Carcinomes sarcomatoïdes du poumon : étude rétrospective de 28 cas

Zehani, Alia; Ayadi-Kaddour, A.; Marghli, A.; Maamouri, H.; Kassar, Lamia; Kilani, T.; Mezni, Faouzi El

doi:10.1016/j.annpat.2013.12.001

Cited by 14 publications

(9 citation statements)

References 18 publications

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“…For limited-stage PSCs, surgical resection is an effective treatment and provides adequate local control 22 . However, for metastatic PSC, platinum-based chemotherapy is commonly used for treatment as in other non-small cell lung cancer, although the efficacy is not ideal.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance and Next-Generation Sequencing of Chinese Pulmonary Sarcomatoid Carcinoma

Wang

Ren

et al. 2017

Sci Rep

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Pulmonary Sarcomatoid Carcinoma (PSC) constitutes a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with a poor prognosis. In this study, a group of 7 patients with PSC was studied. Microscope analysis of all 7 cases revealed a pleomorphic carcinoma subtype. Moreover, 5 cases (71.4%) were composed entirely of malignant sarcomatoid-like elements, and 2 cases (28.6%) were composed of malignant sarcomatoid-like elements and at least 10% adenocarcinoma-like elements. Immunohistochemically, the PSC components of all 7 cases were positive for vimentin and cytokeratins, including cytokeratin (CK) and cytokeratin 7 (CK7). Next-Generation Sequencing (NGS) was performed, and a total of 136 putative somatic variants and one gene fusion were identified, of which 16 variants were considered hot spot mutations, including the genes EGFR, EML4-ALK, MET, BRAF, PIK3CA, and TP53. Of these hot spot mutations, one sample expressing an EML4-ALK fusion was further confirmed by Ventana IHC, and one sample containing an EGFR exon 19 deletion was also confirmed. The NGS results imply that TP53 mutations occur often in PSCs and that EML4-ALK fusion events and EGFR exon deletions also occur in these rare tumors. Molecular targeted therapy may be a useful treatment strategy for these rare lung tumors.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance and Next-Generation Sequencing of Chinese Pulmonary Sarcomatoid Carcinoma

Wang

Ren

et al. 2017

Sci Rep

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“…In terms of treatment options for this highly aggressive tumor, surgical removal is the main corner of treatment if possible [6,18]. According to evidence-based medicine, PCS is currently managed with standard treatments used for NSCLC [15,18,19].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Carcinosarcoma: A Rare Disease With Challenging Diagnosis and Treatment

Mekheal¹,

Kapoor²,

Roman³

et al. 2022

Cureus

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Pulmonary carcinosarcoma (PCS) is a rare type of non-small cell cancer. Overall, middle-aged and older smokers are the most affected age and sex groups. The diagnosis of PCS is difficult due to the absence of characteristic imaging findings. Additionally, preoperative biopsies do not usually reflect the heterologous nature of this tumor. Given the rarity of such tumors and the challenging diagnosis, the prognostic factors have not been established, and the overall prognosis remains poor. The valid therapeutic options are still limited. Here, we report a rare case of metastatic PCS that was accidentally discovered by imaging and properly diagnosed after surgical resection. The clinicopathological features, diagnostic tools, genetic theories, prognosis, and therapeutic options of this rare cancer are also discussed.

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“…The second form is peripheral, with a bad prognosis, responsible for pain following the invasion of the chest wall as reported in case 1. An incidental radiological PSC has been reported in 6.7% of cases [5].…”

Section: Discussionmentioning

confidence: 99%

Report of Two Pulmonary Sarcomatoïd Carcinoma Cases With Highlights on the Computed Tomography Features

Aichouni

Kora

Thouil

et al. 2021

Cureus

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Pulmonary sarcomatoïd carcinomas are a heterogeneous group of poorly differentiated non-small cell tumors with a sarcomatous component. On imaging, they appear as peripheral or central masses, sometimes excavated. We report two cases of pulmonary sarcomatoïd lung carcinoma. The first case involves a 73-year-old active smoker who presented with dyspnea. A computed tomography (CT) scan showed a large locally advanced left lower lobar tumor process. A CT-guided biopsy was performed and the histopathological examination concluded a pulmonary sarcomatoïd carcinoma. The second case involves a 52-year-old chronic smoker who presented with hemoptysis. CT pulmonary angiography showed an excavated right upper lobar tumor. Histologic work-up of the right upper lobectomy piece objectified a pulmonary sarcomatoïd carcinoma. Pulmonary sarcomatoïd carcinoma has a nonspecific appearance on imaging and should be a part of imaging differential diagnoses in front of a large, lobulated, highly invasive lung tumor with or without excavation.

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Carcinomes sarcomatoïdes du poumon : étude rétrospective de 28 cas

Cited by 14 publications

References 18 publications

Clinical Significance and Next-Generation Sequencing of Chinese Pulmonary Sarcomatoid Carcinoma

Clinical Significance and Next-Generation Sequencing of Chinese Pulmonary Sarcomatoid Carcinoma

Pulmonary Carcinosarcoma: A Rare Disease With Challenging Diagnosis and Treatment

Report of Two Pulmonary Sarcomatoïd Carcinoma Cases With Highlights on the Computed Tomography Features

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