Carcinome canalaire in situ du sein

Cutuli, B.; Fay, Renaud; Nir, C. Cohen-Solal-Le; Lafontan, B. De; Mignotte, H.; Servent, V.; Giard, S.; Auvray, H.; Charra-Brunaud, C.; Gonzague-Casabianca, L.; Quétin, Philippe

doi:10.1016/s0755-4982(04)98490-4

Cited by 15 publications

(1 citation statement)

References 36 publications

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“…In a review of 21 studies involving DCIS patients who were treated by mastectomy, a 0.4% incidence of recurrence was observed (Lagios et al, 1989;Boyages et al, 1999;Silverstein et al, 1999;Mirza et al, 2000). Significantly lower local recurrence rates after a total mastectomy compared to corresponding rates after BCS were confirmed by Cutuli et al (2001), who reported local recurrence rates of 2.1%, 30.1%, and 13.8% in the mastectomy, BCS alone, and BCS with RT patient groups, respectively, after a 91 month follow-up period (Cutuli et al, 2001). Randomized trials also confirmed this trend and revealed the benefit of RT and hormonal treatment after BCS to reduce the rate of IBCR (Fisher et al, 1998;Houghton et al, 2003).…”

Section: Discussionmentioning

confidence: 96%

Factors Predicting Microinvasion in Ductal Carcinoma in situ

Ozkan-Gurdal¹,

Cabıoğlu²,

Özçınar³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Whether sentinel lymph node biopsy (SLNB) should be performed in patients with pure ductal carcinoma in situ (DCIS) of the breast has been a question of debate over the last decade. The aim of this study was to identify factors associated with microinvasive disease and determine the criteria for performing SLNB in patients with DCIS. Materials and Methods: 125 patients with DCIS who underwent surgery between January 2000 and December 2008 were reviewed to identify factors associated with DCIS and DCIS with microinvasion (DCISM). Results: 88 patients (70.4%) had pure DCIS and 37 (29.6%) had DCISM. Among 33 DCIS patients who underwent SLNB, one patient (3.3%) was found to have isolated tumor cells in her biopsy, whereas 1 of 14 (37.8%) patients with DCISM had micrometastasis (7.1%). Similarly, of 16 patients (18.2%) with pure DCIS and axillary lymph node dissection (ALND) without SLNB, none had lymph node metastasis. Furthermore, of 20 patients with DCISM and ALND, only one (5%) had metastasis. In multivariate analysis, the presence of comedo necrosis [relative risk (RR)=4.1, 95% confidence interval (CI)=1.6-10.6, P=0.004], and hormone receptor (ER or PR) negativity (RR=4.0, 95%CI=1.5-11, P=0.007), were found to be significantly associated with microinvasion. Conclusions: Our findings suggest patients presenting with a preoperative diagnosis of DCIS associated with comedo necrosis or hormone receptor negativity are more likely to have a microinvasive component in definitive pathology following surgery, and should be considered for SLNB procedure along with patients who will undergo mastectomy due to DCIS.

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