1999
DOI: 10.1002/(sici)1097-0215(19991210)83:6<815::aid-ijc21>3.0.co;2-z
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CarcinomaIn situ of the testis: Review of biological and clinical features

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Cited by 224 publications
(32 citation statements)
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“…First, the distinct and highly reproducible expression patterns of p19 INK4d in testicular tissues and tumours are consistent with the theory of origin of the human male germ-cell tumours from the primordial germ cells (Grigor and Wylie, 1998;Dieckmann and Skakkebñk, 1999;Skakkebñk et al, 1987). Second, our data shed new light on the puzzling issue of redundancy within the INK4 family of Cdk inhibitors (Ruas and Peters, 1998;Sherr and Roberts, 1999), in particular the question why p19 INK4d which shares its biochemical properties with the closely related p16 INK4a tumour suppressor, is apparently not targeted by mutations in cancer.…”
Section: Resultssupporting
confidence: 78%
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“…First, the distinct and highly reproducible expression patterns of p19 INK4d in testicular tissues and tumours are consistent with the theory of origin of the human male germ-cell tumours from the primordial germ cells (Grigor and Wylie, 1998;Dieckmann and Skakkebñk, 1999;Skakkebñk et al, 1987). Second, our data shed new light on the puzzling issue of redundancy within the INK4 family of Cdk inhibitors (Ruas and Peters, 1998;Sherr and Roberts, 1999), in particular the question why p19 INK4d which shares its biochemical properties with the closely related p16 INK4a tumour suppressor, is apparently not targeted by mutations in cancer.…”
Section: Resultssupporting
confidence: 78%
“…This concept has prompted a new classi®cation of germ-cell tumours which is based on biological understanding of the histogenesis, and which proposes a term`gonocytoma' for seminomatous tumours and`gonocytoma in situ' for CIS (Grigor, 1993;Grigor and Wyllie, 1998). A major argument in favour of the above hypothesis comes from comparative analyses of foetal germ cells which share a number of morphological and biochemical features with CIS cells (Jùrgensen et al, 1995;Rajpert-De Meyts et al, 1998;Dieckmann and Skakkebñk, 1999). Given the evidence for high abundance of the p19 INK4d protein during human spermatogenesis (this study), and the structural and biochemical similarities of p19 INK4d with the p16 INK4a tumour suppressor (Ruas and Peters, 1998;Roussel, 1999), we wished to explore the potential role, if any, of p19 INK4d in human testicular germ-cell pathogenesis.…”
Section: Resultsmentioning
confidence: 99%
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“…1,29 Smiraglia et al 14 have proposed a model whereby seminomas arise from IGCNU cells derived from primordial germ cells that have developed to the point whereby they have undergone 5 m C erasure. However, for nonseminomatous germ cell tumors, these authors proposed that they arise from IGCNU cells derived from primordial germ cells that had progressed past this point in their maturation in which they have undergone reprogramming by de novo methylation to contain normal 5 m C levels.…”
mentioning
confidence: 99%
“…Higher incidence of TGCTs in certain ethnic groups and in men with a family history of TGCTs [1-3] indicates a strong genetic predisposition to this cancer. Some of the genes, genetic loci and signaling pathways that contribute to TGCTs have been identified [4-9].…”
Section: Introductionmentioning
confidence: 99%