Carcinome hépatocellulaire non fibrolamellaire sur foie sain

Bouomrani, Salem; Kilani, I.; Nouma, Hanène; Slama, Alaeddine; Béji, M.

doi:10.11604/pamj.2014.18.155.2762

Cited by 1 publication

(2 citation statements)

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“…The development of HCC on previously healthy liver is exceptional [5] . This eventuality represented only 0.32% in the largest series of Giannini EG et al of 3,027 cases of HCC [14] .…”

Section: Discussionmentioning

confidence: 99%

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Hepatocellular carcinoma associated to Behçet's disease

Bouomrani¹,

Rim²,

DhiaEddine³

et al. 2019

Curr Cancer Rep

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The occurrence of hepatocellular carcinoma (HCC) on a healthy liver is exceptional and represents a real diagnosis challenge for the clinician. Recently a particularly increased risk of cancer during Behçet's disease (BD) was reported by several studies. Only a few sporadic cases of liver cancer associated with this vascultis have been reported. We report an original observation of non-fibrolamellar HCC occurring on healthy liver in a Tunisian patient followed for BD. A 43-year-old man, followed since the age of 25 for BD with isolated cutaneous and mucosal involvement, and treated by colchicine, was admitted for exploration of a pain of the right hypochondrium evolving since a few months associated with an important slimming, anorexia, and evening fever. The clinical examination noted a firm and painful hepatomegaly. Radiological exploration (ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI)) showed a bulky hepatic tumor with highly developed arterial blood supply. Ultrasound-guided biopsy concluded at HCC without signs of fibrolamellar type or cirrhosis. Biological tests were without abnormalities and specific investigations eliminated underlying chronic hepatopathy (chronic viral hepatitis B or C, hemochromatosis, Wilson's disease or autoimmune hepatitis). The patient was treated symptomatically given the advanced stage of cancer. He quickly died after a month because of a multi-organ failure. HCC on healthy liver is exceptional and BD was suggested as a possible contributing factor. Thus, regular radiological monitoring seems to be recommended in any patient followed for BD, especially those with hepatic veins thrombosis.

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“…The development of HCC on previously healthy liver is exceptional [5] . This eventuality represented only 0.32% in the largest series of Giannini EG et al of 3,027 cases of HCC [14] .…”

Section: Discussionmentioning

confidence: 99%

“…Rare cases can develop on previously healthy liver; specifically fibrolamellar carcinoma [3] . Apart from this particular histological type, chronic hepatitis C (CHC) on healthy liver remains exceptional [4,5] .…”

Section: Introductionmentioning

confidence: 99%