Cardiac contractility after transplantation of autologous mononuclear bone marrow cells in patients with myocardial infarction

Abstract

Autologous bone marrow mononuclear cells were transplanted by intracoronary infusion to patients with myocardial infarction after recovery of coronary perfusion. Controls received traditional therapy alone. Echocardiography was carried out before and 3 and 6 months after cell therapy. Cell transplantation did not appreciably improved left-ventricular contractility in comparison with the control group. In none patient cell therapy provoked malignant ventricular arrhythmias. Intracoronary infusion of bone marrow mononuclear cells in patients with myocardial infarction did not improve cardiac contractility and did not aggravate the course of the disease.

Cells and Materials for Cardiac Repair and Regeneration

“…As an example, already in 2004, Heeschen et al noted that bone marrow mononuclear cells (BMMNCs) isolated from patients with ischemic chronic myocardiopathy, irrespective of their similar hematopoietic stem cell content compared to healthy controls, had a significantly reduced neovascularization capacity in a mouse hind limb assay [49]. Furthermore, in a 2006 clinical study in which BMMNCs were injected by an intracoronary route into patients with cardiac ischemia, there was no evidence of improvements in contractility [50].…”

Hypoxic Preconditioning of Stem Cells as a New Approach to Increase the Efficacy of Cell Therapy for Myocardial Infarction

“…Следовательно, были все основания ожидать положительный эффект клеточной терапии на сократимость ЛЖ и коронарную перфузию. Однако по-вторное обследование больных через 6 месяцев после ИМ не выявило ни достоверного увеличения фракции выбро-са ЛЖ (ФВ ЛЖ), ни достоверного уменьшения величины стабильного дефекта перфузии [36,38,39]. Согласно данным других исследователей, пересадка аутологичных МККМ далеко не у всех обследованных пациентов оказы-вает положительный эффект на сократимость миокарда [33,35,40,41].…”

Bone marrow stem cells transplanted to the testis of sterile mice do not differentiate into spermatogonial stem cells and have no protective effect on fertility

“…However, when BMSCs were injected in the testis, only a few GFP þ cells were observed in the lumen of the tubules 4 months after transplantation. For BMSC transplantation, the mononuclear fraction of the bone marrow was selected, containing hematopoietic stem cells and mesenchymal stem cells (16). The GFP þ cells observed were not attached to the basement membrane and therefore are unlikely to be spermatogonia.…”