Cardiac Angiosarcoma Management and Outcomes: 20-Year Single-institution Experience

Hong, Nicole J. Look; Pandalai, Prakash K.; Hornick, Jason L.; Shekar, Prem; Harmon, David C.; Chen, Yen‐Lin; Butrynski, James E.; Baldini, Elizabeth H.; Raut, Chandrajit P.

doi:10.1245/s10434-012-2334-2

Cited by 111 publications

(78 citation statements)

References 32 publications

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“…Angiosarcoma is a very aggressive malignant neoplasm with a short fatal clinical process, despite new, cutting edge, treatment modalities, such as extensive surgery, radiotherapy, and chemotherapy 12. Nowadays, through advanced diagnostic technology, such as high-resolution CT, dynamic magnetic resonance imaging, and PET-CT, clinicians are able to diagnose in a shorter time, which allows for more effective radical surgical resection.…”

Section: Resultsmentioning

confidence: 99%

Cardiac angiosarcoma: utility of [18F]fluorodeoxyglucose positron emission tomography–computed tomography in evaluation of residue, metastases, and treatment response

Tokmak

Demir²,

Demirkol³

2014

VHRM

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Cardiac angiosarcomas are a rare form of malignancy. The majority of cases arise from the right atrium as mural masses. These tumors have extremely aggressive behavior, with early clinical symptoms that vary depending on location, size, and extent of the tumor. Most of these patients have a very short survival time. Surgical therapy is considered the best choice of therapy approach in cardiac angiosarcoma patients with nonmetastatic disease, even though the disease is rarely cured. Advanced diagnostic techniques facilitate accurate, noninvasive assessments of cardiac sarcomas. We report a case of a 62-year-old man with cardiac angiosarcoma who had multiple distant metastases that were revealed by [18F]fluorodeoxyglucose positron emission tomography–computed tomography imaging.

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Section: Resultsmentioning

confidence: 99%

Cardiac angiosarcoma: utility of [18F]fluorodeoxyglucose positron emission tomography–computed tomography in evaluation of residue, metastases, and treatment response

Tokmak

Demir²,

Demirkol³

2014

VHRM

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“…[4] Frequently, patients present with symptoms of pericardial effusion or tamponade because as the tumor rapidly grows into the myocardium, it tends to bleed. [6,7] When pericardiocentesis is performed, cytologic examination is often negative.…”

Section: Discussionmentioning

confidence: 99%

“…[6,7] When pericardiocentesis is performed, cytologic examination is often negative. [4,8,9] PCAs are highly aggressive tumors, with approximately 66% to 89% metastatic at diagnosis. [10] When they are metastatic, the presenting symptoms may be related to the metastatic burden of the organ systems.…”

Section: Discussionmentioning

confidence: 99%

“…[3] Men are affected more frequently than women by angiosarcoma -at a ratio of approximately 3:1 -and the right atrium (RA) is the most frequent location. [4] The differential diagnoses for a cardiac mass include atrial myxoma, thrombus, metastatic disease, and primary cardiac malignancy such as angiosarcoma, rhabdomyosarcoma, osteosarcoma, and cardiac lymphoma. [3,5] Herein, we present the case of a woman with nausea, vomiting, and epigastric pain who eventually received the diagnosis of a large cardiac angiosarcoma.…”

Section: Introductionmentioning

confidence: 99%

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Nausea and vomiting masquerading heart cancer

Shapiro

Vasile

Klarich

et al. 2016

JST

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Primary cardiac tumors are extremely rare, although only 20% are malignant. Of the malignant tumors, sarcomas are the most common type and usually present with signs and symptoms of pericardial effusion or tamponade, including dyspnea, chest pain, or syncope. We present the case of a woman with nausea, vomiting, and epigastric pain who eventually received the diagnosis of a large cardiac angiosarcoma. To our knowledge, no case reports have described patients with primary cardiac tumors presenting with nausea and vomiting without cardiac symptoms. Our patient was treated with open heart resection of the tumor and reconstruction of the right atrium with bovine pericardium. This case highlights an atypical presentation of this rare condition and shows the current optimal management.

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“…Heart transplantation has been considered as a final treatment option in individual cases, especially in young patients with no other treatment option,27 but the reported outcomes are discouraging 28…”

Section: Discussionmentioning

confidence: 99%

Cardiac angiosarcoma: an unexpected diagnosis

Crenitte¹,

Galvão²,

Bernardi³

et al. 2014

ACR

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Cardiac angiosarcoma is a rare entity. The incidence through autopsy findings ranges between 0.001% and 0.03%. The disease usually presents with non-specific symptoms, although asymptomatic cases are frequent; therefore, diagnosis is unexpected and consequently delayed. The authors report the case of a middle-aged man with a recent onset cough and dyspnea. He sought medical care several times without receiving a definite diagnosis until a plain chest radiography was taken showing a mediastinal enlargement, which was the reason why he was hospitalized for clinical investigation. During the diagnostic workup, an echodopplercardiogram and a thoracic computed tomography were performed, showing a heterogeneous soft-tissue mass infiltrating the pericardium and the anterior atrial wall. Multiple and scattered pulmonary nodules were also present. A pulmonary nodule was biopsied, which revealed an angiosarcoma. The clinical features added to the radiological and histological findings permitted the diagnosis of right atrial angiosarcoma. The authors highlight the unexpected pattern in the presentation of cardiac tumors.

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Cardiac Angiosarcoma Management and Outcomes: 20-Year Single-institution Experience

Cited by 111 publications

References 32 publications

Cardiac angiosarcoma: utility of [18F]fluorodeoxyglucose positron emission tomography–computed tomography in evaluation of residue, metastases, and treatment response

Cardiac angiosarcoma: utility of [18F]fluorodeoxyglucose positron emission tomography–computed tomography in evaluation of residue, metastases, and treatment response

Nausea and vomiting masquerading heart cancer

Cardiac angiosarcoma: an unexpected diagnosis

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Cardiac Angiosarcoma Management and Outcomes: 20-Year Single-institution Experience

Cited by 111 publications

References 32 publications

Cardiac angiosarcoma: utility of [18F]fluorodeoxyglucose positron emission tomography&ndash;computed tomography in evaluation of residue, metastases, and treatment response

Cardiac angiosarcoma: utility of [18F]fluorodeoxyglucose positron emission tomography&ndash;computed tomography in evaluation of residue, metastases, and treatment response

Nausea and vomiting masquerading heart cancer

Cardiac angiosarcoma: an unexpected diagnosis

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Product

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About

Cardiac angiosarcoma: utility of [18F]fluorodeoxyglucose positron emission tomography–computed tomography in evaluation of residue, metastases, and treatment response

Cardiac angiosarcoma: utility of [18F]fluorodeoxyglucose positron emission tomography–computed tomography in evaluation of residue, metastases, and treatment response