Cardiac anaplastic large cell lymphoma in an 8-year old boy

Lauten, Melchior; Vieth, Simon; Hart, Christopher; Wößmann, Wilhelm; Tröger, Birte; Härtel, Christoph; Bethge, Martin; Schrauder, André; Cario, Gunnar

doi:10.1016/j.lrr.2014.05.001

Cited by 7 publications

(6 citation statements)

References 10 publications

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“…Also cardiac ischemia resulting from lymphomatous deposits has been described . Sudden death may occur as a result of ventricular rupture, acute myocardial infarction, or ventricular arrythmias .…”

Section: Discussionmentioning

confidence: 99%

Primary cardiac lymphoma with central nervous system relapse

Rooijen

Scholtens

Jong

et al. 2017

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Primary cardiac lymphoma with central nervous system relapse

Rooijen

Scholtens

Jong

et al. 2017

Clinical Case Reports

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“…We found a few case reports of cardiac involvement with ALCL, all of which occurred in patients between 8 and 29 years of age [15][16][17][18][19]. All these cases were ALCL ALK+, and only one report showed localized (= primary) cardiac lymphoma [15]. In all published cases, the cardiac involvement was identified based on clinical symptoms (syncopal episode, arrhythmia, heart failure).…”

Section: Discussionmentioning

confidence: 99%

“…We found some case reports on cardiac ALCLs in children or very young people in the literature [15][16][17][18][19]. We added the retrospective analysis of cardiac involvement in newly diagnosed lymphomas based on data from the Czech Lymphoma Study Group (CLSG) database, as most reported incidence of cardiac lymphoma was derived from the autopsies of patients with advanced disease or a set of cardiac tumors [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

An anaplastic cardiac large cell lymphoma: A case report and analysis of cardiac involvement in newly diagnosed non-Hodgkin’s lymphoma from the Czech Lymphoma Study Group (CLSG) database

Lobello¹,

Janíková²,

Křen³

et al. 2017

J Cancer Res Ther.

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We report a rare case of anaplastic large cell ALK+ lymphoma (ALCL) with initial asymptomatic cardiac involvement. A 59-year-old male with infiltration of the right ventricular wall underwent standard combined chemotherapy (CHOP) and achieved remission without significant cardiac impairment. Additionally, we report the actual incidence of cardiac lymphoma in newly diagnosed non-Hodgkin Lymphomas (NHLs). In total, 16 patients with cardiac lymphoma were found (0.1% NHLs) in the Czech Lymphoma Study Group database. DLBCL was the most frequent histology subtype (50%), and ALCL was identified in 12.5% of cases. At initial diagnosis, the median age was 55.5 (range 21-74) years and 59% were men. None of the 16 patients with cardiac involvement had isolated heart lymphoma. The response to first-line therapy was 79% in 14/16 evaluable patients. The median progression-free survival and overall survival were nearly the sameapproximately 3.5 years (range; 0.05-16.7ys), while the median follow up was 4 years.

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“…Pediatric ALCL with cardiac involvement at diagnosis is rare. Currently, only 2 cases are known to have been reported: an 8-year-old primary cardiac ALCL patient [ 9 ] and a 2-year-old ALCL patient with cardiac tamponade [ 10 ]. Pediatric ALCL with cardiac involvement, like pediatric ALCL in general, seems to respond favorably to steroids and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma with Cardiac Metastasis and Arterial Tumor Embolisms during First-Course Chemotherapy

et al. 2016

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We described an 11-year-old boy suffering from pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with heart metastasis at diagnosis and arterial tumor embolisms during chemotherapy. Both the heart metastasis and pericardial effusion showed improvement with prednisolone, but numbness and pallor sequentially developed in his lower extremities during the first course of chemotherapy. Contrast-enhanced imaging revealed occlusion of the right anterior tibial artery and left popliteal artery. These symptoms were spontaneously remitted due to the compensation of other arteries. Arterial tumor embolism is a rare but possible complication when a lymphoma shows intracardiac infiltration.

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Cardiac anaplastic large cell lymphoma in an 8-year old boy

Cited by 7 publications

References 10 publications

Primary cardiac lymphoma with central nervous system relapse

Primary cardiac lymphoma with central nervous system relapse

An anaplastic cardiac large cell lymphoma: A case report and analysis of cardiac involvement in newly diagnosed non-Hodgkin’s lymphoma from the Czech Lymphoma Study Group (CLSG) database

Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma with Cardiac Metastasis and Arterial Tumor Embolisms during First-Course Chemotherapy

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