Cardamonin, a schistosomicidal chalcone from Piper aduncum L. (Piperaceae) that inhibits Schistosoma mansoni ATP diphosphohydrolase

Abstract

This report provides evidence for the in vitro schistosomicidal activity of cardamonin and demonstrated, for the first time, that this chalcone is highly effective in inhibiting S. mansoni ATP diphosphohydrolase, opening the route to further studies of chalcones as prototypes for new S. mansoni ATP diphosphohydrolase inhibitors.

Flavonoids and Sesquiterpene Lactones from Artemisia absinthium and Tanacetum parthenium against Schistosoma mansoni Worms

“…Thus, a pattern consisting of a combination of changes in the surface morphology was detected and correlated to the death of the adult worms. These pronounced changes in the aspect of tubercles, which often appeared collapsed and disrupted, were similar to those reported in studies with other isolated natural compounds, such as piplartine, (+)-limonene epoxide, cardamonin, and licoflavone B [2, 3, 8, 21, 22]. …”

“…In this scenario, the search for bioactive plant extracts, which can be used as anthelmintic, has received considerable attention [2, 6, 8, 11]. Among medicinal plants, A. absinthium and T. parthenium have shown to be good sources for providing biologically activity compounds against parasites [13, 14, 16].…”

“…Among medicinal plants, A. absinthium and T. parthenium have shown to be good sources for providing biologically activity compounds against parasites [13, 14, 16]. Then, as part of our search for schistosomicidal molecules from Brazilian plants [2, 3, 8, 11], we performed, for the first time, the in vitro schistosomicidal assay of the crude extracts of A. absinthium (AA) and T. parthenium (TP).…”

“…According to World Health Organization, of the 78 countries considered endemic for schistosomiasis, only 52 countries have populations requiring preventive chemotherapy [1, 2]. In Brazil, eight million people, from endemic regions stretching from the north to the south-east of the country, mainly in the Minas Gerais State, are infected with this chronic debilitating disease [2, 3]. …”

“…In this regard, the search for antiparasitic compounds from natural sources, especially medicinal plants, has intensified [2, 7–9]. Several plants of the family Asteraceae have shown promising in vitro schistosomicidal activity [10, 11].…”