CARD15 and TLR4 polymorphisms in atopic bronchial asthma

Association between theTLR4 +896A>G(Asp299Gly) Polymorphism and Asthma: A Systematic Review and Meta-Analysis

“…A total of 11 relevant studies (10,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) investigating the TLR4 þ896A>G polymorphism and asthma for meta-analysis were identified. However, a Singaporean Chinese population (20) and a Japanese population (21) were monomorphic at site and were excluded from meta-analysis.…”

“…Therefore, a total of nine case-control studies were included in the meta-analysis with a total of 3602 unique subjects (n ¼ 1838 asthma cases and 1764 controls). Six of nine study populations were of the broadly categorized European ethnicity (10,15,16,(22)(23)(24). The remaining study populations were of Chinese (19), Egyptian (17), and Tunisian (18) ethnicities, considered as non-European in the analysis.…”

Role of TLR4 C>1196T (Thr399Ile) and TLR4 A>896G (Asp299Gly) polymorphisms in a North Indian population with asthma: a case‐control study

“…However, in Swedish children, TLR4 (Asp299Gly) is associated with fourfold higher prevalence in school‐aged children (OR = 4.5, 95% CI 1.1–17.4) (Bottcher et al ., ). In a Russian population, study conducted on 283 atopic patients with bronchial asthma and 227 healthy donors, a strong association was found between Asp299Gly and asthma severity with OR = 2.12, 95% CI (1.08–4.18) (Voronko et al ., ). In contrast, in a study conducted on Singaporean Chinese subjects, neither the Asp299Gly nor the Thr399Ile polymorphism was found, which was confirmed by DNA sequencing (Liang et al ., ).…”

“…Studies conducted on Turkish, Danish and Russian populations revealed a strong association between TLR4 and atopic bronchial asthma (Sac ßkesen et al, 2005;Kerkhof et al, 2010;Voronko et al, 2011), while other studies on Finnish, Tunisian, Norwegian, Chinese and Caucasian populations showed lack of association with the disease (Adjers et al, 2005;Smit et al, 2007;Lachheb et al, 2008;Bjornvold et al, 2009;Zhang et al, 2011;Hussein et al, 2012).…”

Atopic eczema: a disease modulated by gene and environment

“…SNPs of NOD1 (rs2907748, rs2907749, and rs2075822) as well as a NOD2 variant (R702W)are significantly associated with AE and asthma. Moreover, NOD2deficient mice have impaired clearance of S. aureus after subcutaneous or intraperitoneal infection (74)(75)(76). Whether or not NOD2 SNPs are correlated with increased susceptibility to epicutaneous S. aureus infections in patients with AE needs to be addressed.…”