Carcinomas arising in multilocular thymic cysts of the neck: a clinicopathological study of three cases

Moran, César A.; Suster, Saul; El‐Naggar, Adel K.; Luna, Mario A.

doi:10.1111/j.1365-2559.2004.01767.x

Cited by 33 publications

(12 citation statements)

References 28 publications

(65 reference statements)

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“…Likewise, MTCs have been described in patients with Sjögren’s disease 123,127 . Malignant epithelial tumours, both typical thymomas as well as carcinomas of various subtypes, have been reported to occur within MTCs 123,128–130 . However, in the series of 18 MTCs reported by Suster and Rosai, four cysts were found to harbour a thymoma or carcinoma, suggesting that rather than true incidental findings, the tumours were probably causative to the formation of the cyst in the first place.…”

Section: General Remarksmentioning

confidence: 99%

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Bakker

Oosterhuis

2009

Histopathology

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Masses within the thymus and mediastinum are frequently biopsied to establish a diagnosis. The specimens sent for histopathological analysis are typically small (needle) biopsy specimens on which the pathologist is challenged to provide a classifying diagnosis. Despite the fact that the pathology of the anterior mediastinum is predominantly centred on the thymus and it thus might be expected that the range of possible diagnoses is limited, the list of disease entities is in fact extensive, encompassing hyperplastic conditions and both benign and malignant neoplasms. In addition to primary thymic epithelial tumours, a number of less common diseases typical for this location may be encountered, including extragonadal germ cell tumours, lymphomas, soft tissue tumours and a number of conditions which may simulate a tumour, such as cysts and inflammatory conditions. In this review, the disease entities that may be encountered in biopsy material from anterior mediastinal/thymic processes are discussed and an approach to tackle the differential diagnosis is provided.

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Section: General Remarksmentioning

confidence: 99%

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Bakker

Oosterhuis

2009

Histopathology

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“…We found only three documented cases in our hospital files over a period of 15 yr. Only eleven other BTCs have been previously reported in the surgical pathology literature as part of a series or as case reports (Table II). [3][4][5][6][7][8][9] The mean age of presentation is 62 yr, including our current cases. 7 The male-to-female ratio is 8:5.…”

Section: Discussionmentioning

confidence: 99%

Fine‐needle aspiration cytology of thymic basaloid carcinoma: Case studies and review of the literature

Posligua¹,

Ylagan²

2006

Diagnostic Cytopathology

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We report the features in fine-needle aspiration biopsy (FNAB) of thymic basaloid carcinomas. This is a rare neoplasm, of which there are only three documented in our hospital files. To the best of our knowledge, this is the first fine-needle aspiration (FNA) report on basaloid carcinoma of the thymus. This is a tumor in which the FNA diagnosis is difficult and the differential diagnosis is broad. We describe the cytologic features encountered in the three cases, and immunohistochemical and ultrastructural findings so as to raise awareness of this entity in the differential diagnosis of thymic neoplasms on FNABs. The cases studied included three male patients, aged 73, 65, and 50, who presented with anterior mediastinal masses, with no primary tumor elsewhere. FNAB was performed on two cases, followed by thymectomy. One case, additionally, had metastasis to a cervical lymph node, and the other two were associated with thymic cysts. The diagnoses on all three cases were thymic basaloid carcinoma.

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“…MTC is believed to be the result of hyperplastic and cystic changes of thymic epithelium in response to an underlying inflammatory process of known or unknown cause [1,3]. Thus, MTC has been documented in adult and pediatric patients with mediastinal tumors such as teratoma, lymphoma and thymic carcinoma [4,5] and exceptionally in association with Langerhans' cell histiocytosis of the thymus [2]. Additionally, MTC can be encountered in close association with underlying inflammation of thymic parenchyma and was thus described in patients with various autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, Hashimoto thyroiditis, and Sjögren's syndrome [1,3].…”

Section: Discussionmentioning

confidence: 99%

Acute respiratory failure revealing a multilocular thymic cyst in an infant: a case report

et al. 2009

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IntroductionMultilocular thymic cysts are rare benign lesions of the neck and mediastinum that can occur at any age. In children, multilocular thymic cysts are usually symptomatic after the age of 2 years and produce few symptoms. We present an unusual case of a multilocular thymic cyst diagnosed in a 3-month-old girl and causing severe respiratory failure.Case presentationA 3 month-old-girl, with a medical history of dyspnea and wheezing since the age of 20 days, presented in our pediatric intensive care unit for acute respiratory failure requiring mechanical ventilation. The chest radiograph showed thoracic distension without any other abnormalities. The diagnosis of severe asthma was initially suspected and the patient was treated by intravenous corticosteroids and continuous perfusion of salbutamol without any improvement. A chest tomography scan was performed and demonstrated an anterior mediastinal multiseptated cystic mass extending from the inferior face of the thyroid gland to the left cardiophrenic angle. Sternotomy and excision biopsy were planned urgently. The cystic mass was excised completely. The histopathological examination confirmed the diagnosis of a multilocular thymic cyst.ConclusionThe particularities of our observation are the occurrence of a multilocular thymic cyst in a young infant and its presentation by a severe acute respiratory failure mimicking asthma.

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Carcinomas arising in multilocular thymic cysts of the neck: a clinicopathological study of three cases

Abstract: The cases described here represent an unusual variant of carcinoma arising in multilocular thymic cyst in the neck region.

Cited by 33 publications

References 28 publications

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Tumours and tumour‐like conditions of the thymus other than thymoma; a practical approach

Fine‐needle aspiration cytology of thymic basaloid carcinoma: Case studies and review of the literature

Acute respiratory failure revealing a multilocular thymic cyst in an infant: a case report

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