Carcinosarcoma of parotid gland (malignant mixed tumor)

Duan, Feng; Fidele, Nyimi Bushabu; Agustin, Mansthumba Milolo; Guan, Jian; Bourleyi, Sekele Isouradi; Augustin, Lamwe; Olivier, Ngueji Kakubu

doi:10.4103/2231-0746.175757

Cited by 13 publications

(6 citation statements)

References 8 publications

(10 reference statements)

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“…The median age of patients in our study was 66 years, and 43% of patients were diagnosed between the ages of 50 and 70 years. Some studies report that carcinosarcoma has a predilection to occur in males while others report no sex predominance 14–16 . Our study demonstrated a slightly higher frequency in males (59% vs 41%).…”

Section: Discussioncontrasting

confidence: 50%

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Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands

Talwar

Patel

Tam

et al. 2022

Otolaryngol.--head neck surg.

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Objective Carcinosarcoma of the salivary gland is a rare malignant biphasic tumor. The present study investigates the epidemiology and clinical behavior of carcinosarcoma of the major salivary glands using the National Cancer Database (NCDB). Study Design Historical cohort study. Setting NCDB. Methods All tumors were selected between 2004 and 2018. Patient demographics, tumor characteristics, treatments, and survival were analyzed. Cox regression analysis was performed in surgically treated patients. Results We identified 154 patients in the NCDB with carcinosarcoma of the salivary gland. Median age at diagnosis was 66 years (interquartile range, 55-76). Most patients were male (n = 92, 60%). The majority of tumors were in the parotid (n = 122, 79%), followed by submandibular gland (n = 21, 14%). The majority were high grade (n = 93, 95%), and a significant portion had locally advanced disease (pT3-4; n = 65, 62%). Nodal disease was present in more than one-third (n = 35, 36%). The most common treatment was surgery with adjuvant radiotherapy (n = 75, 49%). With a median follow-up of 36 months, the 3-year overall survival was 57.6% (95% CI, 48.7%-68.0%). In univariable analysis, advanced pT stage, pN+ disease, and positive margins were associated with worse survival. In multivariable analysis, age (hazard ratio, 1.02; 95% CI, 1.01-1.04; P = .03) and pT stage (hazard ratio, 2.51; 95% CI, 1.27-4.95; P = .008) remained significant. Conclusion Carcinosarcoma is a rare salivary gland tumor that frequently presents at a locally advanced stage. Despite multimodality treatments, the outcomes are poor. In the absence of clinical trial data, these data from the NCDB could guide clinicians in the management of this rare disease.

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Section: Discussioncontrasting

confidence: 50%

“…Some studies report that carcinosarcoma has a predilection to occur in males while others report no sex predominance. [14][15][16] Our study demonstrated a slightly higher frequency in males (59% vs 41%). The most common reported site of involvement for carcinosarcoma is the parotid gland (65%), followed by submandibular glands (19%).…”

Section: Discussionmentioning

confidence: 42%

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands

Talwar

Patel

Tam

et al. 2022

Otolaryngol.--head neck surg.

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“…The sarcomatous areas had a higher mean fractional allelic loss as compared to the carcinomatous areas suggesting additional mutations in those areas [13]. Katsakhyan et al reported a case of carcinosarcoma harboring PLAG1 translocation with an adjacent PA with an HMGA2 translocation [15]. As these translocations are mutually exclusive, it was concluded that the carcinosarcoma most likely came from another PA with PLAG1 mutation or originated de novo, thereby suggesting that the presence of PA is not conclusive of carcinosarcoma ex pleomorphic adenoma.…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of Parotid Gland: An extremely rare malignancy with an unusual carcinomatous component- A case report with review of literature

Jain

Abdelwahed

Chavarria

et al. 2023

Preprint

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Background Carcinosarcoma of the parotid gland is an extremely rare malignancy comprising of 0.04-0.16% of all salivary gland tumors. They consist of distinct carcinomatous and sarcomatous components and may arise de novo or from a preexisting pleomorphic adenoma. Methods and results Herein we present a case of an 80-year-old female who presented with progressively increasing left facial swelling over 6 weeks. Magnetic Resonance Imagining revealed a mass (3.4 cm) in the parotid gland with a predominant cystic/necrotic component. The cytology was atypical (Milan3) and a total parotidectomy and selective lymph node dissection was done. The resection showed extensive necrosis with high grade sarcomatous (chondrosarcoma) areas. The epithelial component was adenoid cystic carcinoma with perineural invasion. The patient is currently undergoing radiotherapy of the tumor bed and skull base due to propensity of perineural invasion of the adenoid cystic component. The most common carcinomas in carcinosarcomas of salivary glands are adenocarcinoma and squamous cell carcinoma. Conclusion This is the first case of an adenoid cystic carcinoma with chondrosarcoma to the best of our knowledge. Carcinosarcoma is a high-grade aggressive lesion with a poor prognosis and should be treated aggressively. More studies are needed to understand the origin of these tumors.

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“…2,4 In general, radical surgical exploration coupled with high dosage chemotherapy coupled with radiation are necessary for treatment. However, even with this aggressive regimen disease reoccurs in about 66% of patients, with metastatic dissemination in about 50% 8,9 (Table 1). Interestingly, the lungs seem to be the most common site of dissemination, but this was not seen in the present case.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Parotid Carcinosarcoma in an Asymptomatic Patient

Mansour

Mangaonkar

Kota

2016

Journal of Investigative Medicine High Impact Case Reports

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In this article, we present the case of a 52-year-old male with a history of parotid carcinosarcoma with initial diagnosis being 18 months prior. Initial treatment included a combination of gamma knife surgery coupled with high dosage chemotherapy and X-ray radiation therapy. At the time of follow-up, the patient presented with no complaints and had a nearly normal physical exam with the exception of some facial nerve weakness on the same side as the initial surgery. Despite being asymptomatic, the patient had a significant progression of disease that was manifested with intracranial lesions, multiple pathologic fractures, and a dramatic increase in overall tumor burden. Ultimately, the patient decided to pursue comfort measures only and succumbed to the disease peacefully soon thereafter.

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Carcinosarcoma of parotid gland (malignant mixed tumor)

Cited by 13 publications

References 8 publications

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands

Carcinosarcoma of Parotid Gland: An extremely rare malignancy with an unusual carcinomatous component- A case report with review of literature

Recurrent Parotid Carcinosarcoma in an Asymptomatic Patient

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