Cardiac Function Estimation from MRI Using a Heart Model and Data Assimilation: Advances and Difficulties

Sermesant, Maxime; Moireau, Philippe; Cámara, Óscar; Sainte-Marie, Jacques; Andriantsimiavona, Rado; Cimrman, Robert; Hill, Derek L. G.; Chapelle, Dominique; Razavi, Reza

doi:10.1007/11494621_33

Cited by 37 publications

(42 citation statements)

References 19 publications

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“…Recently proposed physiology-based constitutive models consider the mechanism of the involuntary contractile behavior of cardiac muscle due to the action potential under calcium flux Sermesant et al, 2006;Chapelle et al, 2010). These formulations capture the characteristic energy dissipative process of the cardiomyocyte active contribution and satisfy the thermodynamics laws.…”

Section: Discussionmentioning

confidence: 99%

“…These formulations capture the characteristic energy dissipative process of the cardiomyocyte active contribution and satisfy the thermodynamics laws. However, these models are mathematically complex and lead to sophisticated procedures for the identification of the model parameters (Sermesant et al, 2006), making unrealistic the use of such models as design tools for MTF actuators. Instead, we take a simple, but effective phenomenological approach in the spirit of Blemker et al (2005) and Böl et al (2009), where the energy dissipative behavior of the active contribution is neglected.…”

Section: Discussionmentioning

confidence: 99%

“…The characteristic energy dissipative process of the cardiomyocyte active contribution can be captured by recently developed physiology-based models, which consider the mechanism of the involuntary contractile behavior of cardiac muscle due to the action potential under calcium flux Sermesant et al, 2006;Chapelle et al, 2010). However, this approach is mathematically complex, and model parameter identification is challenging.…”

Section: Cardiac Muscle Cellsmentioning

confidence: 99%

“…Cardiac muscle is, like skeletal muscle, characterized by highly organized striated myofibrils; however, it also exhibits spontaneous activity as well as mechanical, chemical, and electrical cell-to-cell coupling (functional syncytium) leading to through-conduction of impulses and, subsequently, a highly synchronous response. Recently, a few researchers Sermesant et al, 2006;Chapelle et al, 2010) proposed physiology-based models for cardiomyocytes, which considers the mechanism of the involuntary contractile behavior of cardiac muscle due to the action potential under calcium flux and captures the characteristic energy dissipative process of the cardiomyocyte active contribution. However, those physiologybased models are mathematically complex and the identification of the model parameters is very challenging.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior

Shim¹,

Grosberg²,

Nawroth³

et al. 2012

Journal of Biomechanics

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Recent progress in tissue engineering has made it possible to build contractile bio-hybrid materials that undergo conformational changes by growing a layer of cardiac muscle on elastic polymeric membranes. Further development of such muscular thin films for building actuators and powering devices requires exploring several design parameters, which include the alignment of the cardiac myocytes and the thickness/Young’s modulus of elastomeric film. To more efficiently explore these design parameters, we propose a 3-D phenomenological constitutive model, which accounts for both the passive deformation including pre-stretch and the active behavior of the cardiomyocytes. The proposed 3-D constitutive model is implemented within a finite element framework, and can be used to improve the current design of bio-hybrid thin films and help developing bio-hybrid constructs capable of complex conformational changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Cardiac Muscle Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior

Shim¹,

Grosberg²,

Nawroth³

et al. 2012

Journal of Biomechanics

View full text Add to dashboard Cite

show abstract

“…The heart geometry is simplified, based on intersecting ellipsoids, so that the fibers orientation can be parametrized in terms of analytical functions. We refer to Sermesant et al 49 for the details of the geometrical definition of the heart. Note that this simplified geometry only includes the ventricles.…”

Section: Anatomical Model and Computational Meshesmentioning

confidence: 99%

Mathematical Modeling of Electrocardiograms: A Numerical Study

et al. 2009

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This paper deals with the numerical simulation of electrocardiograms (ECG). Our aim is to devise a mathematical model, based on partial differential equations, which is able to provide realistic 12-lead ECGs. The main ingredients of this model are classical: the bidomain equations coupled to a phenomenological ionic model in the heart, and a generalized Laplace equation in the torso. The obtention of realistic ECGs relies on other important features--including heart-torso transmission conditions, anisotropy, cell heterogeneity and His bundle modeling--that are discussed in detail. The numerical implementation is based on state-of-the-art numerical methods: domain decomposition techniques and second order semi-implicit time marching schemes, offering a good compromise between accuracy, stability and efficiency. The numerical ECGs obtained with this approach show correct amplitudes, shapes and polarities, in all the 12 standard leads. The relevance of every modeling choice is carefully discussed and the numerical ECG sensitivity to the model parameters investigated.

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Diffusion Tensor Magnetic Resonance Imaging‐Derived Myocardial Fiber Disarray in Hypertensive Left Ventricular Hypertrophy: Visualization, Quantification and the Effect on Mechanical Function

et al. 2012

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International audienceLeft ventricular hypertrophy induced by systemic hypertension is generally regarded a morphological precursor of unfortunate cardiovascular events. Myocardial fiber disarray has been long recognized as a prevalent hallmark of this pathology. In this chapter, ex vivo diffusion tensor magnetic resonance imaging is employed to delineate the regional loss of myocardial organization that is present in the excised heart of a spontaneously hypertensive rat, as opposed to a control. Fiber tracking results are provided that illustrate in great detail the alterations in the integrity of cardiac muscle microstructure due to the disease. A quantitative analysis is also performed. Another contribution of this chapter is the model-based assessment of the role of the myofiber disarray in modulating the mechanical properties of the myocardium. The results of this study improve our understanding of the structural remodeling mechanisms that are associated with hypetensive left ventricular hypertrophy and their role

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Cardiac Function Estimation from MRI Using a Heart Model and Data Assimilation: Advances and Difficulties

Cited by 37 publications

References 19 publications

Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior

Modeling of cardiac muscle thin films: Pre-stretch, passive and active behavior

Mathematical Modeling of Electrocardiograms: A Numerical Study

Diffusion Tensor Magnetic Resonance Imaging‐Derived Myocardial Fiber Disarray in Hypertensive Left Ventricular Hypertrophy: Visualization, Quantification and the Effect on Mechanical Function

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