Cardiac botryomycosis: an autopsy report

Abstract

Visceral botryomycosis is rare, and documented sites are lung, brain, kidney, liver and prostate. This report describes a rare autopsy case of disseminated visceral botryomycosis, with bulky, grape-like botryomycotic vegetations in the heart, and similar abscesses in the lungs and bone marrow. This is the first such report in the literature to the best of our knowledge.

Incidental Renal Botryomycosis in a Nonfunctioning Kidney

“…Gram stain identifies the causative bacterial agent in botryomycosis, which is confirmed by culture. These bacterial colonies are usually negative for Grocott-Gomori silver stain [6–8]. The present case revealed Gram negative bacilli.…”

“…Visceral involvement is unusual [2, 3]. The lung is the most common viscera involved; however botryomycosis of the liver, trachea, heart, bowel, and brain have also been documented [6]. Rare cases of renal botryomycosis have been reported in the literature (Table 1).…”

“…Both these lesions demonstrate Splendore-Hoepple phenomenon characterized by deposition of periodic acid-Schiff positive amorphous eosinophilic material around bacterial colonies [6]. Gram and Grocott-Gomori silver stain help is distinguishing these two entities.…”

Teenage male patient with new onset B‐cell acute lymphoblastic leukemia and painful indurated pink‐violet papules on the trunk and extremities

“…Histopathologically, botryomycosis demonstrates eosinophilic material surrounding densely packed microorganisms (the SplendoreHoeppli phenomenon) 4 . Staphylococcus aureus , Escherichia coli , and Pseudomonas aeruginosa are the most frequent causative organisms 4 . Actinomycosis and mycetomas may also display this histologic phenomenon 4 …”

“…4 Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa are the most frequent causative organisms. 4 Actinomycosis and mycetomas may also display this histologic phenomenon. 4 This reaction may occur with parasites (schistosomiasis, larva migrans), cutaneous flora (Malassezia), and noninfectious etiologies including hypereosinophilic syndrome.…”