Cardiac damage following renal ischemia reperfusion injury increased with excessive consumption of high fat diet but enhanced the cardiac resistance to reperfusion stress in rat

Does cardiac impairment develop in ischemic renal surgery in rats depending on the reperfusion time?

“…A study conducted in our lab revealed histological changes in the kidney following ischemia, leading to AKI, characterized by loss of brush border in proximal convoluted tubule (PCT), inflammatory cell infiltration, and sloughing of epithelial cells, particularly notable in rats fed with a high-fat diet [ 35 ]. We also noted that rats fed a high-fat diet for 16 weeks showed increased sensitivity of the heart to renal ischemia-reperfusion-induced injury [ 36 ]. It is well established that the repopulation of damaged cells in nephrons relies on surviving tubular cells with stem cell characteristics, which may themselves be affected by ischemic insult [ 37 ].…”