Cardiac Dimensions and Functional Parameters in Nigerian Children with Homozygous Sickle Cell Anaemia Using Echocardiography

Bamigboye-Taiwo, O T; Okeniyi, John A.O.; Omokhodion, Samuel; Adeodu, O O; Elusiyan, Jerome B

doi:10.4172/2155-9880.1000368

Cited by 3 publications

(8 citation statements)

References 24 publications

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“…In this study, the left atrial and left ventricular internal dimensions, wall thickness and LV mass were significantly increased in SCD patients, though LV ejection fraction was similar in both groups. This finding is in keeping with findings from previous studies [13] enlargement and hypertrophy is compensatory mechanisms for the long standing volume overload. These cardiac changes are needed in patients with chronic anaemia to increase the cardiac output, with little increase in heart rate.…”

Section: Discussionsupporting

confidence: 93%

Topic: Echocardiographic Evaluation of Left Ventricular Systolic and Diastolic Function in Nigerians with Sickle Cell Disease

Saidu¹,

Kabir²,

Yau³

et al. 2018

OALib

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Introduction: Sickle cell disease (SCD) is chronic, inherited haemoglobin disorder, associated with chronic tissue ischemia which may adversely affect any organ system. Chronic anaemia in SCD results in cardiac chamber dilatation with compensatory increase in left ventricular mass and varying degree of diastolic dysfunction that has been a strong independent predictor of mortality in patients with SCD. There is paucity of echocardiographic studies on adults Nigerians with SCD. This study therefore, aimed to assess left ventricular systolic and diastolic function among sickle cell disease patients in Kano State, NorthWestern Nigeria. Methods: The study was cross-sectional and comparative conducted at the SCD clinic and Medical/outpatient (MOP) clinic of Murtala Muhammad Specialist Hospital (MMSH), on eligible patients aged 13 years and above. One hundred patients with SCD (HbSS) were recruited as the study group while 100 non SCD (HbAA) patients, matched for age and sex served as controls. Left and right atrial and ventricular dimensions, left ventricular (LV) wall thickness, LV mass index and LV contractility variables were obtained. Parameters of LV diastolic function were also evaluated. Results: There were increases in the left atrial and left ventricular dimensions, left ventricular volumes and left ventricular mass (LVM) of the SCD patients. LV ejection fraction was equivalent, though there was evidence of left ventricular diastolic dysfunction in up to 36%. Conclusion: Left ventricular diastolic dysfunction may complicate cases adults with SCD.

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Section: Discussionsupporting

confidence: 93%

Topic: Echocardiographic Evaluation of Left Ventricular Systolic and Diastolic Function in Nigerians with Sickle Cell Disease

Saidu¹,

Kabir²,

Yau³

et al. 2018

OALib

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“…The inter-and intra-observer variability was calculated as (mean percentage errors) 13 . All measurements were compared with that of the standard population by calculating their z-scores [16][17][18] .…”

Section: Methods Of Assessing Cardiac Chambersmentioning

confidence: 99%

“…This study was carried out at the out-patient clinic of UNTH, Ituku-Ozalla, Enugu among children who were between 3 years and 18 years. This is because confounders such as increase biventricular pressure which is seen in children with sickle cell anaemia below the age of three years will affect the results [15][16][17] .…”

Section: Study Area/populationmentioning

confidence: 99%

“…This is best done by correlating this measurement with body surface area. Previous studies [9][10][11] had reported normal left ventricular (LV) function in patients with severe chronic anaemia, while others [12][13][14] document varying degrees of left ventricular (LV) dysfunction with significantly decreased fractional shortening or abnormal systolic time [15][16] . To date, no consensus exists as to whether myocardial contractility is inherently affected by long-standing severe anaemia or is simply altered by chronic anaemia 17,18 .…”

Section: Introductionmentioning

confidence: 99%

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Left ventricular function and cardiac valvar annular dimensions among children with sickle cell anemia compared to those with hemoglobin AA type in Enugu, Nigeria

Chinawa

Ossai

et al. 2021

Mal. Med. J

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BackgroundEnumerating the relationship between cardiac structures, function and chamber sizes in children with sickle cell anemia would help in delineating some cardiovascular abnormalities which will aid the Pediatric cardiologist and the cardiac surgeons in a number of decision-making situations.ObjectivesThe objectives of this study are to assess the dimension of cardiac structures and left ventricular function in children with sickle cell anemia in steady state and controls using echocardiography.MethodsA cross-sectional prospective study that assessed cardiac structures and left ventricular function among fifty-one children with sickle cell anemia (HBSS) and compared with fifty children with HB AA type serving as controls.ResultsA significant high proportion of children with sickle cell anemia had abnormal Valvar dimension and left ventricular function above two standard deviations (2-SD) from the mean of the standard population compared to the control group, showing a statistically significant difference (χ2 = 10.42, p= 0.001). All the mean annular valves diameter, left ventricular internal dimension in systole and diastole, inter-sinus distance diameter and sinu-tubular junction diameter are higher in children with sickle cell anemia than controls and this is statistically significant. (p<0.005). ConclusionThis result shows that children with sickle cell anemia have increased valvar size diameter compared with those with normal hemoglobin type. A significantly higher proportion of respondents in type SS group had abnormal left ventricular systolic and diastolic dysfunction when compared with those in type AA group

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“…[2] The clinical manifestations of SCA are protean with multiorgan effects, including cardiovascular complications, which are recognized as signi cant contributors to morbidity in these children. [3,4] The structural integrity and contractile function of the left ventricle in children with SCA have received little research attention, and con icting ndings have been reported; [4][5][6][7] however, Rees et al [8] reported a signi cantly reduced left ventricular ejection fraction (LVEF) in children with SCA compared with controls in the USA, Chung et al [9] in Jamaica, and Bamigboye-Taiwo et al [10] in Nigeria found no signi cant difference between the two groups with respect to LVEF. Furthermore, the relationship between haemoglobin and foetal haemoglobin levels and left ventricular systolic function and geometric patterns in paediatric SCA patients has remained largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

Left Ventricular Geometric Patterns and Systolic Myocardial Performance in Nigerian Children with Homozygous Sickle Cell Anaemia

Peter,

Asani,

Abdullahi

et al. 2024

Preprint

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Background: Cardiac complications contribute significantly to morbidity in children with sickle cell anaemia (SCA). Little is known about the geometry and contractile function of the left ventricle (LV) of affected children in sub-Saharan Africa, which has the greatest burden of thisdisease. Objective: To compare the LV systolic function of children with SCA in the steady state with that of matched haemoglobin AA controls. Methods: Clinical, laboratory and LV M-mode echocardiographic parameters of 120 steady-state SCA patients aged 3-14 years were compared with those of matched Hb AA controls. Univariate and multivariate analyses were performed using SPSS software, version 22 (IBM, Armonk, NY, USA). Results: The median ejection fraction of 62.00 (IQR=55.0-67.0) for the subjects was significantly less than that of 68.00 (IQR=65.8-73.0) for the controls (p< 0.001) and correlated negatively with age (ρ=-0.25, p= 0.006), BSA (ρ=-0.24, p= 0.008), systolic BP (ρ=-0.23, p=0.022), and diastolic BP (ρ=-0.31, p=0.002). Left ventricular systolic dysfunction (LVSD) was present in 27% of the SCA patients but only in 1% of the controls (χ² = 26.5, p< 0.001). The odds of having LVSD decreased by 0.9 for every 1% increase in HbF level (CI= 0.82-0.99, p= 0.03). Abnormal LV geometry, detected in 52% of the subjects, was associated with the presence of LVSD (Fisher’s exact test, p< 0.001). The odds of having abnormal LV geometry decreased by 0.5 for every 1 g increase in Hb level (CI=0.27-0.87, p=0.02). Conclusions: LVSD is more common in SCA patients than in controls and is less likely to occur in patients with higher HbF levels. Approximately one in every two children with SCA have abnormal LV geometry, which is less likely to occur at higher Hb levels.

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Cardiac Dimensions and Functional Parameters in Nigerian Children with Homozygous Sickle Cell Anaemia Using Echocardiography

Abstract: Background: Sickle cell anaemia (SCA) is the most common and burdensome inherited disease affecting children in Africa. Nonetheless, there remains a paucity of literature from Nigeria about its effects on cardiac dimensions and functioning in children.

Cited by 3 publications

References 24 publications

Topic: Echocardiographic Evaluation of Left Ventricular Systolic and Diastolic Function in Nigerians with Sickle Cell Disease

Topic: Echocardiographic Evaluation of Left Ventricular Systolic and Diastolic Function in Nigerians with Sickle Cell Disease

Left ventricular function and cardiac valvar annular dimensions among children with sickle cell anemia compared to those with hemoglobin AA type in Enugu, Nigeria

Left Ventricular Geometric Patterns and Systolic Myocardial Performance in Nigerian Children with Homozygous Sickle Cell Anaemia

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