Cardiac Amyloidosis Shows Decreased Diastolic Function as Assessed by Echocardiographic Parameterized Diastolic Filling

Salman, Katrin; Cain, Peter; Fitzgerald, B.; Sundqvist, Martin

doi:10.1016/j.ultrasmedbio.2017.02.014

Cited by 8 publications

(6 citation statements)

References 24 publications

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“…Studies related to cardiac damage processes such as diastolic function, restrictive cardiomyopathy, and congestive heart failure in amyloidosis have been maintained at a high research fever level [ 14 – 16 ]. Diastolic dysfunction can be observed in CA patients on echocardiography (significant decrease of Ev velocity in all walls of the heart, lateral side < or = − 12 cm/s, medial side < or = − 10 cm/s,) [ 17 , 18 ] In contrast, restrictive cardiomyopathy and hypertrophic cardiomyopathy may be phenotypes of CA, associated with amyloid deposits that infiltrate the myocardial interstitium and “sclerosis” and hypertrophy of the heart [ 19 , 20 ] CA may be an under-recognized cause of heart failure, especially in HFpEF [ 21 ].…”

Section: Discussion and Prospectsmentioning

confidence: 99%

Research trends and hotspots evolution of cardiac amyloidosis: a bibliometric analysis from 2000 to 2022

Gao

et al. 2023

Eur J Med Res

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In the new century, cardiac amyloidosis has received more attention from many countries and institutions, leading to innovations in the essence of the pathology, biological markers, noninvasive tests, and staging diagnoses and treatments for this disease. However, few reviews have summarized the research trends and hotspots in cardiac amyloidosis. Bibliometrics analysis is a statistically based approach to research that visualizes the contributions of academic institutions and changes in research hotspots. Therefore, in this paper, we used Citespace and VOSviewer software to conduct co-occurrence analysis and collaborative network analysis on the countries, institutions, and authors in the articles related to cardiac amyloidosis since the new century. And further find out burst keywords and references to obtain the research history, disciplinary development, and new hotspots and topics.

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Section: Discussion and Prospectsmentioning

confidence: 99%

Research trends and hotspots evolution of cardiac amyloidosis: a bibliometric analysis from 2000 to 2022

Gao

et al. 2023

Eur J Med Res

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“…Indices of diastolic dysfunction may be indicative of early stages of the disease prior to the detection of gross morphological changes but may be nonspecific (50) ( Figures 1E-G). A higher E/e' and a larger left atrial area, reflective of diastolic dysfunction has been reported in patients with amyloidosis which is attributed to increased stiffness in the myocardium as a result of amyloid protein deposition (7). Additionally, a greater reduction in deceleration time of early filling, and a lower indexed LV mass, have been reported in AL in comparison to TTR amyloidosis, assisting the differentiation of the two pathologies (8) (Figure 1H).…”

Section: Echocardiography Transthoracic Echocardiographymentioning

confidence: 83%

The Role of Multi-modality Imaging in the Diagnosis of Cardiac Amyloidosis: A Focused Update

Khanna

Wen

Bhat

et al. 2020

Front. Cardiovasc. Med.

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Cardiac amyloidosis (CA) is a unique disease entity involving an infiltrative process, typically resulting in a restrictive cardiomyopathy with diastolic heart failure that ultimately progresses to systolic heart failure. The two most common subtypes are light-chain and transthyretin amyloidosis. Early diagnosis of this disease entity, especially light-chain CA subtype, is crucial, as it portends a poorer prognosis. This review focuses on the clinical utility of the various imaging modalities in the diagnosis and differentiation of CA subtypes. This review also aims to highlight the key advances in each of the imaging modalities in the diagnosis and prognostication of CA.

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“…ECG can help by detecting pseudo infarct patterns and discordant left ventricular hypertrophy [15]. ECHO classically shows signs of left ventricular hypertrophy and apical sparing detected on the global longitudinal strain and valvular anomalies with thickening of the valves and interatrial septum [4,17,18]. MRI also has a role in completing the diagnostic study of a patient with suspected CA; it is, however, a sophisticated imaging technique, not usually practiced in many hospitals, and of long duration, as machine occupation time, limiting the number of studies that can be performed per day [19].…”

Section: Discussionmentioning

confidence: 99%

“…It leads in many cases, to postural hypotension and electrocardiogram (ECG) changes, mainly low voltage [14,15]. Echocardiography (ECHO) shows bilateral atrial dilatation, left ventricular hypertrophy, and diastolic dysfunction [16][17][18]. There is a reduction of the global longitudinal strain, and bull's eye mapping demonstrates an apical sparing, which does not exist in patients with hypertension or hypertrophic cardiomyopathy [18].…”

Section: Introductionmentioning

confidence: 99%

Census of Cardiac Uptake on Routine Bone Scintigraphy, a Methodology to Assess the Prevalence of the TTR Amyloidosis

Khoury¹,

Nasr²,

Chéhadé³

2022

JICOA

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Objective: Transthyretin cardiac amyloidosis is a rapidly progressive disease, remains underdiagnosed, and has long been considered a rare disease. Diagnosis decision making cannot be based on echography and MRI findings alone because they lack accuracy. However, it requires invasive test of myocardial or fat pad biopsies. Thus, the diagnosis is challenging, and the non-invasive scintigraphic technique using bone-seeking radiopharmaceuticals has become a cornerstone in the workup revealing a myocardial uptake. Our work consists of a single institution retrospective study aiming to estimate the bone scintigraphies, and the prevalence of the transthyretin cardiac amyloidosis in our population. Methods: We have carried out a census of the incidental cardiac uptake on routine bone scintigraphy in 2211 consecutive patients enrolled between 2009 and 2020, mostly performed for oncologic purposes. The visual analysis of the scintigraphic images classifies the cardiac uptake into 3 levels of gradation and evokes the diagnosis of the TTR cardiac amyloidosis in grades 2 and 3. Results: Different grades of myocardial uptake were observed in 1.37 % of all patients. Prevalence of uptake was 0.37% in the 50th, increased dramatically at the 60th (2.49%), and reached 4% above the age of 80. The diagnostic grades 2 and 3 cardiac uptakes were identified in 5 patients (0.23% of overall patients) ranging between 56- and 91-y-old. Our results concord with the trend of disease increases with age. Conclusion: The careful analysis of the bone scintigraphy of all incoming adult patients should allow to make the diagnosis of the TTR cardiac amyloidosis at a preclinical stage and establish new effective treatments. Our results provide an estimate of the number of patients that could be diagnosed and improve the awareness of the corresponding prevalence in our population. In this way, multicentric studies should be implemented by enrolling large cohorts of bone scintigraphy cases.

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Cardiac Amyloidosis Shows Decreased Diastolic Function as Assessed by Echocardiographic Parameterized Diastolic Filling

Cited by 8 publications

References 24 publications

Research trends and hotspots evolution of cardiac amyloidosis: a bibliometric analysis from 2000 to 2022

Research trends and hotspots evolution of cardiac amyloidosis: a bibliometric analysis from 2000 to 2022

The Role of Multi-modality Imaging in the Diagnosis of Cardiac Amyloidosis: A Focused Update

Census of Cardiac Uptake on Routine Bone Scintigraphy, a Methodology to Assess the Prevalence of the TTR Amyloidosis

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