Cardiac Arrhythmias in Patients with End Stage Renal Disease (ESRD) on Hemodialysis; Recent Update and Brief Literature Review

Ajam, Firas

doi:10.11648/j.ajim.20190701.16

Cited by 3 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Repolarization abnormalities play a fundamental role in the genesis of arrhythmic events and the risk increases in patients at ESRD with imbalance in 41 . In this work, two previously reported potassium estimators, 14 and 15 , four warping-based ECG-derived biomarkers for monitoring proposed in Ramírez et al 17 , , , , , and the here proposed modified versions and were tested as bloodless indices for variations in ESRD-HD patients computed from standard leads as well as in a PCA-derived lead.…”

Section: Discussionmentioning

confidence: 99%

“…Repolarization abnormalities play a fundamental role in the genesis of arrhythmic events and the risk increases in patients at ESRD with imbalance in [K + ] 41 . In this work, two previously reported potassium estimators, T w 14 and T S/A 15 , four warping-based ECG-derived biomarkers for [K + ] monitoring proposed in Ramírez et al 17 The signed biomarker d w followed a similar time-course as the unsigned d u w during the whole monitoring period, showing a similar distribution in Fig.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Monitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics

Palmieri

Gomis

Ferreira³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

We investigated the ability of time-warping-based ECG-derived markers of T-wave morphology changes in time ($$d_{w}$$ d w ) and amplitude ($$d_a$$ d a ), as well as their non-linear components ($${d_w^{{\mathrm{NL}}}}$$ d w NL and $${d_a^{\mathrm{NL}}}$$ d a NL ), and the heart rate corrected counterpart ($$d_{w,c}$$ d w , c ), to monitor potassium concentration ($$[K^{+}]$$ [ K + ] ) changes ($$\Delta [K^+]$$ Δ [ K + ] ) in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). We compared the performance of the proposed time-warping markers, together with other previously proposed $$[K^{+}]$$ [ K + ] markers, such as T-wave width ($$T_w$$ T w ) and T-wave slope-to-amplitude ratio ($$T_{S/A}$$ T S / A ), when computed from standard ECG leads as well as from principal component analysis (PCA)-based leads. 48-hour ECG recordings and a set of hourly-collected blood samples from 29 ESRD-HD patients were acquired. Values of $$d_w$$ d w , $$d_a$$ d a , $${d_w^{\mathrm{NL}}}$$ d w NL , $${d_a^{\mathrm{NL}}}$$ d a NL and $$d_{w,c}$$ d w , c were calculated by comparing the morphology of the mean warped T-waves (MWTWs) derived at each hour along the HD with that from a reference MWTW, measured at the end of the HD. From the same MWTWs $$T_w$$ T w and $$T_{S/A}$$ T S / A were also extracted. Similarly, $$\Delta [K^+]$$ Δ [ K + ] was calculated as the difference between the $$[K^{+}]$$ [ K + ] values at each hour and the $$[K^{+}]$$ [ K + ] reference level at the end of the HD session. We found that $$d_{w}$$ d w and $$d_{w,c}$$ d w , c showed higher correlation coefficients with $$\Delta [K^+]$$ Δ [ K + ] than $$T_{S/A}$$ T S / A —Spearman’s ($$\rho$$ ρ ) and Pearson’s (r)—and $$T_w$$ T w —Spearman’s ($$\rho$$ ρ )—in both SL and PCA approaches being the intra-patient median $$\rho \ge 0.82$$ ρ ≥ 0.82 and $$r \ge 0.87$$ r ≥ 0.87 in SL and $$\rho \ge 0.82$$ ρ ≥ 0.82 and $$r \ge 0.89$$ r ≥ 0.89 in PCA respectively. Our findings would point at $$d_{w}$$ d w and $$d_{w,c}$$ d w , c as the most suitable surrogate of $$\Delta [K^+]$$ Δ [ K + ] , suggesting that they could be potentially useful for non-invasive monitoring of ESRD-HD patients in hospital, as well as in ambulatory settings. Therefore, the tracking of T-wave morphology variations by means of time-warping analysis could improve continuous and remote $$[K^{+}]$$ [ K + ] monitoring of ESRD-HD patients and flagging risk of $$[K^{+}]$$ [ K + ] -related cardiovascular events.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Monitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics

Palmieri

Gomis

Ferreira³

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In the middle panel (j), the width and amplitude of the T wave are shown to increase with increasing RR, which is accompanied by changes in the T wave shape. [10], [35]- [39]. The availability of non-invasive tools to monitor serum [K + ] and [Ca 2+ ] concentrations, particularly in ESRD patients, might have a significant impact on clinical practice.…”

Section: Simulated T Wavesmentioning

confidence: 99%

Characterization of T Wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship With Serum Electrolyte Levels and Heart Rate

Bukhari

Palmieri

Ramírez

et al. 2021

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

Objective: Chronic kidney disease affects 7 more than 10% of the world population. Changes in serum 8 ion concentrations increase the risk for ventricular ar-9 rhythmias and sudden cardiac death, particularly in end-10 stage renal disease (ESRD) patients. We characterized how 11 T wave amplitude, duration and morphology descriptors 12 change with variations in serum levels of potassium and 13 calcium and in heart rate, both in ESRD patients and in 14 simulated ventricular fibers. Methods: Electrocardiogram 15 (ECG) recordings from twenty ESRD patients undergoing 16 hemodialysis (HD) and pseudo-ECGs (pECGs) calculated 17 from twenty-two simulated ventricular fibers at varying 18 transmural heterogeneity levels were processed to quantify 19 T wave width (T w ), T wave slope-to-amplitude ratio (T S/A ) 20 and four indices of T wave morphological variability based 21 on time warping (d w , d NL w , d a and d NL a ). Serum potassium 22 and calcium levels and heart rate were measured along 23 HD. Results: d NL a was the marker most strongly correlated 24

show abstract

“…Имеются единичные сообщения и одноцентровые исследования об имплантации этих устройств у пациентов с ХБП, как альтернативы антикоагулянтной терапии [30,31]. В настоящее время идет рандомизированное исследование Left Atrial Appendage Occlusion vs. Usual Care in Patients With Atrial Fibrillation and Severe Chronic Kidney Disease (WatchAFIB), которое, возможно, позволит уточнить показания к использованию этих устройств в этой группе пациентов [32].…”

Section: таблица 3 использование антиаритмических препаратов и препаunclassified

Atrial fibrillation in patients with chronic kidney disease

Melnikov

Yashin

2020

Vestnik aritmologii

View full text Add to dashboard Cite

show abstract

Cardiac Arrhythmias in Patients with End Stage Renal Disease (ESRD) on Hemodialysis; Recent Update and Brief Literature Review

Cited by 3 publications

References 25 publications

Monitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics

Monitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics

Characterization of T Wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship With Serum Electrolyte Levels and Heart Rate

Atrial fibrillation in patients with chronic kidney disease

Contact Info

Product

Resources

About