Carcinomas of the lacrimal drainage system

Ramberg, Ingvild; Toft, Peter Bjerre; Heegaard, Steffen

doi:10.1016/j.survophthal.2020.04.001

Cited by 24 publications

(54 citation statements)

References 135 publications

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“…Another remarkable determinant for early diagnosis is the time from first symptoms to medical contact: consistent with the reported time from first symptoms to diagnosis of LDS squamous cell carcinoma by Ramberg et al, 1 this feature can be extremely heterogeneous and reach up to 4 years in the LSDM sample. Such evidence confirms the hidden nature of LDSM, whose common symptoms raise a low level of alert in society and among general practitioners.…”

Section: Discussionsupporting

confidence: 79%

“…However, considering the low inspection accessibility of the lacrimal pathway, LDSM suffer a more consistent diagnostic delay 38 . In this regard, as the LDS is obscured from inspection, the suspicion of LDSM must derive from appraisal of signs and symptoms, which are common to the majority of LDS malignancies 1 . The most frequent in the present review were unilateral epiphora, a mass or swelling in the medial canthus region, bloody tears, and epistaxis.…”

Section: Discussionmentioning

confidence: 79%

“…The most frequent in the present review were unilateral epiphora, a mass or swelling in the medial canthus region, bloody tears, and epistaxis. Nevertheless, even if some of these clinical findings are more suggestive for malignancy, others, like epiphora, are common in many benign diseases and are often not routinely investigated through imaging 1,42 . In particular, to identify an obstruction of the LDS as the cause of epiphora, ambulatory assessment (Jones test I and II) is usually sufficient, and a 2008 survey by Nagi et al reported that less than 5% of ophtalmoplastic and reconstructive surgeons use imaging for epiphora believed to be due to lacrimal obstruction 43‐45 .…”

Section: Discussionmentioning

confidence: 99%

“…The lacrimal drainage system (LDS) is responsible for the flow of tears from the medial canthus to the inferior meatus of the nasal cavity. Its epithelium ranges from the stratified squamous form, which covers the canaliculi, to the stratified columnar one that is primarily present in the lacrimal sac and nasolacrimal duct 1 . In addition to epithelial cells, melanocytes, mesenchymal cells, goblet cells, and lymphoid cells are also physiologically present in the LDS, with the result that tumors arising in this system have many phenotypes 1 .…”

Section: Introductionmentioning

confidence: 99%

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Melanoma of the lacrimal drainage system: A systematic review

et al. 2021

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Melanoma of the lacrimal drainage system (LDSM) is a rare and subtle condition that is frequently misdiagnosed. In the present work, we conducted a systematic review investigating the clinical features, management, and prognosis of LDSM. A structured search, according to PRISMA criteria, was performed in April 2020 and updated in February 2021 on Pubmed, EMBASE, Cochrane, and SCOPUS. The articles found underwent a double‐reviewer selection and the main data were extracted. After complete screening, 30 articles reporting 38 cases were included. The time from the first symptom to medical contact ranged from 1 month to 4 years. Surgery was the treatment proposed to all patients, with a variable extension of resection. LDSM is a rare disease that is burdened by poor prognosis. Early diagnosis is crucial, even if difficult to achieve. Surgery and radiotherapy are standardized treatments, while targeted therapy and immunotherapy are attractive prospects.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Melanoma of the lacrimal drainage system: A systematic review

et al. 2021

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“…Distal acquired lacrimal obstruction (DALO) is a common pathology that affects the lacrimal drainage system distal to Rosenmuller's valve and its main clinical presentation is represented by epiphora or recurrent dacryocystitis [1]. The main etiology for this entity is believed to be idiopathic, also known as primary acquired nasolacrimal duct obstruction (PANDO), even if other causes have been described [2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Long-term results of a balloon-assisted endoscopic approach in failed dacryocystorhinostomies

Vinciguerra

Indelicato

Resti

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose Endoscopic endonasal balloon-assisted dacryoplasty is a minimally invasive surgical approach that can be applied after failure of dacryocystorhinostomy with recurrence of distal acquired lacrimal obstruction. Methods At the Department of Otolaryngology, San Raffaele Hospital, Milan (Italy), from December 2016 to October 2020, 14 patients underwent trans-nasal balloon-assisted dacryoplasty after a failed dacryocystorhinostomy (both external and endoscopic endonasal). The routinary pre-operative work-up included multidisciplinary study of the lacrimal disease, which consisted in primary ophthalmological and otorhinolaryngological visits associated with nasal endoscopy, in which a radiological exam was added if needed. The surgical approach includes pneumatic enlargement of the stenotic rhinostomy, created during the primary dacryocystorhinostomy, using a high-pressure trans-nasal balloon catheter. Anatomical success was considered when the ostium was patent upon irrigation, while functional success was considered as resolution of epiphora or free lacrimal flow on functional test. Results Among 14 patients included and after a mean follow-up of 19.5 months (range 13-51 months), anatomic success was achieved in 100% of patients and functional success was achieved in the 85.7% (12/14). Operative time ranged from 9 to 28 min (mean 18 min) and no complications were reported. Conclusion Trans-nasal balloon-assisted dacryoplasty is a mini-invasive surgical approach to treat failed dacryocystorhinostomies with reliable and stable outcomes in the long term. The absence of post-surgical complications, high success rate and short operative time are the main features of this innovative procedure.

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Lacrimal sac squamous cell carcinoma: From resection to prosthetic rehabilitation. A case report

Poghosyan,

Gharakeshishyan,

Misakyan

et al. 2023

Clinical Case Reports

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Key Clinical MessageThere is a lack of consensus and evidence on treatment strategies for lacrimal sac carcinomas. Wide en bloc surgical resection with farther prosthetic rehabilitation could be the treatment option in certain cases.AbstractMalignant epithelial lacrimal sac tumors are rare cancers with high recurrence rates. Diagnosis of these tumors is often delayed as they are confused with chronic dacryocystitis. There is a lack of consensus and evidence on standard treatment strategies for advanced lacrimal sac carcinomas. A case of advanced lacrimal sac squamous cell carcinoma treated with wide en bloc margin‐negative surgical resection with further prosthetic rehabilitation without adjuvant therapy and 38 months of recurrence‐free postoperative follow‐up is presented.

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Carcinomas of the lacrimal drainage system

Cited by 24 publications

References 135 publications

Melanoma of the lacrimal drainage system: A systematic review

Melanoma of the lacrimal drainage system: A systematic review

Long-term results of a balloon-assisted endoscopic approach in failed dacryocystorhinostomies

Lacrimal sac squamous cell carcinoma: From resection to prosthetic rehabilitation. A case report

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