Cardiac fibrosis and miR-433

Oh, Jae Gyun; Hajjar, Roger J.; Park, Woo Jin

doi:10.21037/atm.2016.11.28

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…miR-133 is a negative regulator of fibrosis by downregulation of CTGF [ 161 ]. miR-433 is shown to be a trigger of cardiac fibrosis through inhibition of antizyme inhibitor 1 (AZIN1) and JNK1 in cardiac fibroblasts [ 162 ]. In addition, miR-1, miR-133a, miR-199, and miR-21 increase the expression of TGFβ/Smad3 by downregulation of AZIN1, whereas miR-15, miR-199, miR-21, miR-29, and miR-208 can decrease the expression of JNK1, leading to increase of pSmad3 expression.…”

Section: Noncoding Rnas Involved In Cardiac Fibrosismentioning

confidence: 99%

Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts

2023

Cardiol Ther

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Cardiac fibrosis is closely associated with multiple heart diseases, which are a prominent health issue in the global world. Neurohormones and cytokines play indispensable roles in cardiac fibrosis. Many signaling pathways participate in cardiac fibrosis as well. Cardiac fibrosis is due to impaired degradation of collagen and impaired fibroblast activation, and collagen accumulation results in increasing heart stiffness and inharmonious activity, leading to structure alterations and finally cardiac function decline. Herbal plants have been applied in traditional medicines for thousands of years. Because of their naturality, they have attracted much attention for use in resisting cardiac fibrosis in recent years. This review sheds light on several extracts from herbal plants, which are promising therapeutics for reversing cardiac fibrosis.

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Section: Noncoding Rnas Involved In Cardiac Fibrosismentioning

confidence: 99%

Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts

2023

Cardiol Ther

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CircRNA circ_POSTN promotes the malignancy of glioma by regulating the miR-433-3p/SPARC axis

Hua

Zhang

et al. 2022

Metab Brain Dis

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Role of Circular RNAs in Cardiovascular Disease

Kishore

Garikipati

González

2020

Journal of Cardiovascular Pharmacology

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Circular RNAs (circRNAs) have recently been identified as a new class of long noncoding RNAs with gene regulatory roles. These covalently closed transcripts are generated when the pre-mRNA splicing machinery back splices to join a downstream 5′ splice site to an upstream 3′ splice site. CircRNAs are naturally resistant to degradation by exonucleases and have long half-lives compared with their linear counterpart that potentially could serve as biomarkers for disease. Recent evidence highlights that circRNAs may play an essential role in cardiovascular injury and repair. However, our knowledge of circRNA is still in its infancy with limited direct evidence to suggest that circRNA may play critical roles in the mechanism and treatment of cardiac dysfunction. In this review, we focus on our current understanding of circRNA in the cardiovascular system.

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Cardiac fibrosis and miR-433

Cited by 3 publications

References 28 publications

Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts

Promising Therapeutic Treatments for Cardiac Fibrosis: Herbal Plants and Their Extracts

CircRNA circ_POSTN promotes the malignancy of glioma by regulating the miR-433-3p/SPARC axis

Role of Circular RNAs in Cardiovascular Disease

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