Cardiac conduction in patients with hypercalcaemia due to primary hyperparathyroidism

Rosenqvist, Mårten; Nordenström, Jörgen; Andersson, Matilda; Edhag, O

doi:10.1111/j.1365-2265.1992.tb02279.x

Cited by 46 publications

(26 citation statements)

References 17 publications

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“…PTHT is reported to be associated with hypertension [15,16], arrhythmia [17], and structural and functional alterations in the heart and vascular wall [18,19]. An increased prevalence of cardiac structural abnormalities such as left ventricular hypertrophy and valvular and myocardial calcification has been observed [18,20,21].…”

Section: Introductionmentioning

confidence: 96%

Circulating leptin and adiponectin levels in patients with primary hyperparathyroidism

Delfini¹,

Petramala²,

Caliumi³

et al. 2007

Metabolism

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Section: Introductionmentioning

confidence: 96%

Circulating leptin and adiponectin levels in patients with primary hyperparathyroidism

Delfini¹,

Petramala²,

Caliumi³

et al. 2007

Metabolism

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“…Again, data are limited in asymptomatic patients. A small study in patients with more moderate hypercalcemia ͓mean calcium, (11.4 mg/dl) 2.85 mmol/liter͔ confirmed an increase in QT interval after parathyroidectomy but found no increased prevalence of supraventricular or ventricular arrhythmias or highgrade atrioventricular block (31). QT shortening was not observed in the small study of Barletta et al (32) ͓11.5 mg/dl (2.88 mmol/liter)͔, but only 14 patients were studied.…”

Section: Cardiac Conduction Abnormalities and Arrhythmiamentioning

confidence: 77%

Presentation of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop

Eastell

Arnold

Brandi

et al. 2009

The Journal of Clinical Endocrinology &Amp; Metabolism

445

206

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1) Data on the extent and nature of cardiovascular involvement in those with mild disease are too limited to provide a complete picture. 2) Patients with mild PHPT have neuropsychological complaints. Although some symptoms may improve with surgery, available data remain inconsistent on their precise nature and reversibility. 3) Surgery leads to long-term gains in spine, hip, and radius bone mineral density (BMD). Because some patients have early disease progression and others lose BMD after 8-10 yr, regular monitoring (serum calcium and three-site BMD) is essential in those followed without surgery. Patients may present with normocalcemic PHPT (normal serum calcium with elevated PTH concentrations; no secondary cause for hyperparathyroidism). Data on the incidence and natural history of this phenotype are limited. 4) In the absence of kidney stones, data do not support the use of marked hypercalciuria (>10 mmol/d or 400 mg/d) as an indication for surgery for patients. 5) Patients with bone density T-score -2.5 or less at the lumbar spine, hip, or distal one third radius should have surgery.

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“…Similarly, a recent study failed to demonstrate any effect of moderate hypercalcemia on cardiac conduction 7 .…”

Section: Introductionmentioning

confidence: 91%

Sick sinus syndrome secondary to primary hyperparathyroidism

et al. 2016

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SUMMARYThe effects of hypercalcemia on the heart and the resulting alternations of the electrocardiogram have been well established. However, there are only limited number of reports in the literature on primary hyperparathyroidism leading to clinically significant arrhythmias. We present a patient who was diagnosed with symptomatic sick sinus syndrome in the setting of moderate hypercalc emia secondary to primary hyperparathyroidism in this case report. After the surgical operation for primary hyperparathyroidism, serum calcium level returned to normal range and patient's co mplaints and arrhytmic findings recovered. The patient was asymptoma tic for the following 13 years.

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Cardiac conduction in patients with hypercalcaemia due to primary hyperparathyroidism

Abstract: It is concluded that moderate hypercalcaemia, in spite of causing a shortening of the repolarization phase (QT-interval), has no clinically significant effect on cardiac conduction.

Cited by 46 publications

References 17 publications

Circulating leptin and adiponectin levels in patients with primary hyperparathyroidism

Circulating leptin and adiponectin levels in patients with primary hyperparathyroidism

Presentation of Asymptomatic Primary Hyperparathyroidism: Proceedings of the Third International Workshop

Sick sinus syndrome secondary to primary hyperparathyroidism

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