Carcinosarcoma of the Cervix: A Case Report

Abstract

Cervical carcinoma is the most common cause of mortality due to cancer in Nepal. Carcinosarcoma is a very rare subtype of cervical cancer which is characterized by the presence of both epithelial and mesenchymal malignant component. It constitutes less than 1% of cervical carcinoma. Due to the low occurrence of the disease, most of the data on treatment and prognosis are based on case reports and series. Here, we report a case of 69 years, female with cervical cancer (FIGO IIA2). Histopathological and immunohistochemical analysis of cervical biopsy initially showed primary adenosarcoma of the cervix. The tumor was non-responsive to primary treatment with concurrent chemoradiation. Later she was treated with abdominal hysterectomy and bilateral salpingo-oophorectomy. The final histopathology of the resected specimen showed a sarcomatous component along with carcinomatous changes in the endocervical glands favouring the diagnosis of carcinosarcoma of the cervix.

Cervical carcinosarcoma, report of some cases and a literature review

“…Cervical carcinosarcoma (CC) is a rare malignant tumor that belongs among the mixed Müllerian and Wolffian duct tumors. Neither treatment nor prognosis are entirely clear 1 . We report two cases.…”

Dramatic Radiographic Response of Pelvis-Filling Locally Advanced Cervical Cancer Treated With Radiation and Chemotherapy

“…Other case reports similar to the one presented have found mixed results regarding response to treatment. In a report by Bhagat et al, a 69-year-old female with International Federation of Gynecology and Obstetrics (FIGO) stage IIA2 cervical adenosarcoma with a lesion size of 9x 6x 5 cm occupying the cervix and lower uterine segment was non-responsive to chemoradiation [ 12 ]. This patient received 4800 cGy in 24 fractions of external beam radiation therapy and carboplatin weekly with a boost to the cervical mass of 1400 cGy in seven fractions [ 12 ].…”

“…This patient had a total abdominal hysterectomy and bilateral salpingo-oophorectomy with no evidence of recurrent disease four months after surgery. The authors recommend primary surgery for cases of carcinosarcoma, as many cases are unresponsive to chemoradiation [ 12 ].…”