1987
DOI: 10.1210/endo-121-1-241
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Cardiac and Plasma Atrial Natriuretic Factor in Experimental Congestive Heart Failure*

Abstract: Synthesis-secretion coupling of insulin was measured in four age groups of perfused pancreases taken from Sprague-Dawley rats ranging in age from 2-12 months. The effect of long term (6 h) near-maximal glucose stimulation (300 mg/dl) on both insulin secretion and net insulinogenesis demonstrated an age-related increase in both parameters. Net insulinogenesis as well as total insulin secretion increased linearly as a function of aging. Compared to that in 2-month-old rats, total net insulin synthesis was more t… Show more

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Cited by 21 publications
(22 citation statements)
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“…Since the pioneering work of de Bold and his co-workers (11 ) ANP has been thought to be secreted from the atria and not from the ventricles in adult mammals (1)(2)(3)(4)(5)12 33 pertrophy or heart failure (13)(14)(15)(16)(17) in animals. Recently, Edwards and his co-workers demonstrated immunohistochemically the presence of immunoreactive ANP in the ventricles of autopsied and biopsied humans with heart failure, but not in the control autopsied human hearts (19).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Since the pioneering work of de Bold and his co-workers (11 ) ANP has been thought to be secreted from the atria and not from the ventricles in adult mammals (1)(2)(3)(4)(5)12 33 pertrophy or heart failure (13)(14)(15)(16)(17) in animals. Recently, Edwards and his co-workers demonstrated immunohistochemically the presence of immunoreactive ANP in the ventricles of autopsied and biopsied humans with heart failure, but not in the control autopsied human hearts (19).…”
Section: Discussionmentioning
confidence: 99%
“…However, several recent reports have demonstrated that the ventricle is capable of synthesizing and storing substantial amounts of ANP during cardiac hypertrophy and failure in rats and hamsters (13)(14)(15)(16)(17). We have reported a patient with dilated cardiomyopathy (DCM) who died of congestive heart failure; the patient showed very high levels of plasma ANP and increased tissue levels of both ANP and ANP mRNA in the left ventricle at autopsy (18).…”
Section: Introductionmentioning
confidence: 98%
“…Increased ventricular ANP synthesis has been demonstrated in patients with congestive heart failure (Edwards et al, 1988;Tsuchimochi et al, 1988;Saito et al, 1989) and in animal models of pressure and volume overload. These models include spontaneous biventricular hypertrophy , genetic hypertension (Arai et al, 1988), congestive heart failure in cardiomyopathic hamsters (Edwards et al, 1988;Ding et al, 1988), hypoxia (Stockmann et al, 1988), administration of high doses of pharmacological agents (Gardner et al, 1986b;Day et al, 1987;Ruskoaho & Leppaluoto, 1988), or sudden circulatory overload due to aortic constriction, myocardial infarction, or arteriovenous shunting (Lattion et al, 1986;Day et al, 1987;Michel et al, 1988). Whether the increased synthesis and storage of ANP by ventricles results in significant secretion of ANP by the ventricles is unknown.…”
Section: Introductionmentioning
confidence: 99%
“…Since ANP was first discovered from atrial tissues, the atrium had been thought to be the sole source of circulating ANP (4,(13)(14)(15)(16). There is growing evidence, however, indicating that ANP is also synthesized in the ventricle of normal animals (17-19) and that ANP synthesis in the ventricle is increased under certain pathological conditions, such as spontaneously hypertensive rats (SHR) (20,21), SHR stroke-prone (20), cardiomyopathic hamsters (22), experimentally volume or pressure overloaded rats (23)(24)(25), and myocarditis mice (26). In evaluating ANP synthesis in the human failing heart, it is, therefore, necessary to investigate ANP synthesis not only in the atrium but also in the ventricle.…”
mentioning
confidence: 99%