Cardiac Arrhythmias Provoked by Focal Application of Delphinine

Scherf, David; Blumenfeld, Serge; Taner, Dogan; Yildiz, Muhtar

doi:10.1007/bf02119753

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…These tachycardias persist for long peri ods of time affording good opportunity for study. 1'he ventricular tachycardia caused by aconitine may change ultimately lo ventri cular fibrillation hut this is very rare with delphinine (5). livery attempt to terminate the tachycardia with striking the focus was successful but in two cases this procedure led lo ventricular fibrillation.…”

Section: Resultsmentioning

confidence: 99%

Experimental Study on Ventricular Tachycardia and Cardiac Trauma

Scherf¹,

Blumenfeld²,

Yıldız³

1964

Cardiology

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Section: Resultsmentioning

confidence: 99%

Experimental Study on Ventricular Tachycardia and Cardiac Trauma

Scherf¹,

Blumenfeld²,

Yıldız³

1964

Cardiology

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“…A few crystals of delphinine obtained through the generosity of Prof. Pelletier of the Rockefeller Institute in New York were applied to the lip of the left atrial appendix or the lower region of outer wall of the right atrium near the A-Y border, at the area of inflow of the inferior vena cava. It has been shown that focal application of delphinine on any area of the atria provokes flutter originating in the treated area (23). This method is ideal to produce a center of impulse formation in any desired spot of the atria.…”

Section: Methodsmentioning

confidence: 99%

Experimental Study of Ectopic Impulse Formation in the Left Atrium

Scherf¹,

Blumenfeld²,

Yıldız³

1963

Cardiology

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“…It is equally well known that different types of atrial arrhythmias can be produced in animals by local application of various drugs to the epicardial surface of the heart (Scherf, 1944(Scherf, , 1947Kisch, 1944;Scherf & Chick, 1951;Prinzmetal, Corday, Brill, Oblath & Kruger, 1952;Scherf, Blumenfeld, Taner & Yildiz, 1960), but it has never been shown that any of these resemble paroxysmal atrial tachycardia in man by the crucial test of being consistently suppressible by means of carotid sinus stimulation. It has now been found that the arrhythmia produced by subepicardial injection of ouabain is regularly susceptible to carotid sinus stimulation.…”

mentioning

confidence: 99%

Suppression of Ouabain‐induced Atrial Arrhythmias by Carotid Sinus Stimulation

Schott

1961

British Journal of Pharmacology and Chemotherapy

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In dogs anaesthetized with chloralose ectopic atrial arrhythmias were produced by subepicardial injection of ouabain. Stimulation of the right carotid sinus abruptly suppressed the ectopic arrhythmias. They returned on cessation of stimulation and sometimes already during the period of stimulation. It is suggested that in view of its response to carotid sinus stimulation the ouabain-induced arrhythmia resembles paroxysmal atrial tachycardia and that it is distinct from the aconitine-induced arrhythmia which on account of its response to vagal stimulation has been classified as atrial flutter.It is well known to clinicians that attacks of atrial paroxysmal tachycardia can often be terminated by carotid sinus pressure whereas this procedure is ineffective in atrial flutter. It is equally well known that different types of atrial arrhythmias can be produced in animals by local application of various drugs to the epicardial surface of the heart (Scherf, 1944(Scherf, , 1947Kisch, 1944;Scherf & Chick, 1951;Prinzmetal, Corday, Brill, Oblath & Kruger, 1952;Scherf, Blumenfeld, Taner & Yildiz, 1960), but it has never been shown that any of these resemble paroxysmal atrial tachycardia in man by the crucial test of being consistently suppressible by means of carotid sinus stimulation. It has now been found that the arrhythmia produced by subepicardial injection of ouabain is regularly susceptible to carotid sinus stimulation. METHODSDogs weighing between 9 and 14 kg were premedicated with morphine, 1 mg/kg injected subcutaneously, and anaesthetized with chloralose, 0.1 g/kg injected intravenously. The blood pressure was recorded from a femoral artery and a cannula was inserted into the trachea.In all experiments stimulation of the carotid sinus was carried out on the right side with both sinus and aortic nerves intact in order to approximate the effects obtained in man, where pressure on the right carotid sinus is more frequently effective in terminating attacks of atrial paroxysmal tachycardia (Scherf & Schott, 1953). The right carotid sinus was exposed, and stimulating shielded platinum electrodes were applied to the dissected sinus nerve and connected to a transistor stimulator (Joslin, 1959). Stimulation was carried out with impulses of 15 V, 1 msec, 100/sec. In a few experiments the innervated right carotid sinus was isolated, according to the method of Moissejeff (1927), making possible its distension by introducing liquid into it, and at the same time recording the intrasinusal pressure.After dissection of the carotid sinus, the sternum was split, the chest opened in the midline to expose the heart, while artificial respiration was given with a Starling (" Ideal ") pump.

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Cardiac Arrhythmias Provoked by Focal Application of Delphinine

Cited by 8 publications

References 4 publications

Experimental Study on Ventricular Tachycardia and Cardiac Trauma

Experimental Study on Ventricular Tachycardia and Cardiac Trauma

Experimental Study of Ectopic Impulse Formation in the Left Atrium

Suppression of Ouabain‐induced Atrial Arrhythmias by Carotid Sinus Stimulation

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