References 5 publications

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“…The dose of propranolol employed in this study, that is, 0.5 mg/kg body wt, is used commonly to produce beta receptor blockade in experimental animals [7], although this dose is considerably larger than the ones employed for clinical purposes [13][14][15][16][17][18][19]. Because the total body surface area relative to body weight is greater in the immature than the mature animal, a fixed dose of propranolol based on body weight is believed to be pharmacologically smaller in the immature animal [21].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Effects of Propranolol in Intact Puppies and Adult Dogs

Truccone

Levine

1973

Pediatr Res

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ExtractThe cardiovascular effects of propranolol (Inderal) [24] were compared in 13 adult dogs and 14 puppies. Left ventricular (LV) pressure was measured with a catheter tip manometer and myocardial contractility was assessed by LV measurements of peak rate of pressure development (LV dp/dt), LV dp/dt at 40 mm Hg LV pressure (P 40 dp/dt), and peak LV (dp/dt)/P. Cardiac output was measured by indocyanine green dye dilution. Measurements were made before and 5 min after intravenous propranolol (0.5 g/kg) administered over a period of 1 min. In the adult dog, propranolol produced a significant depression of cardiac index and peak LV systolic pressure, significant elevation of systemic resistance index and LV end-diastolic pressure, and a significant fall in indices of myocardial contractility. The changes in heart rate, cardiac index, peak LV systolic pressure, and contractility indices produced by propranolol were 2-4 times greater, on a percentage basis, in the puppies as in the adult dogs. The systemic resistance index and LV end-diastolic pressure changed similarly in both groups. The increased sensitivity of the puppies to propranolol appears to reflect a greater dependence on circulating catecholamines in the immature circulation. Speculation

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Section: Discussionmentioning

confidence: 99%

Cardiovascular Effects of Propranolol in Intact Puppies and Adult Dogs

Truccone

Levine

1973

Pediatr Res

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“…Withdrawal of sympathetic drive to the ventricles also reduces the speed of ventricular contraction, which may further reduce myocardial oxygen consumption (Sonnenblick et al, 1965a). Though it has been shown that the left ventricular volume and end-diastolic pressure are increased both at rest and during exercise in the non-ischaemic heart after beta-blockade (Sonnenblick et al, 1965b;Chamberlain, 1966;Gander et al, 1966;Majid et al, 1970), left ventricular filling pressure is often not increased during exercise in anginal patients after betablockade (Dwyer et al, 1968;Astrom, 1968;Sharma et al, 1970), probably due to the sparing effect of the reduced rate, pressure, and speed of contraction on the left ventricular myocardial oxygen consumption. By reducing myocardial oxygen demand and coronary blood flow requirements these factors outweigh any direct increase in coronary vascular resistance due to beta-blockade (Folle and Aviado, 1965;Klocke et al, 1965;McKenna et al, 1966;Whitsitt and Lucchesi, 1967).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Adrenergic Beta-blocking Drugs in Angina Pectoris

Sharma¹,

Meeran²,

Galvin³

et al. 1971

BMJ

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SummaryThe symptomatic, electrocardiographic, and haemodynamic effects of two adrenergic beta-blocking drugs, oxprenolol and propranolol, have been compared in equipotent intravenous doses in six patients with uncomplicated angina pectoris during treadmill exercise. The method of comparison included double-blind assessment and analysis with placebo control and randomized serial comparison in each patient. Both drugs produced an equal amelioration in symptoms in most of the patients. This was closely correlated with improvement in the electrocardiographic changes and a significant reduction in the exercising heart rate and systemic arterial pressure. This method of double-blind combined subjective and objective assessment carries distinct advantages in the comparative assessment of drug treatments in angina pectoris.Introduction Though a number of adrenergic beta-blocking drugs are available for the symptomatic treatment of severe angina pectoris there is little information on their comparative effectiveness. This report concerns a comparative study of the symptomatic, electrocardiographic, and circulatory effects of two such drugs, oxprenolol and propranolol, in patients with angina pectoris.

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“…Anaesthetised States The effects of beta-blockade induced during different forms of anaesthesia have been widely studied in the dog. Gander et al 60 administered propranolol 0.5 mg/kg intravenously to dogs anaesthetised with intravenous chloralose. Cardiac output fell by 35% and this change was accompanied by a decrease in heart rate and of the maximum rate of rise of left ventricular pressure (LV dP / dt max), while there was an increase in left ventricular end-diastolic volume (L VEDV).…”

Section: Animal Experiments In the A Wake Andmentioning

confidence: 99%

Beta-Adrenergic Blockade and Anaesthesia with Reference to Interactions with Anaesthetic Drugs and Techniques

Roberts

1980

Anaesth Intensive Care

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The introduction of the first clinically applicable beta-adrenergic receptor blocking agent (beta-blocker), pronethalol, by Black and Step hens on in 1962 1 heralded a new era in cardiovascular pharmacology. Since that time there has been a rapid increase both in the number of drugs of this type available to clinicians and in the number and variety of indications for their clinical use which now range from the prophylaxis of migraine headaches to the prevention of the deleterious effects of stage fright in musicians. However, their widest application has been in the treatment of hypertension and ischaemic heart disease. 2 ,3 It has therefore become increasingly common for patients receiving long-term therapy with a beta-blocker to present for anaesthesia and surgery. In addition it has been shown that the acute administration of a betablocker may be indicated in some potentially dangerous disturbances of cardiac rhythm caused by increased beta-adrenergic activity which may be encountered in anaesthetic practice. Such over activity may be due to an exaggerated endogenous response or to the administration of sympathomimetic substances by surgeon or anaesthetist.

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Cardiac Haemodynamics under β-Receptor Blockade in Dogs

Cited by 12 publications

References 5 publications

Cardiovascular Effects of Propranolol in Intact Puppies and Adult Dogs

Cardiovascular Effects of Propranolol in Intact Puppies and Adult Dogs

Comparison of Adrenergic Beta-blocking Drugs in Angina Pectoris

Beta-Adrenergic Blockade and Anaesthesia with Reference to Interactions with Anaesthetic Drugs and Techniques

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