Cardiac autotransplantation and ex vivo surgical repair of giant left atrium: a case presentation

Mitrev, Zan; Klincheva, Milka; Anguseva, Tanja; Zdravkovski, Igor; Rosalia, Rodney Alexander

doi:10.1186/s12872-018-0966-2

Cited by 3 publications

(1 citation statement)

References 36 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exploiting the improved access routes to critically located tumors, various case studies in cardiac surgery have reported successful ex vivo resections of cardiac sarcoma ( 200 ), complex atrial myofibroblastic tumors ( 201 ), and giant large atria following chronic mitral valve disease on an ex vivo beating heart ( 202 ). Moreover, single centers also have reported on larger case numbers of cardiac autotransplantation with ex vivo tumor resection for malignant complex primary left heart tumors ( 203 ) ( Figure 2G ).…”

Section: Potential Of Evmp Beyond Ordinary Graft Preservationmentioning

confidence: 99%

Pushing the boundaries of innovation: the potential of ex vivo organ perfusion from an interdisciplinary point of view

Iske,

Schroeter,

Knoedler

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Ex vivo machine perfusion (EVMP) is an emerging technique for preserving explanted solid organs with primary application in allogeneic organ transplantation. EVMP has been established as an alternative to the standard of care static-cold preservation, allowing for prolonged preservation and real-time monitoring of organ quality while reducing/preventing ischemia–reperfusion injury. Moreover, it has paved the way to involve expanded criteria donors, e.g., after circulatory death, thus expanding the donor organ pool. Ongoing improvements in EVMP protocols, especially expanding the duration of preservation, paved the way for its broader application, in particular for reconditioning and modification of diseased organs and tumor and infection therapies and regenerative approaches. Moreover, implementing EVMP for in vivo-like preclinical studies improving disease modeling raises significant interest, while providing an ideal interface for bioengineering and genetic manipulation. These approaches can be applied not only in an allogeneic and xenogeneic transplant setting but also in an autologous setting, where patients can be on temporary organ support while the diseased organs are treated ex vivo, followed by reimplantation of the cured organ. This review provides a comprehensive overview of the differences and similarities in abdominal (kidney and liver) and thoracic (lung and heart) EVMP, focusing on the organ-specific components and preservation techniques, specifically on the composition of perfusion solutions and their supplements and perfusion temperatures and flow conditions. Novel treatment opportunities beyond organ transplantation and limitations of abdominal and thoracic EVMP are delineated to identify complementary interdisciplinary approaches for the application and development of this technique.

show abstract

Section: Potential Of Evmp Beyond Ordinary Graft Preservationmentioning

confidence: 99%

Pushing the boundaries of innovation: the potential of ex vivo organ perfusion from an interdisciplinary point of view

Iske,

Schroeter,

Knoedler

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

Clinical Effects of Surgical Left Atrial Reduction and Concomitant Mitral Valve Replacement in Patients with Giant Left Atrium

Song

Wang

Bao

et al. 2023

Braz J Cardiovasc Surg

View full text Add to dashboard Cite

Introduction A giant left atrium may cause respiratory dysfunction and hemodynamic disturbance postoperatively. This retrospective study aimed to evaluate clinical effects of surgical left atrial reduction in concomitant cardiac valves operations. Methods One hundred and thirty-five patients with heart valve diseases and giant left atriums from January 2004 to July 2021 were enrolled into this research. They were divided into the folded group (n=63) and the unfolded group (n=72). Patients in the folded group had undergone cardiac valve operations concomitantly with left atrial reductions. The perioperative characteristics were compared between both groups, and subgroup analysis was performed. Results There were five deaths in the folded group and 25 deaths in the unfolded group (P<0.001). Complications including pneumonia, sepsis, multiple organs dysfunction syndrome, low cardiac output syndrome, and the use of continuous renal replacement therapy were significantly fewer in the folded group. The receiver operating characteristic curve of left atrial max. diameter predicting mortality was significant (area under the curve=0.878, P=0.005), and the cutoff point was 96.5 mm. The stratified analysis for sex showed that more female patients died in the unfolded group. Logistic regression for mortality showed that the left atrium unfolded, left atrial max. diameter, cardiopulmonary bypass time, and mechanical ventilation time increased the risk of death. Conclusion Surgical left atrial reduction concomitantly with valves replacement could decrease mortality and was safe and effective in giant left atrium patients.

show abstract

Three-valve reconstruction with prosthetic repair of the ascending portion of the aorta in elderly patients

Комаров¹,

Puzenko²,

Isaev³

et al. 2020

Angiol Sosud Khir

View full text Add to dashboard Cite

Cardiac autotransplantation and ex vivo surgical repair of giant left atrium: a case presentation

Cited by 3 publications

References 36 publications

Pushing the boundaries of innovation: the potential of ex vivo organ perfusion from an interdisciplinary point of view

Pushing the boundaries of innovation: the potential of ex vivo organ perfusion from an interdisciplinary point of view

Clinical Effects of Surgical Left Atrial Reduction and Concomitant Mitral Valve Replacement in Patients with Giant Left Atrium

Three-valve reconstruction with prosthetic repair of the ascending portion of the aorta in elderly patients

Contact Info

Product

Resources

About