Cardiac diseases in maintenance hemodialysis patients: Results of the HEMO Study

Cheung, Alfred K.; Sarnak, Mark J.; Gao, Yan; Berkoben, Michael; Heyka, Robert; Kaufman, Allen; Lewis, Julia B.; Rocco, Michael V.; Toto, Robert D.; Windus, David W.; Ornt, Daniel B.; Levey, Andrew S.

doi:10.1111/j.1523-1755.2004.00657.x

Cited by 478 publications

(396 citation statements)

References 20 publications

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“…Zoccali et al 7 in a study of 254 hemodialysis patients, Rakhit et al 35 in a study that included 176 patients with CKD stages 4 and 5 on conservative treatment or dialysis, and Cheung et al 22 in the HEMO multicenter study, described a similar result in the final model of Cox multivariate analysis.…”

Section: Siqueira Et Al Doppler Echocardiogram In Hemodialysis Patientssupporting

confidence: 50%

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Parâmetros ecocardiográficos como preditores de eventos cardiovasculares em pacientes em hemodiálise

Siqueira¹,

Ferreira²,

Júnior³

et al. 2012

Arq. Bras. Cardiol.

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Section: Siqueira Et Al Doppler Echocardiogram In Hemodialysis Patientssupporting

confidence: 50%

“…HEMO and AURORA studies, showed rates of less than 50% of mortality due to heart disease in the dialysis population 22,23 . These results confirm that CVD remain the leading cause of morbidity and mortality in hemodialysis patients.…”

Section: Survival Function Censoredmentioning

confidence: 99%

Parâmetros ecocardiográficos como preditores de eventos cardiovasculares em pacientes em hemodiálise

Siqueira¹,

Ferreira²,

Júnior³

et al. 2012

Arq. Bras. Cardiol.

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“…The protocols used for the collection and validation of outcome data have been previously described in detail (12)(13)(14). The primary outcome of the HEMO Study was all-cause mortality.…”

Section: Follow-up and Outcomesmentioning

confidence: 99%

Association between Serum β2-Microglobulin Level and Infectious Mortality in Hemodialysis Patients

Cheung

Greene

Leypoldt

et al. 2008

Clinical Journal of the American Society of Nephrology

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Background and objectives: Secondary analysis of the Hemodialysis Study showed that serum ␤ 2 -microglobulin levels predicted all-cause mortality and that high-flux dialysis was associated with decreased cardiac deaths in hemodialysis patients. This study examined the association of serum ␤ 2 -microglobulin levels and dialyzer ␤ 2 -microglobulin kinetics with the two most common causes of deaths: Cardiac and infectious diseases.Cox regression analyses were performed to relate cardiac or infectious deaths to cumulative mean follow-up predialysis serum ␤ 2 -microglobulin levels while controlling for baseline demographics, comorbidity, residual kidney function, and dialysis-related variables.Results: The cohort of 1813 patients experienced 180 infectious deaths and 315 cardiac deaths. The adjusted hazard ratio for infectious death was 1.21 (95% confidence interval 1.07 to 1.37) per 10-mg/L increase in ␤ 2 -microglobulin. This association was independent of the prestudy years on dialysis. In contrast, the association between serum ␤ 2 -microglobulin level and cardiac death was not statistically significant. In similar regression models, higher cumulative mean Kt/V of ␤ 2 -microglobulin was not significantly associated with either infectious or cardiac mortality in the full cohort but exhibited trends suggesting an association with lower infectious mortality (relative risk 0.93; 95% confidence interval 0.86 to 1.01, for each 0.1-U increase in ␤ 2 -microglobulin Kt/V) and lower cardiac mortality (relative risk 0.93; 95% confidence interval 0.87 to 1.00) in the subgroup with >3.7 prestudy years of dialysis.Conclusions: These results generally support the notion that middle molecules are associated with systemic toxicity and that their accumulation predisposes dialysis patients to infectious deaths, independent of the duration of maintenance dialysis.

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“…Acute myocardial injury is a leading cause of hospitalisation and death in the dialysis population (9.8-16 per 100-patient years), and cardiac troponins are among the most frequently requested tests in this group [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Biological variation of high sensitivity cardiac troponin-T in stable dialysis patients: implications for clinical practice

Fahim¹,

Hayen

Horvath³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Cardiac diseases in maintenance hemodialysis patients: Results of the HEMO Study

Cited by 478 publications

References 20 publications

Parâmetros ecocardiográficos como preditores de eventos cardiovasculares em pacientes em hemodiálise

Parâmetros ecocardiográficos como preditores de eventos cardiovasculares em pacientes em hemodiálise

Association between Serum β2-Microglobulin Level and Infectious Mortality in Hemodialysis Patients

Biological variation of high sensitivity cardiac troponin-T in stable dialysis patients: implications for clinical practice

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