Carcinosarcoma of the colon: Report of a case and review of the literature

Nakao, Atsunori; Sakagami, K; Uda, Masashi; Mitsuoka, Shintaro; Ito, Hisao

doi:10.1007/s005350050083

Cited by 32 publications

(19 citation statements)

References 7 publications

(6 reference statements)

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“…Three patients died of the tumor within a year. The best predictors of outcome in sarcomatoid carcinoma seem to be tumor location, size, invasion depth, and the clinical stage of the disease (1,(11)(12)(13). The majority of tumors in upper aerodigestive tract including esophagus and stomach have polypoid growth patterns and can be diagnosed early in their course, and accordingly, are associated with a relatively favorable prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Sarcomatoid Carcinoma of the Colon: A Case Report

et al. 2001

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Sarcomatoid carcinoma is a rare biphasic tumor characterized by a combination of malignant epithelial and mesenchymal cells. We report a rare case of sarcomatoid carcinoma of the colon. A 41-yr-old woman was hospitalized with a history of melena. Total colectomy was performed under the impression of colonic carcinoma. Histologically, the tumor was composed of differentiated adenocarcinoma in superficial portion and sarcomatoid spindle cells in deeper portion with a transitional area between the two portions. The sarcomatous areas revealed polygonal and spindle-shaped anaplastic malignant cells arranged in sheet, short fascicular or haphazard pattern. Immunohistochemically, tumor cells showed a positive immunoreaction for cytokeratin, epithelial membrane antigen, and vimentin. The histopathological and immunohistochemical transitions between the adenocarcinoma area and the spindle cell area suggested that the sarcomatous elements originated from the adenocarcinoma during tumor progression.

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Section: Discussionmentioning

confidence: 99%

“…To date, our search by computer (MED-LINE search) revealed only six cases of the colonic sarcomatoid carcinomas reported (1)(2)(3)(4)(5)(6). As a result, the natural history of these unusual tumors and the best methods of treatment thereof are uncertain.…”

Section: Introductionmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Colon: A Case Report

et al. 2001

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“…detected one in the descending colon in 1995, it has rarely been reported. Presently, including our case, 23 cases have been reported [1, 3, 4, 8-26] (Table 1). …”

Section: Discussionmentioning

confidence: 76%

“…A carcinosarcoma may develop in many different organs, but most commonly it is found in the head and neck area and in the female reproductive organs. In the gastrointestinal system, a carcinosarcoma occurs in the esophagus, stomach and biliary duct primarily, and it has been rarely reported in the large intestine [1, 3-5]. Generally, a carcinosarcoma has an aggressive behavior and a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Carcinosarcoma on Ascending Colon Found by Bowel Perforation: A Case Report

Shim¹,

Hong²,

Kim³

et al. 2010

J Korean Soc Coloproctol

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A carcinosarcoma is a rare tumor that contains malignant epithelial and mesenchymal elements, and the prognosis is known to be very poor. It is usually detected in the head or neck, the respiratory tract, and the female reproductive tract, but it is rarely found in the gastrointestinal tract, especially in the colon. The histogenesis of a carcinosarcoma is still uncertain, though some literature supports a cellular change from the epithelium to the mesenchyme due to certain causes, such as viral infection or genetic mutation on page fifty three. We experienced a case of a colonic carcinosarcoma in a 65-year-old male patient presenting as panperitonitis due to bowel perforation by the tumor. A right hemicolectomy with lymph node dissection was performed. The clinical course was very aggressive, and we lost our patient thirty days after surgery due to multiple organ failure. Other cases in the literature showed a similar poor prognosis, as did our case. Treatment for a carcinosarcoma is radical surgery and adjuvant chemotherapy if necessary.

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“…Later, Matsusaka et al showed that pseudosarcoma and sarcomatoid carcinoma were histologically and clinically the same conditions [20] . Moreover, several reports have used carcinosarcoma interchangeably to describe sarcomatoid carcinoma, further confusing the diagnosis and classification of these tumors [13,16,21] . Rosai J explained that when the sarcomatous component is mainly composed of spindle cells but still identifiable as epithelial ones morphologically or immunohistochemically, the diagnosis should be called sarcomatoid carcinoma [22] .…”

Section: Discussionmentioning

confidence: 99%