Cardiac Biomarkers in End-Stage Renal Disease

Jacobs, Lotte; Mingels, Alma M.A.; Dieijen-Visser, Marja P. van

doi:10.5772/26524

Cited by 1 publication

(1 citation statement)

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“…Despite extensive evidence supporting the association of elevated cTnI levels with cardiac and all-cause mortality in asymptomatic hemodialysis patients, H-FABP may prove to be a more reliable biomarker in these patients. 14,15 Conceivably, H-FABP may detect subclinical myocardium injury prior to the onset of cTnI elevation in patients with ESRD. In addition, vWF is a protein that promotes the attachment of platelets to areas of injury in blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Immunoenzymatic and Biochip Array Profiling of the Biomarkers of Inflammation and Hemostatic Activation Processes in ESRD

Richards

Bansal

Iqbal

et al. 2015

Clin Appl Thromb Hemost

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There is a high incidence of mortality due to cardiovascular events seen in patients with end-stage renal disease (ESRD) undergoing hemodialysis. Through utilization of biochip microarrays and enzyme-linked immunosorbent assay methods, we assessed various cardiac, inflammatory, thrombotic, and cerebral biomarkers to determine their roles in the hemostatic activation or inflammatory processes in ESRD. In this study, 72 patients on maintenance hemodialysis were recruited and 53 normal healthy male and female adults volunteers. Blood samples from patients with ESRD were drawn prior to maintenance hemodialysis. Of the 15 statistically significant biomarkers, 10 were elevated in the ESRD group, most notably soluble tumor necrosis factor receptor 1, heart-type fatty acid binding protein, and von Willebrand factor activity. These results are consistent with previously reported studies proposing ESRD represents a poly-pathologic process with the activation of hemostatic and inflammatory processes, which contribute to the significant sequelae of cardiovascular disease seen in these patients.

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Section: Discussionmentioning

confidence: 99%