Cardiac biochemical monitoring for the detection of acute myocardial ischemia

Pöling, Jochen; Rees, W.; Klaus, Stephan; Bahlmann, Ludger; Gumniah, Mahesh; Ziaukas, V.; Warnecke, H.

doi:10.1007/s00134-006-0074-0

Cited by 4 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The association/connection/correlation between increased myocardial lactate levels – determined by microdialysis – and reduced myocardial performance with difficult weaning from CPB during CABG suggests that this technique may be an adjunct for stratifying treatment during these interventions (14). In critical care medicine, the myocardial/systemic glucose ratio seems to be a promising tool for detecting metabolic disorders on the level of the vulnerable myocardium in the post‐operative condition/phase (15).…”

mentioning

confidence: 99%

Myocardial metabolic monitoring with the microdialysis technique during and after open heart surgery

Pöling

Rees

Klaus

et al. 2007

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

mentioning

confidence: 99%

Myocardial metabolic monitoring with the microdialysis technique during and after open heart surgery

Pöling

Rees

Klaus

et al. 2007

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

“…The association between increased myocardial lactate levels – determined by microdialysis – and reduced myocardial performance with difficult weaning from cardiopulmonary bypass (CPB) during CABG suggests that this technique may be an adjunct for stratifying treatment during these interventions. In critical care medicine, the myocardial/systemic glucose ratio may be a promising tool to detect postoperative metabolic disorders in vulnerable myocardium extremely fast and with high sensitivity [18]. …”

Section: Introductionmentioning

confidence: 99%

Functional Recovery of Chronic Ischemic Myocardium after Surgical Revascularization Correlates with Magnitude of Oxidative Metabolism

Pöling

Rees

Klaus³

et al. 2007

Cardiology

Self Cite

View full text Add to dashboard Cite

Background: The purpose of this study was to validate myocardial microdialysis measurements in patients after myocardial infarction with or without associated postoperative functional recovery in order to develop a highly sensitive tool for real-time in vivo detection of microcellular disorder during cardiac operations. Methods: In 20 patients undergoing coronary artery bypass grafting, microdialysis catheters were implanted into scar or hibernating segments detected by means of magnetic resonance imaging, and into a vital area of the right ventricle (control). Myocardial glucose, lactate and pyruvate were analyzed perioperatively. Myocardial ethanol washout was measured as a sign of recovered local blood flow. Results: After surgical revascularization, improvement of wall motion was found in all hibernating segments compared to the scar segments paralleling an increased glucose delivery to the tissue and increased myocardial tissue flow. The myocardial glucose/lactate ratio and pyruvate also showed significantly higher values. Microdialytic measurements of the viable segments were comparable with those of the right ventricle. Conclusions: Our results indicate that microdialysis measurements parallel magnetic resonance imaging findings in patients with revascularization of chronic ischemic myocardium with dyskinetic segments. The metabolism of those segments is characterized by a significantly increased tissue flow, an increased utilization of glucose and a better oxidative nutrition.

show abstract