Carcinosarcoma of skin

Leen, Eamonn; Saunders, Mike; Vollum, Dorothy I.; Keen, C. E.

doi:10.1111/j.1365-2559.1995.tb00200.x

Cited by 30 publications

(14 citation statements)

References 4 publications

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“…The immunophenotypic studies performed in the reported cases are summarized in Table . Immunophenotypically, the basaloid epithelial component marks as expected, with immunoreactivity for cytokeratins, p63, bcl‐2, Ber‐EP4, variable EMA, and negative for mesenchymal and melanocytic markers.…”

Section: Discussionmentioning

confidence: 56%

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Cutaneous basal cell carcinosarcoma: case report and literature review

et al. 2015

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Carcinosarcomas are malignant neoplasms with biphasic carcinomatous and sarcomatous or sarcoma-like components. In general, the sarcomatous component is accepted to be the result of divergent mesenchymal differentiation of the epithelial component. Although well characterized in some anatomic locations (e.g. uterus, upper aerodigestive tract and lung), carcinosarcomas of the skin are rare. Reported epithelial components include squamous, adnexal, neuroendocrine and basaloid. Including this case, only 47 cases of primary cutaneous basal cell carcinosarcoma have been reported in the literature to date. We performed an extensive immunophenotypic evaluation in our case, which confirmed the previously reported coexpression of p53 in both components, and revealed a hitherto unreported coexpression of p16 and p63. Additionally, this report reviews the clinical, pathologic, immunophenotypic characteristics and outcomes of the basal cell carcinosarcomas reported in the literature, in order to emphasize the overall uniform characteristics and clinical behavior of this neoplasm.

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Section: Discussionmentioning

confidence: 56%

“…In the reported cases, the epithelial component has been predominantly squamous cell and BCCs, and less frequently adnexal and Merkel cell carcinomas . Including this case, 47 cases of basal cell carcinosarcomas have been reported …”

Section: Discussionmentioning

confidence: 82%

Cutaneous basal cell carcinosarcoma: case report and literature review

et al. 2015

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“…Primary cutaneous carcinosarcoma is extremely rare. 28 These tumors have also been termed e4 | www.amjdermatopathology.com ''biphasic sarcomatoid carcinomas'' because both epithelial and mesenchymal elements must be evident. To make a diagnosis of carcinosarcoma, neoplastic epithelial cells generally show continuity with the skin surface and only the epithelial component stains positive for keratins.…”

Section: Discussionmentioning

confidence: 98%

Rhabdomyosarcoma of the Skin Resembling Carcinosarcoma: Report of a Case and Literature Review

Scatena¹,

Massi²,

Franchi³

et al. 2012

The American Journal of Dermatopathology

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Rhabdomyosarcomas (RMSs) are soft tissue sarcomas with skeletal muscle differentiation. Cutaneous RMSs are exceedingly rare, and in most cases, they represent metastatic disease or the dermal involvement by a tumor arising in the underlying soft tissues. We herein report the case of a 41-year-old man who developed a cutaneous swelling of the right nasal orbital angle. An initial incisional biopsy showed cytokeratin-positive atypical spindle cells forming long and intersecting fascicles, thus the case was diagnosed as carcinosarcoma. In the subsequent excisional biopsy, the skeletal myogenic differentiation of the tumor cells infiltrating the dermis and subcutis was demonstrated by morphology (presence of rhabdomyoblasts), immunohistochemistry (positivity for desmin, myogenin, myoglobin, and actins), and electron microscopy (evidence of rudimentary sarcomeric structures). A final diagnosis of primary cutaneous RMS was made. The patient was subjected to postoperative radiation and chemotherapy, but after 4 months, the patient developed a tumor recurrence followed by distant metastases and death. Review of the literature reveals that RMSs of the skin are often underrecognized and display peculiar clinical features in comparison with their more common soft tissue counterpart.

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“…1,4,8,11,20,21,29,34,[39][40][41]45,[51][52][53] The most common single epithelial component is either basal cell carcinoma (BCC) (6 cases 11,29,41,[51][52][53] or squamous cell carcinoma (SCC) (6 cases 1,39,40,53 ). The remaining cases arose in association with mixed epidermal carcinoma, 11 combined epidermal and adnexal carcinoma, 20,45 eccrine spiradenocarcinoma, 21,34 eccrine porocarcinoma, 40 and Merkel cell carcinoma 8 (Table 1).…”

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confidence: 99%

Sarcomatoid Basal Cell Carcinoma—Predilection for Osteosarcomatous Differentiation

Menamin

Goh

Poblet

et al. 2006

American Journal of Surgical Pathology

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Primary cutaneous carcinomas rarely show heterologous malignant mesenchymal differentiation. We report 11 cases of sarcomatoid basal cell carcinoma (BCC) with osteosarcomatous differentiation. The patients (7 men and 4 women) ranged in age from 61 to 92 years (median 75 y). The tumors presented as exophytic nodules (0.3 to 7 cm) on the head (n=6), upper limb (n=3), and lower limb (n=2). All lesions were completely excised. Seven patients were alive without evidence of disease (follow-up interval 5 to 24 mo) and 1 patient died of unrelated causes at 7 months without evidence of disease. On histology, the tumors were dermal in location with 2 cases showing focal subcutaneous involvement. Ten tumors were well-circumscribed and 1 tumor showed focally infiltrative edges. Ten tumors revealed conventional BCC associated with varying proportions of osteosarcomatous and undifferentiated sarcomatous stroma. Transition from neoplastic epithelial to mesenchymal cells was seen in 8 cases. One case showed a purely osteoclastic giant cell rich malignant mesenchyme, interpreted as representing early stages of osteosarcomatous transformation. Previously unreported in sarcomatoid BCC, the mesenchymal component of another two cases displayed predominant malignant giant cell tumor like areas and 1 further case disclosed areas reminiscent of telangiectatic osteosarcoma. Pancytokeratins (AE1/3 and MNF116) and smooth muscle actin stained occasional undifferentiated sarcomatous cells in 2 and 3 tumors, respectively. MNF116 and EMA were focally positive in osteosarcomatous tumor cells of 1 case. Although the follow-up interval is short, our data suggest an excellent prognosis for polypoid and exophytic sarcomatoid BCC after complete surgical resection.

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Carcinosarcoma of skin

Cited by 30 publications

References 4 publications

Cutaneous basal cell carcinosarcoma: case report and literature review

Cutaneous basal cell carcinosarcoma: case report and literature review

Rhabdomyosarcoma of the Skin Resembling Carcinosarcoma: Report of a Case and Literature Review

Sarcomatoid Basal Cell Carcinoma—Predilection for Osteosarcomatous Differentiation

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