Carcinostatic activity of 4-hydroxy-2-pent-en-1-al against transplantable murine tumour lines

Investigation on Trichothecene-Stimulated Lipid Peroxidation and Toxic Effects of Trichothecenes in Animals

“…However, an experiment in vitro represents very different conditions from those in the liver of living animals. The compounds which are generated by lipid peroxides are removed from the liver by the circulating blood, and some of them react very quickly with thiol groups (Conroy et al 1975). According to Esterbauer (1982), the oxidation of arachidonic, linoleic and linoleinic acids produces n-hexanal and 4-hydroxynonenal as major compounds.…”

Role of aldehydes in carcinogenesis

“…Another related aldehyde, trans-4-hydroxypent-2-enal has carcinostatic activity against the transplantable murine tumor lines (40).…”

4, 6-0-Benzylidene-D-glucopyranose (BG) in the treatment of solid malignant tumours, an extended phase I study

“…The anti-tumour effects of various aldehydes have often been reported (Osato, 1950;Conroy et al, 1975;Sessa et al, 1977;Derin et al, 1978;Egyud & Gyorgyi, 1968). Among them, the effects of benzaldehyde (BA), originally extracted from fig fruit, on experimentally induced carcinomas (Takeuchi et al, 1978;Petterson et al, 1985;Soga et al, 1985), on cultured cell lines (Zundel et al, 1975;Miyakawa et al, 1979;Watanuki & Sakaguchi, 1980;Watanuki & Sakaguchi, 1981;Isida et al, 1983;Nambata et al, 1982;Petterson et al, 1983;Petterson et al, 1983;Petterson et al, 1985) and on advanced stage human carcinomas (Kochi et al, 1980;Kochi et al, 1985) have attracted considerable attention.…”