Cardiac granulocytic sarcoma diagnosed by intracardiac echocardiography-guided biopsy

Koželj, Mirta; Zorman, Darko; Mrevlje, Blaž; Černelč, Peter; Zver, Samo

doi:10.1007/s12185-008-0104-5

Cited by 13 publications

(7 citation statements)

References 6 publications

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“…For example, in here presented case surgical decompression of spinal cord was undertaken at presentation due to progressive neurological deficit in the patient, even before the diagnosis of GS had been made. In most cases surgical resection of GS is not needed, even in unusual cases like the GS of the heart [6].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, 66-88% of patients with an isolated GS will develop AML at a mean of 9-11 months after diagnosis [5]. GS may involve any organ system, from more common involvement of the skin, bone, soft tissue of the head and neck (frequently the orbits) and lymph node, to rare cases involving heart or small intestines [2,[6][7][8]. The involvement of the central nervous system (CNS) is rare, and spinal cord compression by GS is even rarer [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Spinal epidural granulocytic sarcoma in non-leukemic patient

et al. 2008

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A previously healthy 24-year-old male presented with a 3-month history of progressive backache and weakness in both legs. Magnetic resonance imaging of the spine showed a large soft tissue mass infiltrating paraspinal musculature of lumbosacral area, sacral laminas, last lumbar and all sacral vertebra, protruding into the spinal canal, and with propagation into pelvis. Baseline laboratory data were normal. Decompressive laminectomy and tumor removal were performed resulting in neurological improvement. Histological examination identified granulocytic sarcoma (GS). Bone marrow biopsy showed normal findings. The patient underwent adjuvant chemotherapy and radiotherapy, resulting in the elimination of residual lesion, followed by autologous transplant. Immediate diagnosis and adequate systematic treatment are essential to achieve optimal results in patients with isolated GS. The patient is alive and free of the disease 14 months from the diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spinal epidural granulocytic sarcoma in non-leukemic patient

et al. 2008

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“…Moreover, 66-88% of patients with an isolated granulocytic sarcoma will develop AML at a mean of 9-11 months after diagnosis (16). Granulocytic sarcoma most commonly occurs in the soft tissues of the skin and bone, soft tissue of the head and neck (frequently the orbits), lymph node; rare cases involve the heart or small intestines and less often in the central nervous system and spinal cord (17)(18)(19). Involvement of the central nervous system (CNS) is rare, and spinal cord compression by granulocytic sarcoma is even more rare (8,9).…”

Section: F I G U R E 3 He Ma T O X Y L I N a N D E O S I N S T A I mentioning

confidence: 99%

Spinal Myeloid Sarcoma in Two Non-Leukemic Patients

et al. 2010

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Myeloid sarcoma, formerly termed granulocytic sarcoma or chloroma, consists of neoplastic granulocytic precursors and myeloblasts. Isolated chloromas (granulocytic sarcomas) are rare tumors. Spinal complications of chloromas, such as cord compression secondary to epidural tumor or cauda equine syndrome have been described but are rare. We herein report two cases with spinal granulocytic sarcomas in non-leukemic patients. The case of a previously healthy 22-year-old man diagnosed with multiple spinal granulocytic sarcomas with no evidence of bone marrow or other hematological involvement is described. And, a 43-year-old woman diagnosed cervical spinal granulocytic sarcoma with no evidence of bone marrow or other hematological involvement is described. The tumor was totally removed by microsurgery. The histopathological examination was consistent with granulocytic sarcoma. Granulocytic sarcoma should be considered in the differential diagnosis of an epidural mass in patients with or without acute leukemia, because early diagnosis followed by appropriate combined chemotherapy and radiation may obviate surgical intervention and eventually prevent leukemic transformation.

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“…Common sites of MS include the skin, head and neck, brain and spinal cord, and breasts (6). A cardiac site with MS involvement is extremely rare, and treatment results for cardiac MS have only been addressed by a few studies (7)(8)(9)(10)(11)(12)(13)(14). Here, we report that an AML patient with isolated cardiac MS relapse after HSCT was successfully treated using fractionated radiotherapy and review studies on treatment modalities including chemotherapy and radiotherapy and treatment responses and outcomes of MS patients with cardiac involvement.…”

Section: Introductionmentioning

confidence: 99%

Complete response of myeloid sarcoma with cardiac involvement to radiotherapy

Yang¹,

Yao²,

Chen³

et al. 2016

J. Thorac. Dis.

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We present a rare case of intracardiac myeloid sarcoma (MS) of acute myeloid leukemia (AML) and who responds completely well to low-dose radiotherapy. This 19-year-old young man initially presented with AML and received standard chemotherapy followed by allogeneic hematopoietic stem cell transplantation (HSCT). However, he developed intracardiac isolated MS relapse with the presentation of exertional dyspnea and superior vena cava (SVC) syndrome 3 years later. He then received radiotherapy with 24 Gy at a 12 daily fractions using forward "field in field" intensity modulated radiotherapy technique. He dramatically had improved clinical symptoms, and complete remission was achieved one month after completing radiotherapy. Our result is in line with anecdotal case reports showed that radiotherapy with 15 Gy in 10 fractions or with 24 Gy in 12 fractions resulted in good response and less toxicity of 2 cases of MS with cardiac involvement. These results indicate that a modest radiotherapy dose, 24 Gy, achieves good local control of MS with cardiac involvement.

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Cardiac granulocytic sarcoma diagnosed by intracardiac echocardiography-guided biopsy

Cited by 13 publications

References 6 publications

Spinal epidural granulocytic sarcoma in non-leukemic patient

Spinal epidural granulocytic sarcoma in non-leukemic patient

Spinal Myeloid Sarcoma in Two Non-Leukemic Patients

Complete response of myeloid sarcoma with cardiac involvement to radiotherapy

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