Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre‐diabetic women: a randomized double‐blind clinical trial

Kazemi, Shiva; Fatemeh, Yaghooblou; Siassi, Fereydoun; Foroushani, Abbas Rahimi; Ghavipour, Mahsa; Koohdani, Fariba; Sotoudeh, Gity

doi:10.1002/jsfa.8414

Cited by 41 publications

(30 citation statements)

References 32 publications

(72 reference statements)

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“…A significant decrease in concentration of C‐reactive protein was seen by I. gabonensis (Ngondi et al, ), pomegranate (Hosseini et al, ), Palmaria palmata (Allsopp et al, ), puerh tea (Chu et al, ; Yang et al, ), Opuntia ficus‐indica (Godard et al, ), cardamom (Kazemi et al, ), Salba‐chia ( S. hispanica L.; Vuksan et al, ), and the combination red orange, grapefruit, sweet orange, and guarana (Dallas et al, ; Figure ).…”

Section: Discussionmentioning

confidence: 99%

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Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Payab

Hasani‐Ranjbar

Shahbal

et al. 2019

Phytotherapy Research

100

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Obesity is a medical situation in which excess body fat has gathered because of imbalance between energy intake and energy expenditure. In spite of the fact that the variety of studies are available for obesity treatment and management, its “globesity” still remains a big challenge all over the world. The current systematic review and meta‐analysis aimed to evaluate the efficacy, safety, and mechanisms of effective herbal medicines in the management and treatment of obesity and metabolic syndrome in human. We systematically searched all relevant clinical trials via Web of Science, Scopus, PubMed, and the Cochrane database to assess the effects of raw or refined products derived from plants or parts of plants on obesity and metabolic syndrome in overweight and obesity adult subjects. All studies conducted by the end of May 2019 were considered in the systematic review. Data were extracted independently by two experts. The quality assessment was assessed using Consolidated Standards of Reporting Trials checklist. The main outcomes were anthropometric indices and metabolic syndrome components. Pooled effect of herbal medicines on obesity and metabolic syndrome were presented as standardized mean difference (SMD) and 95% confidence interval (CI). A total of 279 relevant clinical trials were included. Herbals containing green tea, Phaseolus vulgaris, Garcinia cambogia, Nigella sativa, puerh tea, Irvingia gabonensis, and Caralluma fimbriata and their active ingredients were found to be effective in the management of obesity and metabolic syndrome. In addition, C. fimbriata, flaxseed, spinach, and fenugreek were able to reduce appetite. Meta‐analysis showed that intake of green tea resulted in a significant improvement in weight ([SMD]: −0.75 [−1.18, −0.319]), body mass index ([SMD]: −1.2 [−1.82, −0.57]), waist circumference ([SMD]: −1.71 [−2.66, −0.77]), hip circumference ([SMD]: −0.42 [−1.02, −0.19]), and total cholesterol, ([SMD]: −0.43 [−0.77, −0.09]). In addition, the intake of P. vulgaris and N. sativa resulted in a significant improvement in weight ([SMD]: −0.88, 95 % CI: [−1.13, −0.63]) and triglyceride ([SMD]: −1.67, 95 % CI: [−2.54, −0.79]), respectively. High quality trials are still needed to firmly establish the clinical efficacy of the plants in obesity and metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

“…, pomegranate(Hosseini et al, 2016), Palmaria palmata(Allsopp et al, 2016), puerh tea(Chu et al, 2011;Yang et al, 2014), Opuntia ficus-indica(Godard et al, 2010), cardamom(Kazemi et al, 2017), Salba-chia (S. hispanica L.;Vuksan et al, 2017), and the combination red orange, grapefruit, sweet orange, and guarana(Dallas et al, 2014; Figure 2).…”

mentioning

confidence: 99%

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Payab

Hasani‐Ranjbar

Shahbal

et al. 2019

Phytotherapy Research

100

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“…Han and Parker (2017) reported that cardamom essential oil has potential anti-inflammatory and immunomodulatory properties. Recently, Kazemi et al (2017) claimed that cardamom improved inflammatory indices and oxidative stress in pre-diabetic women. However, eugenol and acetyleugenol are the major compounds of clove which displayed potential immunomodulatory/anti-inflammatory effects.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Bioactives in spices, and spice oleoresins: Phytochemicals and their beneficial effects in food preservation and health promotion

Shahidi¹,

Hossain²

2018

JFB

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Spices have broadly been used as food flavoring and folk medicine since ancient times. Numerous phytochemicals have been identified in spices, namely thymol (ajowan and thyme), anethole (aniseed), piperine (black pepper), capsaicin (capsicum), cinnamaldehyde (cinnamon), eugenol (clove), linalool (coriander), sabinene (curry leaf), limonene (dill seed), estragole (fennel seed), allicin (garlic), gingerol (ginger), safranal (saffron), and curcumin (turmeric), among others. The antioxidants in spices are very effective and also render anti-mutagenic, cardioprotective, anti-inflammatory, and anti-cancer properties. Apart from their antioxidant efficacy, spices, particularly their essential oils possess strong antimicrobial activity against bacteria, fungi, yeasts, and microbial toxins synthesis. In this contribution, a summary of the most relevant and recent findings on phytochemical composition and antioxidant properties of spices has been compiled and discussed. The content of phenolic acids, flavonoids, tannins, glycosides, steroids, and terpenoids in different spices are summarized. In addition, the beneficial effects of spices in food preservation and in health promotion and disease risk reduction are briefly described.

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“…This spice is a good source of polyphenolic compounds such as quercetin, kaempferol, luteolin, pelargonidin, gallic acid, caffeic acid, and limonene, which have antioxidant properties (Deepa, Ayesha, Nishtha, & Thankamani, 2013;Nair & Kutty, 2004;Sharma, Sharma, & Kaur, 2011). Therapeutic effects of cardamom have been found in diabetes (Azimi, Ghiasvand, Feizi, Hariri, & Abbasi, 2014;El-Yamani, 2011), cancer (Kaefer & Milner, 2008), inflammation (Kazemi et al, 2017), gastrointestinal disorders (Jamal, Javed, Aslam, & Jafri, 2006), and hypertension (Verma, Jain, & Katewa, 2009). Recently, evidence from a number of clinical studies (Aghasi et al, 2019;Azimi et al, 2014;Daneshi-Maskooni et al, 2019;Fatemeh et al, 2017;Verma, Jain, & Singh, 2012) focused on the beneficial effects of cardamom on circulating lipids and lipoproteins; however, the existing trials yielded inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Effects of cardamom supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled clinical trials

Shekarchizadeh-Esfahani

Arab

Ghaedi

et al. 2019

Phytotherapy Research

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Cardiovascular disease is a highly prevalent issue worldwide and one of its main manifestations, dyslipidemia, needs more attention. Recent studies have suggested that cardamom has favorable effects beyond lipid lowering, but the result are contradictory. Our objective was to conduct a systematic review and meta‐analysis on randomized controlled trials (RCTs) that assessed the effect of cardamom on lipids. The search included PubMed, Scopus, ISI Web of Science, Google Scholar, and the Cochrane library (up to March, 2019) to identify RCTs investigating the effects of cardamom supplementation on serum lipid parameters. Weighted mean differences (WMDs) were pooled using a random‐effect model. Meta‐analysis of data from five eligible RCTs showed that cardamom supplementation did not significantly change the concentrations of total cholesterol (WMD: −6.11 mg/dl, 95% CI [−13.06, 0.83], I2 = 0.0%), low‐density lipoprotein cholesterol (WMD: −4.31 mg/dl, 95% CI [−9.75, 1.13], I2 = 0.0%), or high‐density lipoprotein cholesterol (WMD: 1.75 mg/dl, 95% CI [−1.95 to 5.46], I2 = 71.4%). However, a significant reduction was observed in serum triglyceride (TG; WMD: −20.55 mg/dl, 95% CI [−32.48, −8.63], I2 = 0.0%) levels after cardamom supplementation. Cardamom might be able to change TG, but for confirming the results, more studies exclusively on dyslipidemia patients and considering the intake of lipid lowering agents as exclusion criteria are necessary.

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Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre‐diabetic women: a randomized double‐blind clinical trial

Cited by 41 publications

References 32 publications

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Effect of the herbal medicines in obesity and metabolic syndrome: A systematic review and meta‐analysis of clinical trials

Bioactives in spices, and spice oleoresins: Phytochemicals and their beneficial effects in food preservation and health promotion

Effects of cardamom supplementation on lipid profile: A systematic review and meta‐analysis of randomized controlled clinical trials

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