Cardiac Autonomic Regulation Is Disturbed in Children with Euthyroid Hashimoto Thyroiditis

Kilic, Ayhan; Gülgün, Mustafa; Tascilar, Mehmet Emre; Sarı, Erkan; Yokuşoğlu, Mehmet

doi:10.1620/tjem.226.191

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Highly variable heart rates are a sign of good autonomic control. [4][5][6] The HRV is assessed by time and frequencydomain variables. There is a general agreement that the high-frequency band (HF) reflects parasympathetic activity and low-frequency band (LF) reflects both parasympathetic and sympathetic activity.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical studies have shown that impaired HRV correlates with an increased risk of cardiovascular mortality. 4,5 It is important to assess the autonomic functions in SLE as some studies proposed that the autonomic fluctuations might predispose to ventricular arrhythmias and circulatory dysfunction. 6,7 Both sympathetic and parasympathetic pathways are associated with acute and chronic inflammation and autonomic dysfunction in SLE.…”

mentioning

confidence: 99%

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Heart rate variability in juvenile systemic lupus erythematosus patients

Başaran¹,

Çetin²,

Aydın³

et al. 2019

Turk J Pediatr

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Although neurological involvement has been well recognized in patients with systemic lupus erythematosus (SLE), autonomic nervous system (ANS) involvement has rarely been studied, and has shown conflicting results. The aim of this study was to evaluate the ANS functions by using heart rate variability (HRV) in juvenile patients with SLE. Sixteen juvenile-onset SLE patients and 16 healthy controls were enrolled in the study. All participants underwent 24-hour Holter electrocardiogram monitoring and HRV indices were assessed. The SLE disease activity index (SLEDAI) score was used to assess the disease activity. We analyzed the correlation between disease duration, the SLEDAI score, and the HRV domains. Overall HRV was diminished in patients with SLE compared to controls. There were negative correlations between day and night RMSSD (root-mean-square of the successive normal sinus NN interval differences) and PNN50 (percentage of successive normal sinus NN intervals >50 ms) values, and SLEDAI (r=-0.588 p=0.017; r=-0.607 p= 0.013; r=-0.498 p=0.049; r=-0.597 p=0.015, respectively). There were positive correlations between both day and night LF/HF values and SLEDAI (r=0.766 p=0.001; r=0.635 p=0.008, respectively). The results suggest that autonomic dysfunction exists in juvenile patients with SLE. As these children are at increased risk for cardiovascular disease, they need to be assessed for the development of autonomic dysfunction.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Heart rate variability in juvenile systemic lupus erythematosus patients

Başaran¹,

Çetin²,

Aydın³

et al. 2019

Turk J Pediatr

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“…Thyroid disease is a common comorbidity of diabetes and has in itself been reported to lower HRV (Celik et al, 2011; Kilic et al, 2012). This renders it as a possible confounder when studying CAN.…”

Section: Discussionmentioning

confidence: 99%

“…Previously described factors of possible importance for the HRV analysis other than psychosocial stress are as follows: hypoglycemia (Jaiswal et al, 2014; Koivikko et al, 2012), physical activity (Shin et al, 2014), thyroid disease (Kilic, Gulgun, Tascilar, Sari, & Yokusoglu, 2012) and ovulation in fertile women (Weissman et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Assessing heart rate variability in type 1 diabetes mellitus—Psychosocial stress a possible confounder

Kristiansen

Wanby

Åkesson

et al. 2020

Noninvasive Electrocardiol

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Background Autonomic neuropathy (AN) commonly arises as a long‐term complication in diabetes mellitus and can be diagnosed from heart rate variability (HRV), calculated from electrocardiogram recordings. Psychosocial stress also affects HRV and could be one of several confounders for cardiac AN. The present work investigated the impact of psychosocial stress on HRV in individuals with type 1 diabetes mellitus (T1DM) and assessed the use of salivary cortisol as a biomarker for psychosocial stress in this context. Methods A total of 167 individuals 6–60 years old (113 with T1DM and 54 healthy controls) underwent 24‐hr ECG recordings with HRV analysis. Salivary cortisol was sampled thrice during the registration day. Perceived psychosocial stress along with other factors of possible importance for the interpretation of HRV was documented in a diary. Results Heart rate variability (high‐frequency power during sleep) was reduced (p < .05) with older age, longer diabetes duration, higher mean glucose levels, physical inactivity, and perceived psychosocial stress. Salivary cortisol levels in the evening were increased (p < .05) in women in ovulation phase, in individuals with preceding hypoglycemia or with hyperglycemia. The amplitude of salivary cortisol was reduced (p < .05) with the presence of perceived psychosocial stress, but only in adult healthy controls, not in individuals with diabetes. Conclusion Psychosocial stress might be a confounder for reduced HRV when diagnosing cardiac AN in T1DM. Salivary cortisol is, however, not a useful biomarker for psychosocial stress in diabetes since the physiological stress of both hypoglycemia and hyperglycemia seems to overrule the effect of psychosocial stress on cortisol.

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“…O aumento da FC antes da realização de uma atividade física é conhecido como "resposta antecipatória da FC" 9,10 . Os mecanismos envolvidos na fisiologia do controle cardiovascular são complexos, e envolvem a interação entre os ramos simpático e parassimpático do sistema nervoso autônomo sobre a autorritimicidade do nódulo sinusal 2,[16][17][18][19][20][21][22][23][24][25] . Parece que, por fatores psicológicos estressantes, decorrentes da atividade a ser realizada, o sistema nervoso autônomo diminui o tônus vagal cardíaco, e aumenta a atividade nervosa simpática, fazendo com que a FC eleve seus valores, mesmo na situação de repouso.…”

Section: Discussionunclassified

Análise Da Frequência Cardíaca Em Repouso Registrada Pré-Teste De Exercício Máximo

Teixeira¹,

Moraes

Alves

et al. 2015

Revista Brasileira De Ciências Da Saúde - USCS

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O objetivo do presente estudo foi verificar a validade do valor registrado para frequência cardíaca em repouso (FCr) registrada imediatamente antes de um teste de exercício máximo. Por conveniência, 23 universitárias (21,8±2,8 anos; 57,9±10,2 kg; 163,6±5,5 cm) saudáveis e com experiência prévia no teste fizeram parte da amostra. Todas realizaram duas visitas ao laboratório de forma aleatória, uma delas apenas para registrar a FCr (sessão controle -CON), e na outra visita, além da FCr, foi realizado um teste de exercício máximo (sessão experimental -EXP), em esteira rolante, sob o protocolo de Bruce. Aplicouse, então, o teste t de Student para dados pareados com nível de significância de p<0,05. Os resultados demonstraram diferenças significativas nos valores de FCr entre as sessões CON (68,2±7,5 bpm) e EXP (71,9±7,8 bpm) (p=0,003), com aumento médio de 4 bpm, variando entre -7 a 17 bpm. Com isso, podemos concluir que os valores de FCr sofrem alterações quando registrados pré-testes de exercício máximo em jovens universitárias.Palavras-chave: Frequência cardíaca; exercício; sistema nervoso autônomo. RESUMO ABSTRACT 34This study aimed to verify the validity of the value for resting heart rate (RHR) recorded immediately before a maximal exercise test. For convenience, 23 university women (21.8±2.8 years, 57.9±10.2 kg, 163.6±5.5 cm) healthy and with previous experience in this test were enrolled. All subjects performed randomly two visits to the laboratory, one only to record the RHR and another followed to a test of maximal effort, using the treadmill Bruce protocol. It was applied the Student t-test for paired data with significance level of p<0.05. The results showed significant differences in RHR values between the control day (68.2±7.5 bpm) and pretest day (71.9±7.8 bpm) (p=0.003) with an average increase of 4 bpm, ranging from -7 to 17 bpm. Then, we conclude that the values of RHR unchanged when recorded before a maximal exercise test in young university women students.

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Cardiac Autonomic Regulation Is Disturbed in Children with Euthyroid Hashimoto Thyroiditis

Cited by 5 publications

References 23 publications

Heart rate variability in juvenile systemic lupus erythematosus patients

Heart rate variability in juvenile systemic lupus erythematosus patients

Assessing heart rate variability in type 1 diabetes mellitus—Psychosocial stress a possible confounder

Análise Da Frequência Cardíaca Em Repouso Registrada Pré-Teste De Exercício Máximo

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