Cardiac arrest during induction of anaesthesia in a child on long-term amphetamine therapy

Perruchoud, Christophe; Chollet-Rivier, Madeleine

doi:10.1093/bja/aen012

Cited by 18 publications

(7 citation statements)

References 5 publications

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“…Similar results were reported by Chambers et al . in children who were anesthetized with 1 MAC sevoflurane for 10 min, although the control group was composed of patients without ADHD. The present study included a control group composed of children with ADHD who did not take stimulant medication prior to surgery, allowing comparison between individuals with similar underlying central nervous system dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…The authors hypothesized that the acute stimulant effect of methylphenidate increased the dose requirement for medications to achieve procedural sedation or general anesthesia. Perruchoud and Chollet‐Rivier reported cardiac arrest following the induction of general anesthesia in a 10‐year‐old patient, receiving chronic methylphenidate therapy for ADHD . The authors concluded that anesthetic agents with cardiac depressant effects should be avoided or “carefully” titrated in these patients.…”

Section: Introductionmentioning

confidence: 99%

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Hemodynamic profile and behavioral characteristics during induction of anesthesia in pediatric patients with attention deficit hyperactivity disorder

Cartabuke

Tobias

Rice

et al. 2017

Pediatric Anesthesia

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The evidence suggests that continuing preoperative stimulant medication is not associated with cardiovascular instability in the pediatric population. The evidence suggests that withholding or allowing stimulant medication preoperatively does not improve behavior on anesthetic induction or reduce the need for anxiolytic medication. Research efforts should focus on perioperative management strategies that will decrease the likelihood of long-term behavioral issues.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hemodynamic profile and behavioral characteristics during induction of anesthesia in pediatric patients with attention deficit hyperactivity disorder

Cartabuke

Tobias

Rice

et al. 2017

Pediatric Anesthesia

View full text Add to dashboard Cite

show abstract

“…Bradycardia and refractory hypotension have been reported in children with attention deficit hyperactivity disorder who were undergoing surgery and chronically treated with methylphenidate [42].…”

Section: -Tension Pneumothoraxmentioning

confidence: 99%

Cardiac Arrest in Children

Lampugnani

Lerman

Grasso

et al. 2017

Curr Anesthesiol Rep

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Perioperative cardiac arrest in children is a rare but catastrophic adverse event. It is difficult to investigate the incidence, risk factors, causes, and outcomes from these events, but the exercise is extremely useful in order to develop strategies to prevent it. Recent data identified several major risk factors for cardiac arrest in children: American Society of Anesthesiologists (ASA) physical status >3, age <1 year, and lack of specific pediatric experience by the healthcare providers. Since 1994, when the Perioperative Cardiac Arrest (POCA) Registry was created, the frequency of medicationrelated causes of cardiac arrest in children has decreased while the frequency of respiratory and cardiovascular causes has increased. The International Liaison Committee on Resuscitation Consensus Conference adopted the "5H+5T" acronym for the reversible causes of pediatric cardiac arrest: hypoxia, hypovolemia, hyper/hypokalemia, hypothermia, tension pneumothorax, cardiac tamponade, toxins, and cardiopulmonary thromboembolism. In this review article, the pathophysiology, diagnostic pathway, and treatment of perioperative cardiac arrest in children will be addressed. The importance of a certified training of anesthesiologists in pediatric advanced life support is also highlighted.

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“…The specific adverse effects of excessive perioperative alcohol use include biochemical and hematological abnormalities (even in the absence of liver disease), altered drug kinetics and acute withdrawal (Chapman and Plaat, 2009). Preoperative use of other recreational substances (ORSU) has also been shown to be detrimental, though evidence is nascent: cannabis can potentiate or antagonize anesthetic drugs, presenting considerable risks (Dickerson, 1980; Mallat et al, 1996; Symons, 2002; White, 2002; Kuczkowski, 2004; Sharma et al, 2012); cocaine and amphetamine present cardiovascular issues (including intraoperative deaths) (Samuels et al, 1979; Steadman and Birnbach, 2003; Inouye et al, 2004; Skerman, 2005; Perruchoud and Chollet-Rivier, 2008; Baxter and Alexandrov, 2012; Elkassabany et al, 2013); and opioid users vs. non-users, independent of various comorbidities and surgical procedures, have up-to four times the odds of dying and two times the odds of suffering any morbidity in the perioperative period (Menendez et al, 2015). Lastly, a myriad of novel psychoactive substances have flooded the European market, many of which are demonstrably easy to acquire (e.g., legally) (Martinotti et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Preoperative Interventions for Alcohol and Other Recreational Substance Use: A Systematic Review and Meta-Analysis

et al. 2019

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Background: Preoperative alcohol and other recreational substance use (ORSU) may catalyze perioperative complications. Accordingly, interventions aiming to reduce preoperative substance use are warranted.Methods: Studies investigating interventions to reduce alcohol and/or ORSU in elective surgery patients were identified from: Cochrane Library; MEDLINE; PSYCINFO; EMBASE; and CINAHL. In both narrative summaries of results and random effects meta-analyses, effects of interventions on perioperative alcohol/ORSU, complications, mortality and length of stay were assessed.Primary Results: Nine studies (n = 903) were included. Seven used behavioral interventions only, two provided disulfiram in addition. Pooled analyses found small effects on alcohol use (d: 0.34; 0.05–0.64), though two trials using disulfiram (0.71; 0.36–1.07) were superior to two using behavioral interventions (0.45; −0.49–1.39). No significant pooled effects were found for perioperative complications, length of hospital stay or mortality in studies solely targeting alcohol/ORSU. Too few interventions targeting ORSU (n = 1) were located to form conclusions regarding their efficacy. Studies were generally at high risk-of-bias and heterogeneous.Conclusions: Preoperative interventions were beneficial in reducing substance use in some instances, but more high-quality studies targeting alcohol/ORSU specifically are needed. The literature to date does not suggest that such interventions can reduce postoperative morbidity, length of hospital stay or mortality. Limitations in the literature are outlined and recommendations for future studies are suggested.

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Cardiac arrest during induction of anaesthesia in a child on long-term amphetamine therapy

Cited by 18 publications

References 5 publications

Hemodynamic profile and behavioral characteristics during induction of anesthesia in pediatric patients with attention deficit hyperactivity disorder

Hemodynamic profile and behavioral characteristics during induction of anesthesia in pediatric patients with attention deficit hyperactivity disorder

Cardiac Arrest in Children

Preoperative Interventions for Alcohol and Other Recreational Substance Use: A Systematic Review and Meta-Analysis

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