Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure

Park, Shuin; Ranjbarvaziri, Sara; Zhao, Peng; Ardehali, Reza

doi:10.1016/j.jacbts.2020.01.016

Cited by 28 publications

(34 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CILP was significantly increased in articular cartilage where osteoarthritis occurred, and as a key regulatory factor, it has been revealed to play an important role in the occurrence and development of osteoarthritis ( 53 ). In recent years, CILP has been regarded as an important indicator protein for myocardial fibrosis, and its expression level indicates the severity of myocardial fibrosis and plays a positive role in clinical diagnosis; decreased levels of CILP are generally considered to indicate severe myocardial fibrosis ( 54 ).…”

Section: Association Between Cartilage Intermediate Layer Protein mentioning

confidence: 99%

Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)

Liu

et al. 2020

Int J Mol Med

View full text Add to dashboard Cite

Intervertebral disc degeneration (IDD), which is caused by multiple factors, affects the health of individuals and contributes to low back pain. The pathology of IDD is complicated, and changes in the extracellular microenvironment play an important role in promoting the process of degeneration. Cartilage intermediate layer protein (CILP) is a matrix protein that resides in the middle of human articular cartilage and is involved in numerous diseases that affect cartilage. However, there is no detailed review of the relationship between CILP and degenerative disc disease. Growing evidence has revealed the presence of CILP in the extracellular microenvironment of intervertebral discs (IVDs) and has suggested that there is a gradual increase in CILP in degenerative discs. Specifically, CILP plays an important role in regulating the metabolism of the extracellular matrix (ECM), an important component of the extracellular microenvironment. CILP can combine with transforming growth factor-β or insulin-like growth factor-1 to regulate the ECM synthesis of IVDs and influence the balance of ECM metabolism, which leads to changes in the extracellular microenvironment to promote the process of IDD. It may be possible to show the correlation of CILP with IDD and to target CILP to interfere with IDD. For this purpose, in the present study, the current knowledge on CILP was summarized and a detailed description of CILP in discs was provided.

show abstract

Section: Association Between Cartilage Intermediate Layer Protein mentioning

confidence: 99%

Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)

Liu

et al. 2020

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…As a novel secreted ECM protein, CILP‐1 has the potential to be a sensitive marker for cardiac fibrosis. Park et al 10 . found that although cardiac CILP‐1 expression was significantly elevated, the level of F‐CILP‐1 in the serum of patients with HF was significantly lower than that in normal subjects.…”

Section: Introductionmentioning

confidence: 99%

“…All three protein variants have been reported to be functional; in particular, F ‐ CILP‐1 and N‐CILP‐1 can directly bind to transforming growth factor‐β1 (TGF‐β1) via the thrombospondin type 1 domain and inhibit its signalling pathway 7,8 . Of note, a growing number of studies suggest that CILP‐1 is expressed in cardiac fibroblasts and exerts anti‐fibrotic effects by interfering with TGF‐β1 signalling 7,9–11 . Myocardial CILP‐1 protein was found to be significantly up‐regulated in animal models of left ventricular pressure overload, 8 acute myocardial infarction (AMI), 11 ischaemia/reperfusion injury, 12 and angiotensin II treatment 9 .…”

Section: Introductionmentioning

confidence: 99%

“… 7 , 8 Of note, a growing number of studies suggest that CILP‐1 is expressed in cardiac fibroblasts and exerts anti‐fibrotic effects by interfering with TGF‐β1 signalling. 7 , 9 , 10 , 11 Myocardial CILP‐1 protein was found to be significantly up‐regulated in animal models of left ventricular pressure overload, 8 acute myocardial infarction (AMI), 11 ischaemia/reperfusion injury, 12 and angiotensin II treatment. 9 Similar results have been observed in human myocardial tissues with AMI and HF.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure

et al. 2021

View full text Add to dashboard Cite

Aims Emerging evidence suggests that cartilage intermediate layer protein 1 (CILP‐1) is associated with myocardial remodelling. However, the prognostic value of circulating CILP‐1 in patients with heart failure (HF) remains to be elucidated. This study aimed to investigate whether circulating CILP‐1 can independently predict the outcome of chronic HF. Methods and results This prospective cohort study included 210 patients with chronic HF and left ventricular ejection fraction <50% between September 2018 and December 2019. The primary endpoint was 1 year all‐cause mortality. During the 1 year follow‐up, 28 patients died. In multivariable Cox proportional hazards regression analysis, higher CILP‐1 levels were independently associated with a higher risk of mortality after adjusting for potential confounding factors. In Kaplan–Meier analysis, patients with CILP‐1 levels above the median had a significantly higher mortality rate than those with CILP‐1 levels below the median (log‐rank P = 0.015). In addition, CILP‐1 significantly improved prognostic prediction over N‐terminal pro‐brain natriuretic peptide by an increase in net reclassification improvement (P = 0.043) and a trend towards an increase in integrated discrimination improvement (P = 0.118). Conclusions Circulating CILP‐1 is a novel independent prognostic predictor in chronic HF.

show abstract

“…Cartilage intermediate layer protein (CILP) encodes cartilage intermediate layer protein and it has been corroborated that the abnormal expression of CILP is associated with a variety of human diseases [ 6 , 7 ]. Recently, Ryan et al have authenticated that the CILP gene polymorphism increases the risk of IDD through a meta-analysis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

MiR-330-5p inhibits intervertebral disk degeneration via targeting CILP

Liu

Chen

2021

J Orthop Surg Res

View full text Add to dashboard Cite

Background Intervertebral disk degeneration (IDD) is caused by nucleus pulposus (NP) degeneration and extracellular matrix (ECM) remodeling and cartilage intermediate layer protein (CILP) expression has been confirmed to be increased in IDD. This study is mainly conducted to clarify the mechanism of CILP in the NP cell degeneration and ECM remodeling in IDD. Methods CILP expression in the degenerated NP tissues and cells is quantified by quantitative real-time PCR and western blot. CILP function is assessed by cell cycle assay, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and flow cytometry, β-galactosidase staining, and the detection of ECM-related molecules aggrecan, collagen type I, collagen type II, MMP-3, and MMP-9 expression is accomplished by qRT-PCR. The potential mechanism is authenticated by dual-luciferase reporter gene assay. Results CILP was increased in the degenerated NP tissues and cells, and the knockdown of CILP promoted the NP cell cycle, increased cell activity, and repressed cell apoptosis and repressed cell senescence and ECM production. Moreover, miR-330-5p targeted the CILP 3′-untranslated region, and miR-330-5p negatively regulated CILP expression. Moreover, the overexpression of miR-330-5p repressed NP cell degeneration and ECM remodeling to relieve IDD by downregulating CILP. Conclusion MiR-330-5p represses NP cell degeneration and ECM remodeling to ameliorate IDD by downregulating CILP.

show abstract

Cardiac Fibrosis Is Associated With Decreased Circulating Levels of Full-Length CILP in Heart Failure

Cited by 28 publications

References 42 publications

Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)

Cartilage intermediate layer protein affects the progression of intervertebral disc degeneration by regulating the extracellular microenvironment (Review)

Prognostic value of cartilage intermediate layer protein 1 in chronic heart failure

MiR-330-5p inhibits intervertebral disk degeneration via targeting CILP

Contact Info

Product

Resources

About