Cardiac and Pulmonary Involvement in Behcet's Disease

El-Ramahi, Kamal M.; Fawzy, Mohamed; Sieck, Jens O.; Vanhaleweyk, G.

doi:10.3109/03009749109096815

Cited by 45 publications

(24 citation statements)

References 11 publications

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“…Table 4 presents the data about non-PAA macroscopic and microscopic vascular disease [47,48,49,50,51,52,53,54,55,56,57,58]. Evaluation of published cases and outcome of our patients indicate that anticoagulation may not be dangerous in non-PAA macroscopic and microscopic vascular disease compared to PAA in BD.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Involvement in Behçet’s Disease

Uzun

Erkan

Akpolat³

et al. 2007

Respiration

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Background: Behçet’s disease (BD) is a multisystem vasculitis and pulmonary involvement in BD is reported to indicate poor prognosis and high mortality. Objectives: The aims of this study were to report on patients with pulmonary involvement and to discuss pulmonary artery thrombus and small-sized vasculitis associated with BD, with respect to previously published cases. Methods: Fifteen patients with BD and pulmonary involvement were included in this study. Massive hemoptysis was observed in all patients having pulmonary artery aneurysm (PAA). Results: Eleven patients had macroscopic pulmonary vascular disease (2 PAA, 3 PAA and thrombi and 6 only thrombi) and 3 patients had microscopic pulmonary vascular disease. The remaining patient had pulmonary cryptococcosis. Conclusions: Data regarding treatment and outcomes of patients having BD-related pulmonary emboli/infarct and small-sized vasculitis are limited. Pulmonary vasculitis affects different levels of the pulmonary artery in BD and should be classified as macroscopic and microscopic vascular disease. ‘Pulmonary artery thrombosis’ should be used instead of ‘pulmonary emboli’. Spiral CT angiography is the best radiological tool for evaluation of pulmonary problems in BD. Treatment of vasculitis should be based on the type of vascular disease and may vary among different types of vascular disease. Anticoagulation can be used in patients with microscopic vascular disease and nonaneurysmal macroscopic vascular disease. More studies are needed to clarify this issue.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Involvement in Behçet’s Disease

Uzun

Erkan

Akpolat³

et al. 2007

Respiration

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“…We have previously reported on the successful lysis of multiorgan thrombi in two patients with Behcet's disease [3]. Hereby, we report the successful use of streptokinase in two patients with intracardiac thrombi in the setting of renal failure.…”

Section: Introductionmentioning

confidence: 81%

Successful Lysis of Intra-Cardiac Thrombi with Streptokinase in Patients with Renal Failure; Two Case Reports and Review of the Literature

Hassan

Elshaer

Fawzy

et al. 2004

J Thromb Thrombolysis

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In situ formation of thrombi within the cardiac cavities carries a substantial risk of morbidity and mortality due to the inherent danger of embolization to vital organs. This typically occurs in patients with underlying cardiac disorders associated with low flow state favoring regional stagnation of blood and subsequent clotting. Occasionally, extra-cardiac conditions such as renal failure predispose to the development of intra-cardiac thrombi in the presence or absence of identifiable cardiac abnormalities. Once identified, the appropriate treatment of such thrombi remains highly controversial. Here, we report on the successful and safe use of streptokinase in two patients with end stage renal disease with high risk left ventricular, right ventricular and right atrial thrombi.

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“…Only 10 cases have been reported to date in the English literature. [3][4][5][6][7][8][9][10][11] As well, pulmonary involvement with this disease is rare, with the usual clinical presentation of pulmonary involvement being recurrent massive hemoptysis. 10,12 Repetitive pulmonary embolism has been reported in only 3 cases.…”

Section: Discussionmentioning

confidence: 99%