Cardenolides from the stem bark of Salacia staudtiana

Kamtcha, Duplex Wetadieu; Téné, Mathieu; Bedane, Kibrom Gebreheiwot; Knauer, Lena; Strohmann, Carsten; Tane, Pierre; Kusari, Souvik; Spiteller, Michael

doi:10.1016/j.fitote.2018.04.008

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…An ethanolic extract of Polypodium niponicum (Chinese name "shuilonggu") contained two steroids, shuilongguine II (232) and shuilongguine III (233) [161]. Viridin-related B-norsteroids, B-norviridiol lactone (234) and B-norviridin enol (235), both with unique unprecedented carbon skeletons, were isolated from Hymenoscyphus pseudoalbidus, a fungus responsible for ash dieback.…”

Section: B-norsteroids and Triterpenoids Derived From Terrestrial Sou...mentioning

confidence: 99%

“…Cardenolide (350), with distinct antibacterial activity, was isolated from the seeds of the Cameroonian medicinal plant Salacia staudtiana [233]. Neoabiestrines D (351), E (352), and F (353) are cytotoxic rearranged lanostanes from Abies recurvata, with compound 352 showing potent antiproliferative effects [234].…”

Section: C-norsteroids Derived From Plant Speciesmentioning

confidence: 99%

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Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Dembitsky

2024

Biomedicines

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The main focus of this review is to introduce readers to the fascinating class of lipid molecules known as norsteroids, exploring their distribution across various biotopes and their biological activities. The review provides an in-depth analysis of various modified steroids, including A, B, C, and D-norsteroids, each characterized by distinct structural alterations. These modifications, which range from the removal of specific methyl groups to changes in the steroid core, result in unique molecular architectures that significantly impact their biological activity and therapeutic potential. The discussion on A, B, C, and D-norsteroids sheds light on their unique configurations and how these structural modifications influence their pharmacological properties. The review also presents examples from natural sources that produce a diverse array of steroids with distinct structures, including the aforementioned A, B, C, and D-nor variants. These compounds are sourced from marine organisms like sponges, soft corals, and starfish, as well as terrestrial entities such as plants, fungi, and bacteria. The exploration of these steroids encompasses their biosynthesis, ecological significance, and potential medical applications, highlighting a crucial area of interest in pharmacology and natural product chemistry. The review emphasizes the importance of researching these steroids for drug development, particularly in addressing diseases where conventional medications are inadequate or for conditions lacking sufficient therapeutic options. Examples of norsteroid synthesis are provided to illustrate the practical applications of this research.

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Section: B-norsteroids and Triterpenoids Derived From Terrestrial Sou...mentioning

confidence: 99%

Section: C-norsteroids Derived From Plant Speciesmentioning

confidence: 99%

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Dembitsky

2024

Biomedicines

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“…Cardenolide (350), with distinct antibacterial activity, was isolated from the seeds of the Cameroonian medicinal plant Salacia staudtiana [233]. Neoabiestrine D (351), E (352), and F (353) are cytotoxic rearranged lanostanes from Abies recurvata, with compound 352 showing potent antiproliferative effects [234].…”

Section: C-nor Steroids Derived From Plant Speciesmentioning

confidence: 99%

Naturally Occurring Nor-Steroids and Their Design and Pharmaceutical Application

Dembitsky

2024

Preprint

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The main focus of this review is to introduce readers to the fascinating class of lipid molecules known as norsteroids, exploring their distribution across various biotopes and their biological activities. The review provides an in-depth analysis of various modified steroids, including A, B, C, and D-norsteroids, each characterized by distinct structural alterations. These modifications, which range from the removal of specific methyl groups to changes in the steroid core, result in unique molecular architectures that significantly impact their biological activity and therapeutic potential. The discussion on A, B, C, and D-norsteroids sheds light on their unique configurations and how these structural modifications influence their pharmacological properties. The review also presents examples from natural sources that produce a diverse array of steroids with distinct structures, including the aforementioned A, B, C, and D-nor variants. These compounds, sourced from marine organisms like sponges, soft corals and starfish, as well as terrestrial entities such as plants, fungi, and bacteria. The exploration of these steroids encompasses their biosynthesis, ecological significance, and potential medical applications, highlighting a crucial area of interest in pharmacology and natural product chemistry. The review emphasizes the importance of researching these steroids for drug development, particularly in addressing diseases where conventional medications are inadequate or for conditions lacking sufficient therapeutic options. Examples of norsteroid synthesis are provided to illustrate the practical applications of this research.

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“…The following are available online, Table S1: Pentacyclic triterpenoids isolated from Celastraceae species (2001–2021) [ 257 , 258 , 259 , 260 , 261 , 262 , 263 , 264 , 265 , 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 ,…”

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Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

et al. 2022

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The Celastraceae family comprises about 96 genera and more than 1.350 species, occurring mainly in tropical and subtropical regions of the world. The species of this family stand out as important plant sources of triterpenes, both in terms of abundance and structural diversity. Triterpenoids found in Celastraceae species display mainly lupane, ursane, oleanane, and friedelane skeletons, exhibiting a wide range of biological activities such as antiviral, antimicrobial, analgesic, anti-inflammatory, and cytotoxic against various tumor cell lines. This review aimed to document all triterpenes isolated from different botanical parts of species of the Celastraceae family covering 2001 to 2021. Furthermore, a compilation of their 13C-NMR data was carried out to help characterize compounds in future investigations. A total of 504 pentacyclic triterpenes were compiled and distinguished as 29 aromatic, 50 dimers, 103 friedelanes, 89 lupanes, 102 oleananes, 22 quinonemethides, 88 ursanes and 21 classified as others.

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Cardenolides from the stem bark of Salacia staudtiana

Cited by 7 publications

References 20 publications

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

Naturally Occurring Nor-Steroids and Their Design and Pharmaceutical Application

Pentacyclic Triterpenoids Isolated from Celastraceae: A Focus in the 13C-NMR Data

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