Cardiac device-related infective endocarditis in the Czech Republic: Prospective data from the ESC EORP EURO-ENDO registry

Abstract

Aim. Understanding cardiac electronic device infective endocarditis epidemiology is essential for the management of this serious complication. Only monocentric and limited data have been published regarding patients in the Czech republic so far. The aim of this study was to describe the current profile, microbiology and clinical characteristics of this population. Patients and Methods. National data from the prospective ESC-EORP EURO-ENDO registry were collected. 57 consecutive patients with a diagnosis of cardiac device-related infective endocarditis (CDRIE) from 11 Czech centres were included. Results. Staphylococcus spp. was responsible for 43.9% of isolates, whereas Culture negative endocarditis was documented in 26.3% episodes. The most frequent complications under therapy were acute renal failure (17.5%), septic shock and heart failure (both 10.5%). Extraction of device was performed in 75.4% of all patients, and the 1-year mortality was 22.5%. Conclusions. The high proportion of culture-negative endocarditis is alarming and warrants further investigation. Cardiac device related infective endocarditis is a serious complication with a high 1-year mortality in a highly polymorbid spectrum of patients.

The Role of the 18F-FDG PET/CT in the Management of Patients Suspected of Cardiac Implantable Electronic Devices’ Infection

“…The hospitalization departments from which requests for evaluation were received were the following: hospital cardiology ( Blood cultures were requested and performed for all patients; they were positive in 18/48 (37.5%) patients and negative in the remaining 30/48 (62.5%). The bacteria isolated from the cultures, responsible for the bacteremia, were: Staphylococcus aureus in 5/18 (27.8%); Staphylococcus epidermidis in 4/18 (22.2%); Staphylococcus hominis in 3/18 (16.7%); Corynebacterium in 2/18 (11.1%); Serratia marcescens in 1/18 (5.6%); Pseudomonas aeruginosa in 1/18 (5.6%); Achromobacter Xyloxosidans in 1/18 (5.6%); Klebsiella in 1/18 (5.6%); Enterococcus faecalis in 1/18 (5.6%); Enterococcus faecium in 1/18 (5.6%); Enterococcus gallinarum in 1/18 (5.6%); Enterobacter cloacae in 1/18 (5.6%) (Figure 2) [2]. In 4/18 (22.2%) patients the bacteremia was found to be supported by two species simultaneously.…”

“…In recent decades, scientific-technological development has led to a great improvement in Cardiac Implantable Electronic Devices (CIEDs) [1][2][3]. At the same time, the epidemiological profile of the population has changed, with a lengthening of the average lifetime, a parallel increase in the number of patients suffering from numerous comorbidities or immune-compromised diseses, and a greater incidence of age-related cardiovascular events [1][2][3]. Therefore, the indication for CIEDs' implantation has significantly increased, as they are fundamental devices for numerous cardiac diseases that can compromise patients' lives [4][5][6].…”