Carcinosarcoma of the Urinary Bladder: A Case Report

Gupta, Limci; Elder, Jacqueline

doi:10.1100/tsw.2005.35

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…Unexplained synaptophysin expression has been reported in such cases, although chromogranin is negative (myogenin ± myoD1 are positive). Extensive sampling should be undertaken to exclude heterologous rhabdomyosarcomatous overgrowth in sarcomatoid carcinoma/carcinosarcoma 146,147 . The treatment for small cell carcinoma of bladder is usually systemic therapy, combined with local treatment to the bladder 134,148 …”

Section: Other Forms Of Divergent Differentiation and Other Carcinomamentioning

confidence: 99%

“…Extensive sampling should be undertaken to exclude heterologous rhabdomyosarcomatous overgrowth in sarcomatoid carcinoma ⁄ carcinosarcoma. 146,147 The treatment for small cell carcinoma of bladder is usually systemic therapy, combined with local treatment to the bladder. 134,148 large cell neuroendocrine carcinoma Large cell neuroendocrine carcinoma has been reported in the bladder but is very rare and a highly aggressive tumour.…”

Section: Verrucous Carcinoma and Warty Carcinomamentioning

confidence: 99%

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Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics

Shanks

Iczkowski

2009

Histopathology

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Conventional urothelial carcinoma accounts for most carcinomas of the urinary tract lining. However, neoplastic urothelium has the capacity to demonstrate enormous plasticity. A variety of unusual architectural patterns of urothelial carcinoma, such as the nested, microcystic and inverted variants, can be mistaken for reactive processes or benign tumours. Others such as the micropapillary, plasmacytoid and discohesive variants, can mimic metastatic tumour from other sites. The micropapillary variant in particular is more aggressive. In addition, urothelial carcinoma has a propensity to demonstrate divergent differentiation with glandular, squamous, small cell neuroendocrine, lymphoepithelioma-like, sarcomatoid or other elements. Pure squamous carcinoma or adenocarcinoma (the latter in particular) can be difficult to distinguish from contiguous or metastatic spread. Some variants have prognostic and potential therapeutic implications. Molecular genetic evidence has emerged recently supporting a close relationship between urothelial carcinoma and various divergent elements. Sarcomatoid carcinoma and its differential diagnosis with other spindle cell lesions of urinary tract will be covered in a separate review.

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Section: Other Forms Of Divergent Differentiation and Other Carcinomamentioning

confidence: 99%

Section: Verrucous Carcinoma and Warty Carcinomamentioning

confidence: 99%

Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics

Shanks

Iczkowski

2009

Histopathology

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“… 2 However, at 12 months after treatment, pelvic bone metastasis was developed. Given the radioresistant nature of carcinosarcoma and the rapidly regrowing tumor after primary surgery, 5 in our case, adjuvant CCRT was performed after primary surgery. Furthermore, we employed the VMAT technique for RT, which is known as one of the most developed RT techniques, in our case to spare normal tissue by maintaining the local control effect ( Fig.…”

Section: Discussionmentioning

confidence: 99%

A rare malignant periurethral carcinosarcoma with aggressive behavior: A case treated with a multimodal treatment approach

Lee

Kang

Kim

et al. 2021

Urology Case Reports

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Carcinosarcoma is an aggressive tumor that can develop in any organ but is rarely observed in the urinary tract. Given the radioresistant nature of carcinosarcoma and the rapidly regrowing tumor after primary surgery, carcinosarcomas that developed in the body showed poor outcomes regardless of aggressive management. However, the specific optimal treatment for periurethral carcinosarcoma remains unknown. The present study reports a rare case of periurethral carcinosarcoma with metastasis of the skull after receiving surgery for primary tumors with adjuvant concurrent chemoradiation therapy.

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Carcinosarcoma of the Urinary Bladder: A Case Report

Abstract: Carcinosarcomas are rare tumours containing both malignant mesenchymal and epithelial elements. This reports presents a 70-year-old man with carcinosarcoma of the urinary bladder, which is proven histologically.

Cited by 2 publications

References 6 publications

Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics

Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics

A rare malignant periurethral carcinosarcoma with aggressive behavior: A case treated with a multimodal treatment approach

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