Carcinoma with eccrine differentiation arising in a seborrhoeic keratosis

Miracco, Clelia; Angeloni, Giulia; Miracco, F.; Pirtoli, Luigi

doi:10.1046/j.1365-2133.2003.05255.x

Cited by 2 publications

(4 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this case, a small nodular lesion composed of BD and eccrine porocarcinoma appeared within a pre‐existing elevated macular SK lesion. Several types of malignant neoplasms arising in SK have been reported in the literature 3,5–9 . Most of these malignant tumours are basal cell carcinomas.…”

Section: Reportmentioning

confidence: 99%

See 1 more Smart Citation

Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis

et al. 2006

View full text Add to dashboard Cite

An association between seborrhoeic keratosis (SK) and malignant tumours is considered to be rare. We observed a case of eccrine porocarcinoma and Bowen's disease (BD) occurring synchronously, forming one lesion in a SK on the abdomen. It is controversial whether malignant neoplasms arising in SK occur only by chance or if pre-existing SK plays a role in pathogenesis. This case suggests an implication of pre-existing SK in the subsequent development of both BD and eccrine porocarcinoma.

show abstract

Section: Reportmentioning

confidence: 99%

“…Most of these malignant tumours are basal cell carcinomas. Some cases of BD and malignant sweat‐gland tumours have been reported 5–9 . It is controversial whether malignant neoplasms arising in SK occur only by chance or if pre‐existing SK plays a particular role in the pathogenesis of the malignant neoplasms.…”

Section: Reportmentioning

confidence: 99%

Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis

et al. 2006

View full text Add to dashboard Cite

show abstract

“…[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] In addition, porocarcinoma has rarely been reported as a combined tumor with seborrheic keratosis. [30][31][32][33][34] However, 2 of these studies did not contain histopathological images. 30,31 In addition, the other studies may include squamous cell carcinoma involving normal eccrine ducts 32 and basaloid squamous cell carcinoma with no sweat ductal differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…[30][31][32][33][34] However, 2 of these studies did not contain histopathological images. 30,31 In addition, the other studies may include squamous cell carcinoma involving normal eccrine ducts 32 and basaloid squamous cell carcinoma with no sweat ductal differentiation. 33,34 Thus, they may actually be squamous cell carcinomas resembling porocarcinoma, just like in our cases.…”

Section: Discussionmentioning

confidence: 99%

Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases

Goto

Ogawa

Hishima

et al. 2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Seborrheic keratosis is a common benign neoplasm composed of basaloid keratinocytes. However, little is known about the malignant transformation of the tumor. Eleven cases of seborrheic keratosis with malignant transformation were analyzed. The 11 patients included 5 male patients and 6 female patients with a median age of 75 years at diagnosis (68-90 years). The tumors arose at various sites from the scalp (n = 3) to the lower leg (n = 2). The median tumor size was 12 (10-32) and 40 (20-75) mm in 7 noninvasive and 4 invasive cases, respectively. One patient exhibited intransit skin metastasis. Histopathology of the malignant components resembled porocarcinoma or inverted follicular keratosis. Bowenoid and pagetoid spreading was frequently observed. The malignant components expressed cytokeratin 5/6 (100%) and GATA3 (73%), but not cytokeratin 7 (0%), cytokeratin 19 (9%), BerEP4 (0%), c-kit (0%), and NUT (0%). No significant immunoreactivity of YAP1 was observed in any of the cases. Mutant-type immunostaining of p53 and PTEN was observed in 91% and 82% of the cases, respectively. An increase in p16 expression was seen in 6 (86%) of the 7 cases with noninvasive carcinoma, although a loss of p16 immunoexpression was seen in the invasive carcinoma component in 3 (75%) of the 4 cases. This study demonstrated that seborrheic keratosis can undergo malignant transformation, particularly in large-sized lesions in elderly patients. Malignant components mimic porocarcinoma or inverted follicular keratosis. Malignant transformation induced by TP53 and PTEN mutations and tumor invasion by CDKN2A inactivating mutations are suggested in this study.

show abstract

Carcinoma with eccrine differentiation arising in a seborrhoeic keratosis

Cited by 2 publications

References 8 publications

Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis

Eccrine porocarcinoma and Bowen's disease arising in a seborrhoeic keratosis

Seborrheic Keratosis With Malignant Transformation (Invasive or Noninvasive Squamous Cell Carcinoma Arising in Seborrheic Keratosis): A Clinicopathologic and Immunohistochemical Study of 11 Cases

Contact Info

Product

Resources

About