Carcinosarcoma of the uterus: A case report

Adachi, Yasushi; Nonogaki, Hirofumi; Minamiguchi, Sachiko; Li, Ming; Ikehara, Susumu

doi:10.3892/mco.2016.744

Cited by 10 publications

(7 citation statements)

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“…Carcinosarcoma is a malignant mixed Müllerian tumor, defined by the presence of high-grade malignant epithelial and mesenchymal components [ 17 ]. The mesenchymal component may be homologous or heterologous, the latter also including liposarcoma [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

A Case of Giant Mesenchymal Uterine Tumor: Lipoleiomyoma

et al. 2021

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Patient: Female, 66-year-old Final Diagnosis: Lipoleiomyoma Symptoms: Abdominal pain • pollakiuria and abnormal vaginal bleeding Medication: — Clinical Procedure: — Specialty: Obstetrics and Gynecology Objective: Rare disease Background: Uterine lipoleiomyoma is a rare benign tumor composed of varying proportions of smooth muscle fibers and mature adipocytes, without identification of hemorrhage, necrosis, or cyto-architectural atypia. It is part of the leiomyomas category, with an incidence of 0.03–0.2%. The pathogenesis of this lesional category is still unclear, but there are several theories that could explain the occurrence. Magnetic resonance imaging is the most useful diagnostic imaging method. There are a number of pathologies whose exclusion is necessary, with the differential diagnosis being made mainly based on microscopic examination and completed with immunohisto-chemical tests. Their treatment, when necessary, is surgical, with an excellent post-therapeutic evolution and prognosis. Case Report: We present the case of an elderly, postmenopausal patient who presented with abdominal pain, abnormal vaginal bleeding, and pollakiuria. The associated pathologies of the patient correspond to those mentioned in the literature, the particularities of the case being given by the large size of the tumor and the association with 2 other typical leiomyomas. Immunohistochemical markers used to exclude other diagnoses (desmin, h-caldesmon, S100, calretinin, MDM2, CD34) confirmed the diagnosis of uterine lipoleiomyoma. Because the patient was symptomatic and a large nodular mass was identified by ultrasound, surgical treatment was performed. Conclusions: Although it is a benign lesion with an excellent prognosis, the pathogenetic mechanisms are not fully known. Theories of pathogenesis range from misplacing embryonic adipocytes to connective tissue fatty degeneration, and further studies are needed to establish the origin of this lesion.

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Section: Discussionmentioning

confidence: 99%

A Case of Giant Mesenchymal Uterine Tumor: Lipoleiomyoma

et al. 2021

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“…1 Carcinosarcomas occur mainly in women~15-17 years after menopause with vaginal bleeding, abdominal pain and uterine enlargement and or polypoid mass in an older patient. 1,3,9 The symptom triad indicative of carcinosarcoma rather than endometrial adenocarcinoma include pain , severe vaginal bleeding and the passage of necrotic tissue per vaginum. 9 The diagnosis is most often made post hysterectomy on histopathological examination and immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 They make up to less than 5% of all uterine cancers. [1][2][3] It is a biphasic neoplasm comprising of both carcinomatous and sarcomatous components 2,4 and a poor prognosis. They mostly affect postmenopausal women and are managed surgically.…”

Section: Introductionmentioning

confidence: 99%

Carcinosarcoma of uterine corpus – A case report

Patil¹,

Aloorker

2021

JDPO

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Uterine carcinosarcomas comprise a distinct rare entity of uterine malignancy with a very aggressive nature and poor prognosis. They make up to less than 5% of all uterine cancers. We report a case of 45yr old lady who presented with the complain of vaginal bleeding since two months and was a known case of dysfunctional uterine bleeding. Postoperative histopathological examination of the hysterectomy specimen revealed the diagnosis of uterine carcinosarcoma.

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“…Carcinosarcoma of the uterus (UCS) (previously known as malignant mixed Müllerian tumors [MMMT]) are rare, aggressive tumors that account for 2–5% of all uterine malignancies ( Adachi et al, 2016 ). Despite its rarity, it is responsible for 15% of uterine cancer-related deaths.…”

Section: Introductionmentioning

confidence: 99%